Cardiac models of circadian rhythms in early afterdepolarizations & arrhythmias (Diekman & Wei 2021)

We fit a simplified Luo-Rudy model to voltage-clamp data showing a circadian rhythm in L-type calcium conductance. Simulations of the model (single-cell and 2-D spatial versions) suggest that circadian rhythms in early afterdepolarizations may contribute to daily rhythms in cardiac arrhythmias and sudden cardiac death.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Cardiac ventricular cell

Currents: I Calcium; I K

Model Concept(s): Circadian Rhythms; Action Potentials; Cardiac pacemaking; Bifurcation

Simulation Environment: MATLAB

Implementer(s): Diekman, Casey O. [casey.o.diekman at njit.edu]

References:

Diekman CO, Wei N. (2021). Circadian Rhythms of Early Afterdepolarizations and Ventricular Arrhythmias in a Cardiomyocyte Model. Biophysical journal. 120 [PubMed]