Hippocampus CA1: Temporal sensitivity of signaling pathways underlying LTP (Kim et al. 2010)


Kim M, Huang T, Abel T, Blackwell KT. (2010). Temporal sensitivity of protein kinase a activation in late-phase long term potentiation. PLoS computational biology. 6 [PubMed]

See more from authors: Kim M · Huang T · Abel T · Blackwell KT

References and models cited by this paper

Abel T et al. (1997). Genetic demonstration of a role for PKA in the late phase of LTP and in hippocampus-based long-term memory. Cell. 88 [PubMed]

Ajay SM, Bhalla US. (2004). A role for ERKII in synaptic pattern selectivity on the time-scale of minutes. The European journal of neuroscience. 20 [PubMed]

Ajay SM, Bhalla US. (2007). A propagating ERKII switch forms zones of elevated dendritic activation correlated with plasticity. HFSP journal. 1 [PubMed]

Barco A, Alarcon JM, Kandel ER. (2002). Expression of constitutively active CREB protein facilitates the late phase of long-term potentiation by enhancing synaptic capture. Cell. 108 [PubMed]

Bauman AL, Goehring AS, Scott JD. (2004). Orchestration of synaptic plasticity through AKAP signaling complexes. Neuropharmacology. 46 [PubMed]

Bhalla US, Iyengar R. (1999). Emergent properties of networks of biological signaling pathways. Science (New York, N.Y.). 283 [PubMed]

Blitzer RD et al. (1998). Gating of CaMKII by cAMP-regulated protein phosphatase activity during LTP. Science (New York, N.Y.). 280 [PubMed]

Brown GP et al. (2000). Long-term potentiation induced by theta frequency stimulation is regulated by a protein phosphatase-1-operated gate. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Cali JJ, Zwaagstra JC, Mons N, Cooper DM, Krupinski J. (1994). Type VIII adenylyl cyclase. A Ca2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. The Journal of biological chemistry. 269 [PubMed]

Castellani GC, Quinlan EM, Bersani F, Cooper LN, Shouval HZ. (2005). A model of bidirectional synaptic plasticity: from signaling network to channel conductance. Learning & memory (Cold Spring Harbor, N.Y.). 12 [PubMed]

Chakravarthy B, Morley P, Whitfield J. (1999). Ca2+-calmodulin and protein kinase Cs: a hypothetical synthesis of their conflicting convergences on shared substrate domains. Trends in neurosciences. 22 [PubMed]

Chetkovich DM, Sweatt JD. (1993). nMDA receptor activation increases cyclic AMP in area CA1 of the hippocampus via calcium/calmodulin stimulation of adenylyl cyclase. Journal of neurochemistry. 61 [PubMed]

Connor JH et al. (2000). Cellular mechanisms regulating protein phosphatase-1. A key functional interaction between inhibitor-2 and the type 1 protein phosphatase catalytic subunit. The Journal of biological chemistry. 275 [PubMed]

Coomber CJ. (1998). Site-selective autophosphorylation of Ca2+/calmodulin-dependent protein kinase II as a synaptic encoding mechanism. Neural computation. 10 [PubMed]

Corvol JC, Studler JM, Schonn JS, Girault JA, Hervé D. (2001). Galpha(olf) is necessary for coupling D1 and A2a receptors to adenylyl cyclase in the striatum. Journal of neurochemistry. 76 [PubMed]

D'Alcantara P, Schiffmann SN, Swillens S. (2003). Bidirectional synaptic plasticity as a consequence of interdependent Ca2+-controlled phosphorylation and dephosphorylation pathways. The European journal of neuroscience. 17 [PubMed]

De Koninck P, Schulman H. (1998). Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations. Science (New York, N.Y.). 279 [PubMed]

Dupont G, Houart G, De Koninck P. (2003). Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations: a simple model. Cell calcium. 34 [PubMed]

Frey U, Huang YY, Kandel ER. (1993). Effects of cAMP simulate a late stage of LTP in hippocampal CA1 neurons. Science (New York, N.Y.). 260 [PubMed]

Frey U, Morris RG. (1997). Synaptic tagging and long-term potentiation. Nature. 385 [PubMed]

Frey U, Schroeder H, Matthies H. (1990). Dopaminergic antagonists prevent long-term maintenance of posttetanic LTP in the CA1 region of rat hippocampal slices. Brain research. 522 [PubMed]

Giovannini MG et al. (2001). Mitogen-activated protein kinase regulates early phosphorylation and delayed expression of Ca2+/calmodulin-dependent protein kinase II in long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Granado N et al. (2008). D1 but not D5 dopamine receptors are critical for LTP, spatial learning, and LTP-Induced arc and zif268 expression in the hippocampus. Cerebral cortex (New York, N.Y. : 1991). 18 [PubMed]

Harvey CD, Yasuda R, Zhong H, Svoboda K. (2008). The spread of Ras activity triggered by activation of a single dendritic spine. Science (New York, N.Y.). 321 [PubMed]

Hayer A, Bhalla US. (2005). Molecular switches at the synapse emerge from receptor and kinase traffic. PLoS computational biology. 1 [PubMed]

Herberg FW, Dostmann WR, Zorn M, Davis SJ, Taylor SS. (1994). Crosstalk between domains in the regulatory subunit of cAMP-dependent protein kinase: influence of amino terminus on cAMP binding and holoenzyme formation. Biochemistry. 33 [PubMed]

Herberg FW, Taylor SS, Dostmann WR. (1996). Active site mutations define the pathway for the cooperative activation of cAMP-dependent protein kinase. Biochemistry. 35 [PubMed]

Hofmann F, Bechtel PJ, Krebs EG. (1977). Concentrations of cyclic AMP-dependent protein kinase subunits in various tissues. The Journal of biological chemistry. 252 [PubMed]

Holmes WR. (2000). Models of calmodulin trapping and CaM kinase II activation in a dendritic spine. Journal of computational neuroscience. 8 [PubMed]

Huang CC, Liang YC, Hsu KS. (2001). Characterization of the mechanism underlying the reversal of long term potentiation by low frequency stimulation at hippocampal CA1 synapses. The Journal of biological chemistry. 276 [PubMed]

Huang HB et al. (1999). Characterization of the inhibition of protein phosphatase-1 by DARPP-32 and inhibitor-2. The Journal of biological chemistry. 274 [PubMed]

Huang KP et al. (2004). Neurogranin/RC3 enhances long-term potentiation and learning by promoting calcium-mediated signaling. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Huang Q et al. (1992). Immunohistochemical localization of the D1 dopamine receptor in rat brain reveals its axonal transport, pre- and postsynaptic localization, and prevalence in the basal ganglia, limbic system, and thalamic reticular nucleus. Proceedings of the National Academy of Sciences of the United States of America. 89 [PubMed]

Huang T, McDonough CB, Abel T. (2006). Compartmentalized PKA signaling events are required for synaptic tagging and capture during hippocampal late-phase long-term potentiation. European journal of cell biology. 85 [PubMed]

Huang YY, Kandel ER. (1995). D1/D5 receptor agonists induce a protein synthesis-dependent late potentiation in the CA1 region of the hippocampus. Proceedings of the National Academy of Sciences of the United States of America. 92 [PubMed]

Huang YY, Pittenger C, Kandel ER. (2004). A form of long-lasting, learning-related synaptic plasticity in the hippocampus induced by heterosynaptic low-frequency pairing. Proceedings of the National Academy of Sciences of the United States of America. 101 [PubMed]

Hudmon A, Schulman H. (2002). Neuronal CA2+/calmodulin-dependent protein kinase II: the role of structure and autoregulation in cellular function. Annual review of biochemistry. 71 [PubMed]

Impey S et al. (1998). Cross talk between ERK and PKA is required for Ca2+ stimulation of CREB-dependent transcription and ERK nuclear translocation. Neuron. 21 [PubMed]

Johnson DA, Akamine P, Radzio-Andzelm E, Madhusudan M, Taylor SS. (2001). Dynamics of cAMP-dependent protein kinase. Chemical reviews. 101 [PubMed]

Kase H et al. (1987). K-252 compounds, novel and potent inhibitors of protein kinase C and cyclic nucleotide-dependent protein kinases. Biochemical and biophysical research communications. 142 [PubMed]

Kelly MT, Crary JF, Sacktor TC. (2007). Regulation of protein kinase Mzeta synthesis by multiple kinases in long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Krapivinsky G, Medina I, Krapivinsky L, Gapon S, Clapham DE. (2004). SynGAP-MUPP1-CaMKII synaptic complexes regulate p38 MAP kinase activity and NMDA receptor-dependent synaptic AMPA receptor potentiation. Neuron. 43 [PubMed]

Kubota Y, Bower JM. (2001). Transient versus asymptotic dynamics of CaM kinase II: possible roles of phosphatase. Journal of computational neuroscience. 11 [PubMed]

Kubota Y, Putkey JA, Waxham MN. (2007). Neurogranin controls the spatiotemporal pattern of postsynaptic Ca2+/CaM signaling. Biophysical journal. 93 [PubMed]

Lee HK. (2006). Synaptic plasticity and phosphorylation. Pharmacology & therapeutics. 112 [PubMed]

Lee HK et al. (2003). Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory. Cell. 112 [PubMed]

Lee SJ, Escobedo-Lozoya Y, Szatmari EM, Yasuda R. (2009). Activation of CaMKII in single dendritic spines during long-term potentiation. Nature. 458 [PubMed]

Lemon N, Manahan-Vaughan D. (2006). Dopamine D1/D5 receptors gate the acquisition of novel information through hippocampal long-term potentiation and long-term depression. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Lisman J. (1989). A mechanism for the Hebb and the anti-Hebb processes underlying learning and memory. Proceedings of the National Academy of Sciences of the United States of America. 86 [PubMed]

Lisman JE, McIntyre CC. (2001). Synaptic plasticity: a molecular memory switch. Current biology : CB. 11 [PubMed]

Lisman JE, Zhabotinsky AM. (2001). A model of synaptic memory: a CaMKII/PP1 switch that potentiates transmission by organizing an AMPA receptor anchoring assembly. Neuron. 31 [PubMed]

MacKenzie SJ et al. (2002). Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1). British journal of pharmacology. 136 [PubMed]

Malenka RC, Bear MF. (2004). LTP and LTD: an embarrassment of riches. Neuron. 44 [PubMed]

Martin SJ, Grimwood PD, Morris RG. (2000). Synaptic plasticity and memory: an evaluation of the hypothesis. Annual review of neuroscience. 23 [PubMed]

Masterson LR, Mascioni A, Traaseth NJ, Taylor SS, Veglia G. (2008). Allosteric cooperativity in protein kinase A. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]

Mullasseril P, Dosemeci A, Lisman JE, Griffith LC. (2007). A structural mechanism for maintaining the 'on-state' of the CaMKII memory switch in the post-synaptic density. Journal of neurochemistry. 103 [PubMed]

Navakkode S, Sajikumar S, Frey JU. (2007). Synergistic requirements for the induction of dopaminergic D1/D5-receptor-mediated LTP in hippocampal slices of rat CA1 in vitro. Neuropharmacology. 52 [PubMed]

Nguyen PV, Abel T, Kandel ER. (1994). Requirement of a critical period of transcription for induction of a late phase of LTP. Science (New York, N.Y.). 265 [PubMed]

Nguyen PV, Kandel ER. (1997). Brief theta-burst stimulation induces a transcription-dependent late phase of LTP requiring cAMP in area CA1 of the mouse hippocampus. Learning & memory (Cold Spring Harbor, N.Y.). 4 [PubMed]

Nguyen PV, Woo NH. (2003). Regulation of hippocampal synaptic plasticity by cyclic AMP-dependent protein kinases. Progress in neurobiology. 71 [PubMed]

Nie T, McDonough CB, Huang T, Nguyen PV, Abel T. (2007). Genetic disruption of protein kinase A anchoring reveals a role for compartmentalized kinase signaling in theta-burst long-term potentiation and spatial memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

O'Carroll CM, Morris RG. (2004). Heterosynaptic co-activation of glutamatergic and dopaminergic afferents is required to induce persistent long-term potentiation. Neuropharmacology. 47 [PubMed]

Ogreid D, Døskeland SO. (1981). The kinetics of association of cyclic AMP to the two types of binding sites associated with protein kinase II from bovine myocardium. FEBS letters. 129 [PubMed]

Ogreid D, Døskeland SO. (1981). The kinetics of the interaction between cyclic AMP and the regulatory moiety of protein kinase II. Evidence for interaction between the binding sites for cyclic AMP. FEBS letters. 129 [PubMed]

Ogreid D, Døskeland SO. (1982). Activation of protein kinase isoenzymes under near physiological conditions. Evidence that both types (A and B) of cAMP binding sites are involved in the activation of protein kinase by cAMP and 8-N3-cAMP. FEBS letters. 150 [PubMed]

Pantano S, Zaccolo M, Carloni P. (2005). Molecular basis of the allosteric mechanism of cAMP in the regulatory PKA subunit. FEBS letters. 579 [PubMed]

Petrozzino JJ, Pozzo Miller LD, Connor JA. (1995). Micromolar Ca2+ transients in dendritic spines of hippocampal pyramidal neurons in brain slice. Neuron. 14 [PubMed]

Ponsioen B et al. (2004). Detecting cAMP-induced Epac activation by fluorescence resonance energy transfer: Epac as a novel cAMP indicator. EMBO reports. 5 [PubMed]

Rice ME, Cragg SJ. (2004). Nicotine amplifies reward-related dopamine signals in striatum. Nature neuroscience. 7 [PubMed]

Sabatini BL, Oertner TG, Svoboda K. (2002). The life cycle of Ca(2+) ions in dendritic spines. Neuron. 33 [PubMed]

Sajikumar S, Navakkode S, Frey JU. (2007). Identification of compartment- and process-specific molecules required for "synaptic tagging" during long-term potentiation and long-term depression in hippocampal CA1. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Scharf MT et al. (2002). Protein synthesis is required for the enhancement of long-term potentiation and long-term memory by spaced training. Journal of neurophysiology. 87 [PubMed]

Scheuss V, Yasuda R, Sobczyk A, Svoboda K. (2006). Nonlinear [Ca2+] signaling in dendrites and spines caused by activity-dependent depression of Ca2+ extrusion. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Shouval HZ, Bear MF, Cooper LN. (2002). A unified model of NMDA receptor-dependent bidirectional synaptic plasticity. Proceedings of the National Academy of Sciences of the United States of America. 99 [PubMed]

Soulsby MD, Wojcikiewicz RJ. (2005). The type III inositol 1,4,5-trisphosphate receptor is phosphorylated by cAMP-dependent protein kinase at three sites. The Biochemical journal. 392 [PubMed]

Stenesh J. (1993). Core Topic in Biochemistry.

Sweatt JD. (2004). Mitogen-activated protein kinases in synaptic plasticity and memory. Current opinion in neurobiology. 14 [PubMed]

Verney C et al. (1985). Morphological evidence for a dopaminergic terminal field in the hippocampal formation of young and adult rat. Neuroscience. 14 [PubMed]

Vigil D, Blumenthal DK, Brown S, Taylor SS, Trewhella J. (2004). Differential effects of substrate on type I and type II PKA holoenzyme dissociation. Biochemistry. 43 [PubMed]

Wang H, Storm DR. (2003). Calmodulin-regulated adenylyl cyclases: cross-talk and plasticity in the central nervous system. Molecular pharmacology. 63 [PubMed]

Willoughby D, Cooper DM. (2006). Ca2+ stimulation of adenylyl cyclase generates dynamic oscillations in cyclic AMP. Journal of cell science. 119 [PubMed]

Wong ST et al. (1999). Calcium-stimulated adenylyl cyclase activity is critical for hippocampus-dependent long-term memory and late phase LTP. Neuron. 23 [PubMed]

Woo NH, Abel T, Nguyen PV. (2002). Genetic and pharmacological demonstration of a role for cyclic AMP-dependent protein kinase-mediated suppression of protein phosphatases in gating the expression of late LTP. The European journal of neuroscience. 16 [PubMed]

Woo NH, Duffy SN, Abel T, Nguyen PV. (2003). Temporal spacing of synaptic stimulation critically modulates the dependence of LTP on cyclic AMP-dependent protein kinase. Hippocampus. 13 [PubMed]

Young JZ, Isiegas C, Abel T, Nguyen PV. (2006). Metaplasticity of the late-phase of long-term potentiation: a critical role for protein kinase A in synaptic tagging. The European journal of neuroscience. 23 [PubMed]

Zawadzki KM, Taylor SS. (2004). cAMP-dependent protein kinase regulatory subunit type IIbeta: active site mutations define an isoform-specific network for allosteric signaling by cAMP. The Journal of biological chemistry. 279 [PubMed]

Zhabotinsky AM. (2000). Bistability in the Ca(2+)/calmodulin-dependent protein kinase-phosphatase system. Biophysical journal. 79 [PubMed]

Zhabotinsky AM, Camp RN, Epstein IR, Lisman JE. (2006). Role of the neurogranin concentrated in spines in the induction of long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

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