Cholinergic Modulation Shifts the Response of CA1 Pyramidal Cells to Depolarizing Ramps via TRPM4 Channels with Potential Implications for Place Cell Firing (Combe et al., 2023)

Model of Cholinergic modulation of a CA1 pyramidal cell through TRPM4, includes a nanodomain

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Hippocampus

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I TRPM4

Transmitters: Acetylcholine

Simulation Environment: NEURON

Implementer(s): Canavier, CC; Upchurch, Carol M

References:

Combe CL, Upchurch CM, Canavier CC, Gasparini S. (2023). Cholinergic modulation shifts the response of CA1 pyramidal cells to depolarizing ramps via TRPM4 Channels with potential implications for place field firing eLife. 12 [PubMed]