Febrile seizure-induced modifications to Ih (Chen et al 2001)


Modeling and experiments in the paper Chen K,Aradi I, Thom N,Eghbal-Ahmadi M, Baram TZ, and Soltesz I (2001) support the hypothesis that modified Ih currents strongly influence inhibitory inputs in CA1 cells and that the depolarizing shift in Ih activation plays a primary role in this process. Please see the paper for details. Some modeling details are available at http://www.ucihs.uci.edu/anatomy/soltesz/supp.htm Correspondance should be addressed to isoltesz@uci.edu (modeling was done by Ildiko Aradi, iaradi@uci.edu)

Model Type: Channel/Receptor

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I K; I h

Model Concept(s): Action Potential Initiation; Activity Patterns; Bursting; Ion Channel Kinetics; Action Potentials; Epilepsy; Rebound firing

Simulation Environment: NEURON

Implementer(s): Aradi, Ildiko [IAradi at uci.edu]

References:

Chen K, Aradi I, Thon N, Eghbal-Ahmadi M, Baram TZ, Soltesz I. (2001). Persistently modified h-channels after complex febrile seizures convert the seizure-induced enhancement of inhibition to hyperexcitability. Nat Med 7 [PubMed]