Our model simulates synchronized rhythms in the clock gene expression found in the choroid plexus. These synchronized oscillations, primarily mediated by gap junctions, showed interesting relationships between their amplitude, oscillation frequency, and coupling strength (gap junction density) in our experimental data. The model is based on coupled Poincaré oscillators and replicates this phenomenon via a non-zero "twist" in each cell.
Model Type: Neuron or other electrically excitable cell
Model Concept(s): Oscillations; Synchronization; Circadian Rhythms; Temporal Pattern Generation; Activity Patterns
Simulation Environment: MATLAB; Python; Mathematica
Implementer(s): Hong, Sungho [shhong at oist.jp]; Schmal, Christoph ; Myung, Jihwan
References:
Myung J et al. (2018). The choroid plexus is an important circadian clock component. Nature communications. 9 [PubMed]