A detailed biophysical model for a neuron/astrocyte network is developed in order to explore mechanisms responsible for cortical spreading depolarizations. This includes a model for the Na+-glutamate transporter, which allows for a detailed description of reverse glutamate uptake. In particular, we consider the specific roles of elevated extracellular glutamate and K+ in the initiation, propagation and recurrence of spreading depolarizations.
Model Type: Extracellular; Glia; Neuron or other electrically excitable cell
Cell Type(s): Astrocyte
Currents: I K; I Na,p; I Cl, leak; Na/K pump; Na+-glutamate transporter
Receptors: Glutamate
Transmitters: Glutamate
Model Concept(s): Detailed Neuronal Models; Potassium buffering; Spreading depression; Spreading depolarization
Simulation Environment: XPPAUT
Implementer(s): Terman, David [terman at math.ohio-state.edu]
References:
Conte C, Lee R, Sarkar M, Terman D. (2018). A mathematical model of recurrent spreading depolarizations. Journal of computational neuroscience. 44 [PubMed]