"Gene regulatory networks (GRNs) describe interactions between gene products and transcription factors that control gene expression. In combination with reaction–diffusion models, GRNs have enhanced comprehension of biological pattern formation. However, although it is well known that biological systems exploit an interplay of genetic and physical mechanisms, instructive factors such as transmembrane potential (Vmem) have not been integrated into full GRN models. Here we extend regulatory networks to include bioelectric signalling, developing a novel synthesis: the bioelectricity-integrated gene and reaction (BIGR) network. ..."
Model Type: Neuron or other electrically excitable cell
Model Concept(s): Reaction-diffusion; Homeostasis; Signaling pathways; Electrical-chemical
Simulation Environment: BETSE (web link to model)
Implementer(s): Pietak, Alexis
References:
Pietak A, Levin M. (2017). Bioelectric gene and reaction networks: computational modelling of genetic, biochemical and bioelectrical dynamics in pattern regulation. Journal of the Royal Society, Interface. 14 [PubMed]