Low Threshold Calcium Currents in TC cells (Destexhe et al 1998)


In Destexhe, Neubig, Ulrich, and Huguenard (1998) experiments and models examine low threshold calcium current's (IT, or T-current) distribution in thalamocortical (TC) cells. Multicompartmental modeling supports the hypothesis that IT currents have a density at least several fold higher in the dendrites than the soma. The IT current contributes significantly to rebound bursts and is thought to have important network behavior consequences. See the paper for details. See also http://cns.iaf.cnrs-gif.fr Correspondance may be addressed to Alain Destexhe: Destexhe@iaf.cnrs-gif.fr

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell

Currents: I Na,t; I T low threshold; I K

Model Concept(s): Dendritic Action Potentials; Bursting; Ion Channel Kinetics; Parameter Fitting; Simplified Models; Influence of Dendritic Geometry; Detailed Neuronal Models; Calcium dynamics; Rebound firing

Simulation Environment: NEURON

Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]

References:

Destexhe A, Neubig M, Ulrich D, Huguenard J. (1998). Dendritic low-threshold calcium currents in thalamic relay cells. J Neurosci 18 [PubMed]