Pyramidal Neuron: Deep, Thalamic Relay and Reticular, Interneuron (Destexhe et al 1998, 2001)


This package shows single-compartment models of different classes of cortical neurons, such as the "regular-spiking", "fast-spiking" and "bursting" (LTS) neurons. The mechanisms included are the Na+ and K+ currents for generating action potentials (INa, IKd), the T-type calcium current (ICaT), and a slow voltage-dependent K+ current (IM). See http://cns.fmed.ulaval.ca/alain_demos.html

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Thalamus geniculate nucleus/lateral principal GLU cell; Thalamus reticular nucleus GABA cell; Neocortex L5/6 pyramidal GLU cell; Neocortex spiking regular (RS) neuron; Neocortex spiking low threshold (LTS) neuron

Currents: I Na,t; I T low threshold; I K; I M; I Sodium; I Calcium; I Potassium

Receptors: GabaA; GabaB; AMPA; Gaba

Model Concept(s): Activity Patterns; Bursting; Action Potentials; Calcium dynamics

Simulation Environment: NEURON

Implementer(s): Destexhe, Alain [Destexhe at iaf.cnrs-gif.fr]

References:

Destexhe A, Contreras D, Steriade M. (1998). Mechanisms underlying the synchronizing action of corticothalamic feedback through inhibition of thalamic relay cells. J Neurophysiol 79 [PubMed]

Destexhe A, Contreras D, Steriade M. (2001). LTS cells in cerebral cortex and their role in generating spike-and-wave oscillations. Neurocomputing 38

Sejnowski TJ, Destexhe A. (2001). Thalamocortical Assemblies-How Ion Channels, Single Neurons and large-Scale Networks Organize Sleep