... earlier experiments were carried out with 2-dimensional sheets of cells: 2 × 3, 3 × 4, and 5 × 5 models (where the first number is the number of parallel chains and the second is the number of cells in each chain). The purpose of the present study was to enlarge the model size to 7 × 7, thus enabling the transverse velocities to be compared in models of different sizes (where all circuit parameters are identical in all models). This procedure should enable the significance of the role of edge (boundary) effects in transverse propagation to be determined. See paper for more and details.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Heart cell
Currents: I Sodium; I Calcium; I Potassium
Model Concept(s): Activity Patterns; Action Potentials
Simulation Environment: PSpice
References:
Sperelakis N, Kalloor B, Ramasamy L. (2005). Boundary effects influence velocity of transverse propagation of simulated cardiac action potentials. Theoretical biology & medical modelling. 2 [PubMed]