Distance-dependent inhibition in the hippocampus (Strüber et al. 2017)

Network model of a hippocampal circuit including interneurons and principal cells. Amplitude and decay time course of inhibitory synapses can be systematically changed for different distances between connected cells. Various forms of excitatory drives can be administered to the network including spatially structured input.

Model Type: Realistic Network

Region(s) or Organism(s): Dentate gyrus

Cell Type(s): Dentate gyrus granule GLU cell; Dentate gyrus basket cell

Receptors: GabaA; Glutamate

Transmitters: Gaba; Glutamate

Model Concept(s): Gamma oscillations; Spatio-temporal Activity Patterns

Simulation Environment: NEURON

Implementer(s): Strüber, Michael [michael_strueber at hotmail.com]

References:

Strüber M, Sauer JF, Jonas P, Bartos M. (2017). Distance-dependent inhibition facilitates focality of gamma oscillations in the dentate gyrus. Nature communications. 8 [PubMed]