Two forms of synaptic depression by neuromodulation of presynaptic Ca2+ channels (Burke et al 2018)


"... To determine whether the different biophysical mechanisms of CaV modulation predicted by OFA (Optical Fluctuation Analysis) are sufficient to explain the differing effects of D1Rs and GABA B Rs on STP, we developed a reduced synaptic model..."

Model Type: Synapse; Neuron or other electrically excitable cell

Region(s) or Organism(s): Prefrontal cortex (PFC)

Currents: I Calcium

Receptors: Dopaminergic Receptor

Model Concept(s): Facilitation; Short-term Synaptic Plasticity; Synaptic Plasticity; Calcium dynamics

Simulation Environment: Python (web link to model)

References:

Bender KJ, Keeshen CM, Burke KJ. (2018). Two Forms of Synaptic Depression Produced by Differential Neuromodulation of Presynaptic Calcium Channels. Neuron 99 [PubMed]