Library of compartmentalized models used to investigate dendritic integration in striatal projection neurons under neuromodulation.
Model Type: Neuron or other electrically excitable cell; Synapse
Region(s) or Organism(s): Striatum; Hippocampus; Basal ganglia
Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell; Striatal projection neuron
Currents: I M; I Potassium
Transmitters: Acetylcholine; Dopamine
Model Concept(s): Active Dendrites; Detailed Neuronal Models; Neuromodulation; Synaptic Plasticity; Activity Patterns; Soma-dendrite cross-talk
Simulation Environment: NEURON; Python
Implementer(s): Lindroos, Robert [robert.lindroos at ki.se]; Filipovic, Marko
References:
Lindroos R, Hellgren Kotaleski J. (2021). Predicting complex spikes in striatal projection neurons of the direct pathway following neuromodulation by acetylcholine and dopamine. The European journal of neuroscience. 53 [PubMed]