Pyramidal Neuron Deep: Constrained by experiment (Dyhrfjeld-Johnsen et al. 2005)


"... As a practical demonstration of the use of CoCoDat we constructed a detailed computer model of an intrinsically bursting (IB) layer V pyramidal neuron from the rat barrel cortex supplementing experimental data (Schubert et al., 2001) with information extracted from the database. The pyramidal neuron morphology (Fig. 10B) was reconstructed from histological sections of a biocytin-stained IB neuron using the NeuroLucida software package..."

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I Na,p; I Na,t; I L high threshold; I T low threshold; I A; I K; I M; I h; I K,Ca

Model Concept(s): Bursting

Simulation Environment: GENESIS

Implementer(s): Dyhrfjeld-Johnsen, Jonas [jdyhrfje at uci.edu]

References:

Dyhrfjeld-johnsen J, Maier J, Schubert D, Staiger J, Luhmann HJ, Stephan KE, K├Âtter R. (2005). CoCoDat: a database system for organizing and selecting quantitative data on single neurons and neuronal microcircuitry. J Neurosci Methods 141 [PubMed]