Olfactory bulb granule cell: effects of odor deprivation (Saghatelyan et al 2005)

The model supports the experimental findings on the effects of postnatal odor deprivation, and shows that a -10mV shift in the Na activation or a reduction in the dendritic length of newborn GC could independently explain the observed increase in excitability.

Model Type: Dendrite

Cell Type(s): Olfactory bulb main mitral GLU cell; Olfactory bulb main interneuron granule MC GABA cell

Currents: I Na,t; I A; I K

Receptors: AMPA; NMDA

Transmitters: Gaba; Glutamate

Model Concept(s): Action Potential Initiation; Ion Channel Kinetics; Active Dendrites; Influence of Dendritic Geometry; Action Potentials; Olfaction

Simulation Environment: NEURON

Implementer(s): Migliore, Michele [Michele.Migliore at Yale.edu]

References:

Saghatelyan A et al. (2005). Activity-dependent adjustments of the inhibitory network in the olfactory bulb following early postnatal deprivation. Neuron. 46 [PubMed]