We use a combination of dynamical analysis and electrophysiological recordings to demonstrate that spike broadening in dendrites is primarily caused by a cumulative inactivation of dendritic Na(+) current. We further show that a reduction in dendritic Na(+) current increases excitability by decreasing the interspike interval (ISI) and promoting burst firing.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): ELL pyramidal cell
Simulation Environment: MATLAB