Using a biophysically realistic model of CA1 pyramidal cells together with a combination of single-cell and multisite electrophysiological recordings, we have studied factors underlying the internal theta phase preference of identified cell types from the dorsal CA1. We found that perisomatic inhibition delivered by complementary populations of basket cells interacts with input pathways to shape phase-locked specificity of deep and superficial CA1 pyramidal cells. Somatodendritic integration of fluctuating glutamatergic inputs defined cycle-by-cycle by nested waveforms demonstrated that firing selection is tuneable across sublayers under the relevant influence of intrinsic factors. Our data identify a set of testable physiological mechanisms underlying a phase specific firing reservoir that can be repurposed for high-level flexible dynamical representations. Documentation in https://acnavasolive.github.io/LCN-HippoModel/. More info: http://hippo-circuitlab.es/
Model Type: Neuron or other electrically excitable cell
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA1 pyramidal GLU cell
Currents: I A; I h; I M; I Sodium; I Potassium; I Calcium; I_AHP; I T low threshold; I L high threshold; I K; I C
Model Concept(s): Spatio-temporal Activity Patterns
Simulation Environment: NEURON; Python
Implementer(s): Navas-Olive, Andrea [acnavasolive at gmail.com]
References:
Navas-Olive A et al. (2020). Multimodal determinants of phase-locked dynamics across deep-superficial hippocampal sublayers during theta oscillations. Nature communications. 11 [PubMed]