The paper describes an experimental model of the alpha rhythm generated by layer 4 pyramidal neurons in a visual cortex slice. The simulation model is derived from that of Traub et al. (2005) J Neurophysiol, developed for thalamocortical oscillations.
Model Type: Realistic Network
Region(s) or Organism(s): Thalamus; Neocortex
Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex U1 L6 pyramidal corticalthalamic GLU cell; Neocortex U1 L2/6 pyramidal intratelencephalic GLU cell; Neocortex layer 4 pyramidal cell; Neocortex fast spiking (FS) interneuron; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron; Neocortex spiny stellate cell
Currents: I Na,p; I Na,t; I L high threshold; I A; I K; I M; I h; I K,Ca; I Calcium; I A, slow
Model Concept(s): Brain Rhythms; Dendritic Action Potentials
Simulation Environment: FORTRAN
Implementer(s): Traub, Roger D [rtraub at us.ibm.com]
References:
Traub RD, Hawkins K, Adams NE, Hall SP, Simon A, Whittington MA. (2020). Layer 4 pyramidal neuron dendritic bursting underlies a post-stimulus visual cortical alpha rhythm Nature Communications Biology, in press