Differential modulation of pattern and rate in a dopamine neuron model (Canavier and Landry 2006)

"A stylized, symmetric, compartmental model of a dopamine neuron in vivo shows how rate and pattern can be modulated either concurrently or differentially. If two or more parameters in the model are varied concurrently, the baseline firing rate and the extent of bursting become decorrelated, which provides an explanation for the lack of a tight correlation in vivo and is consistent with some independence of the mechanisms that generate baseline firing rates versus bursting. ..." See paper for more and details.

Model Type: Neuron or other electrically excitable cell; Electrogenic pump

Cell Type(s): Substantia nigra pars compacta DA cell

Currents: I L high threshold; I N; I T low threshold; I A; I K; I K,Ca; I Sodium; I Calcium; Na/K pump

Receptors: AMPA; NMDA; Gaba

Model Concept(s): Activity Patterns; Bursting; Detailed Neuronal Models; Intrinsic plasticity; Calcium dynamics; Sodium pump

Simulation Environment: NEURON

Implementer(s): Kuznetsova, Anna [anna.kuznetsova at utsa.edu]


Canavier CC, Landry RS. (2006). An increase in AMPA and a decrease in SK conductance increase burst firing by different mechanisms in a model of a dopamine neuron in vivo. J Neurophysiol 96 [PubMed]