Coincidence detection in MSO principal cells (Goldwyn et al. 2019)

How a particular combination of anatomical and biophysical properties results in a short integration window (good for detection of closely-coincident inputs) while also enabling efficient axonal firing with brief interspike intervals (needed to faithfully report a series of coincidences between high frequency presynaptic spike trains).

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Auditory brainstem

Cell Type(s): Medial Superior Olive (MSO) cell

Currents: I Sodium; I_KLT

Model Concept(s): Coincidence Detection; Synaptic Integration; Two-port analysis of electrotonus; Voltage transfer ratio; Equivalent PI circuit; Excitability

Simulation Environment: MATLAB

Implementer(s): Goldwyn, Joshua [jhgoldwyn at gmail.com]

References:

Goldwyn JH, Remme MWH, Rinzel J. (2019). Soma-axon coupling configurations that enhance neuronal coincidence detection. PLoS computational biology. 15 [PubMed]