"The properties of slowly inactivating delayed-rectifier K+ current (IKdr) were investigated in NG108-15 neuronal cells differentiated with long-term exposure to dibutyryl cyclic AMP. ... The computer model, in which state-dependent inactivation of IKdr was incorporated, was also implemented to predict the firing behavior present in NG108-15 cells. ... Our theoretical work and the experimental results led us to propose a pivotal role of slowly inactivating IKdr in delayed firing of APs in NG108-15 cells. The results also suggest that aconitine modulation of IKdr gating is an important molecular mechanism through which it can contribute to neuronal firing."
Model Type: Neuron or other electrically excitable cell; Channel/Receptor
Cell Type(s): Neuroblastoma; NG108-15 neuronal cell
Currents: I Na,t; I K; I Sodium; I Potassium
Model Concept(s): Activity Patterns; Action Potentials; Delay
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Chen, Bing-Shuo
References:
Wu SN, Chen BS, Lin MW, Liu YC. (2008). Contribution of slowly inactivating potassium current to delayed firing of action potentials in NG108-15 neuronal cells: experimental and theoretical studies. Journal of theoretical biology. 252 [PubMed]