Olfactory bulb network model of gamma oscillations (Bathellier et al. 2006; Lagier et al. 2007)


This model implements a network of 100 mitral cells connected with asynchronous inhibitory "synapses" that is meant to reproduce the GABAergic transmission of ensembles of connected granule cells. For appropriate parameters of this special synapse the model generates gamma oscillations with properties very similar to what is observed in olfactory bulb slices (See Bathellier et al. 2006, Lagier et al. 2007). Mitral cells are modeled as single compartment neurons with a small number of different voltage gated channels. Parameters were tuned to reproduce the fast subthreshold oscillation of the membrane potential observed experimentally (see Desmaisons et al. 1999).

Model Type: Realistic Network

Region(s) or Organism(s): Olfactory bulb

Cell Type(s): Olfactory bulb main mitral GLU cell

Currents: I Na,p; I Na,t; I A; I K

Receptors: GabaA

Model Concept(s): Oscillations; Delay; Olfaction

Simulation Environment: C or C++ program

References:

Bathellier B, Lagier S, Faure P, Lledo PM. (2006). Circuit properties generating gamma oscillations in a network model of the olfactory bulb. J Neurophysiol 95 [PubMed]

Lagier S, Panzanelli P, Russo RE, Nissant A, Bathellier B, Sassoè-Pognetto M, Fritschy JM, Lledo PM. (2007). GABAergic inhibition at dendrodendritic synapses tunes gamma oscillations in the olfactory bulb. Proc Natl Acad Sci U S A 104 [PubMed]

Lledo PM, Faure P, Lagier S, Bathellier B. (2006). Corrigendum for Bathellier et al., J Neurophysiol 95 (4) 2678-2691. J Neurophysiol 95