Amyloid beta (IA block) effects on a model CA1 pyramidal cell (Morse et al. 2010)


The model simulations provide evidence oblique dendrites in CA1 pyramidal neurons are susceptible to hyper-excitability by amyloid beta block of the transient K+ channel, IA. See paper for details.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Hippocampus CA1 pyramidal GLU cell

Currents: I Na,t; I L high threshold; I N; I T low threshold; I A; I K; I h; I K,Ca

Model Concept(s): Dendritic Action Potentials; Active Dendrites; Detailed Neuronal Models; Pathophysiology; Aging/Alzheimer`s

Simulation Environment: NEURON

Implementer(s): Carnevale, Ted [Ted.Carnevale at Yale.edu]; Morse, Tom [Tom.Morse at Yale.edu]

References:

Morse TM, Carnevale NT, Mutalik PG, Migliore M, Shepherd GM. (2010). Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study. Front Neural Circuits 4 [PubMed]