We use a computational model of a striatal spiny projection neuron to investigate dendritic spine calcium dynamics in response to spatiotemporal patterns of synaptic inputs. We show that spine calcium elevation is stimulus-specific, with supralinear calcium elevation in cooperatively stimulated spines. Intermediate calcium elevation occurs in neighboring non-stimulated dendritic spines, predicting heterosynaptic effects. Inhibitory synaptic inputs enhance the difference between peak calcium in stimulated spines, and peak calcium in non-stimulated spines, thereby enhancing stimulus specificity.
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Basal ganglia
Cell Type(s): Neostriatum spiny neuron
Simulation Environment: GENESIS
Implementer(s): Dorman, Daniel B
Dorman DB, Jedrzejewska-Szmek J, Blackwell KT. (2018). Inhibition enhances spatially-specific calcium encoding of synaptic input patterns in a biologically constrained model. Elife 7 [PubMed]