Sensory-evoked responses of L5 pyramidal tract neurons (Egger et al 2020)


This is the L5 pyramidal tract neuron (L5PT) model from Egger, Narayanan et al., Neuron 2020. It allows investigating how synaptic inputs evoked by different sensory stimuli are integrated by the complex intrinsic properties of L5PTs. The model is constrained by anatomical measurements of the subcellular synaptic input patterns to L5PT neurons, in vivo measurements of sensory-evoked responses of different populations of neurons providing these synaptic inputs, and in vitro measurements constraining the biophysical properties of the soma, dendrites and axon (note: the biophysical model is based on the work by Hay et al., Plos Comp Biol 2011). The model files provided here allow performing simulations and analyses presented in Figures 3, 4 and 5.

Model Type: Dendrite; Realistic Network; Neuron or other electrically excitable cell

Region(s) or Organism(s): Neocortex

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Calcium; I h; I M; I K; I Na,t; I Na,p; I K,Ca

Receptors: AMPA; GabaA; NMDA

Transmitters: Glutamate; Gaba

Model Concept(s): Active Dendrites; Detailed Neuronal Models; Sensory processing; Stimulus selectivity; Synaptic Integration

Simulation Environment: NEURON; Python

Implementer(s): Egger, Robert [robert.egger at nyumc.org]

References:

Egger R, Narayanan RT, Guest JM, Bast A, Udvary D, Messore LF, Das S, de Kock CP, Oberlaender M. (2020). Cortical Output Is Gated by Horizontally Projecting Neurons in the Deep Layers Neuron 105