Breakdown of accmmodation in nerve: a possible role for INAp (Hennings et al 2005)


The present modeling study suggests that persistent, low-threshold, rapidly activating sodium currents have a key role in breakdown of accommodation, and that breakdown of accommodation can be used as a tool for studying persistent sodium current under normal and pathological conditions. See paper for more and details.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Myelinated neuron

Currents: I Na,p; I Na,t; I K

Model Concept(s): Action Potential Initiation; Action Potentials; Pathophysiology; Electrotonus

Simulation Environment: MATLAB

Implementer(s): Hennings, Kristian [krist at hst.auc.dk]

References:

Hennings K, Arendt-Nielsen L, Andersen OK. (2005). Breakdown of accommodation in nerve: a possible role for persistent sodium current. Theor Biol Med Model 2 [PubMed]