A model of neurovascular coupling and the BOLD response (Mathias et al 2017, Kenny et al 2018)


Mathias EJ, Plank MJ, David T. (2017). A model of neurovascular coupling and the BOLD response: PART I. Computer methods in biomechanics and biomedical engineering. 20 [PubMed]

See more from authors: Mathias EJ · Plank MJ · David T

References and models cited by this paper

Aperia A. (2001). Regulation of sodium/potassium ATPase activity: impact on salt balance and vascular contractility. Current hypertension reports. 3 [PubMed]

Bonder DE, McCarthy KD. (2014). Astrocytic Gq-GPCR-linked IP3R-dependent Ca2+ signaling does not mediate neurovascular coupling in mouse visual cortex in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Buxton RB, Uludağ K, Dubowitz DJ, Liu TT. (2004). Modeling the hemodynamic response to brain activation. NeuroImage. 23 Suppl 1 [PubMed]

Buxton RB, Wong EC, Frank LR. (1998). Dynamics of blood flow and oxygenation changes during brain activation: the balloon model. Magnetic resonance in medicine. 39 [PubMed]

Cannon RO. (1998). Role of nitric oxide in cardiovascular disease: focus on the endothelium. Clinical chemistry. 44 [PubMed]

Chang JC et al. (2013). A mathematical model of the metabolic and perfusion effects on cortical spreading depression. PloS one. 8 [PubMed]

Cloutier M, Bolger FB, Lowry JP, Wellstead P. (2009). An integrative dynamic model of brain energy metabolism using in vivo neurochemical measurements. Journal of computational neuroscience. 27 [PubMed]

Devonshire IM et al. (2012). Neurovascular coupling is brain region-dependent. NeuroImage. 59 [PubMed]

Dormanns K, Brown RG, David T. (2015). Neurovascular coupling: a parallel implementation. Frontiers in computational neuroscience. 9 [PubMed]

Dormanns K, van Disseldorp EM, Brown RG, David T. (2015). Neurovascular coupling and the influence of luminal agonists via the endothelium. Journal of theoretical biology. 364 [PubMed]

Enager P et al. (2009). Pathway-specific variations in neurovascular and neurometabolic coupling in rat primary somatosensory cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 29 [PubMed]

Farr H, David T. (2011). Models of neurovascular coupling via potassium and EET signalling. Journal of theoretical biology. 286 [PubMed]

Filosa JA, Blanco VM. (2007). Neurovascular coupling in the mammalian brain. Experimental physiology. 92 [PubMed]

Filosa JA et al. (2006). Local potassium signaling couples neuronal activity to vasodilation in the brain. Nature neuroscience. 9 [PubMed]

Fox PT, Raichle ME. (1986). Focal physiological uncoupling of cerebral blood flow and oxidative metabolism during somatosensory stimulation in human subjects. Proceedings of the National Academy of Sciences of the United States of America. 83 [PubMed]

Gore RW, Davis MJ. (1984). Mechanics of smooth muscle in isolated single microvessels. Annals of biomedical engineering. 12 [PubMed]

Gusnard DA, Raichle ME, Raichle ME. (2001). Searching for a baseline: functional imaging and the resting human brain. Nature reviews. Neuroscience. 2 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Hai CM, Murphy RA. (1988). Cross-bridge phosphorylation and regulation of latch state in smooth muscle. The American journal of physiology. 254 [PubMed]

Hai CM, Murphy RA. (1989). Ca2+, crossbridge phosphorylation, and contraction. Annual review of physiology. 51 [PubMed]

Hoge RD et al. (1999). Linear coupling between cerebral blood flow and oxygen consumption in activated human cortex. Proceedings of the National Academy of Sciences of the United States of America. 96 [PubMed]

Horiuchi T, Dietrich HH, Hongo K, Dacey RG. (2002). Mechanism of extracellular K+-induced local and conducted responses in cerebral penetrating arterioles. Stroke. 33 [PubMed]

Iadecola C. (2004). Neurovascular regulation in the normal brain and in Alzheimer's disease. Nature reviews. Neuroscience. 5 [PubMed]

Jolivet R, Coggan JS, Allaman I, Magistretti PJ. (2015). Multi-timescale modeling of activity-dependent metabolic coupling in the neuron-glia-vasculature ensemble. PLoS computational biology. 11 [PubMed]

Koenigsberger M, Sauser R, Bény JL, Meister JJ. (2006). Effects of arterial wall stress on vasomotion. Biophysical journal. 91 [PubMed]

Kudryashov N, Chernyavskii I. (2008). Numerical simulation of the process of autoregulation of the arterial blood flow Fluid Dyn.. 43(1)

Laughlin SB, de Ruyter van Steveninck RR, Anderson JC. (1998). The metabolic cost of neural information. Nature neuroscience. 1 [PubMed]

Leithner C, Royl G. (2014). The oxygen paradox of neurovascular coupling. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 34 [PubMed]

Mazel T, Simonová Z, Syková E. (1998). Diffusion heterogeneity and anisotropy in rat hippocampus. Neuroreport. 9 [PubMed]

McBain CJ, Traynelis SF, Dingledine R. (1990). Regional variation of extracellular space in the hippocampus. Science (New York, N.Y.). 249 [PubMed]

Nicholson C, Phillips JM. (1981). Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. The Journal of physiology. 321 [PubMed]

Obata T et al. (2004). Discrepancies between BOLD and flow dynamics in primary and supplementary motor areas: application of the balloon model to the interpretation of BOLD transients. NeuroImage. 21 [PubMed]

Paulson OB, Newman EA. (1987). Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? Science (New York, N.Y.). 237 [PubMed]

Schuster S, Heinrich R. (1996). The regulation of cellular systems.

Traub RD, Jefferys JG, Miles R, Whittington MA, Tóth K. (1994). A branching dendritic model of a rodent CA3 pyramidal neurone. The Journal of physiology. 481 ( Pt 1) [PubMed]

Watzke HH et al. (1991). Factor XSanto Domingo. Evidence that the severe clinical phenotype arises from a mutation blocking secretion. The Journal of clinical investigation. 88 [PubMed]

Willms AR, Baro DJ, Harris-Warrick RM, Guckenheimer J. (1999). An improved parameter estimation method for Hodgkin-Huxley models. Journal of computational neuroscience. 6 [PubMed]

Yacoub E et al. (2001). Investigation of the initial dip in fMRI at 7 Tesla. NMR in biomedicine. 14 [PubMed]

Zamir M, Budwig R. (2002). Physics of pulsatile flow Appl Mech Rev.. 55

Zonta M et al. (2003). Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature neuroscience. 6 [PubMed]

Østby I et al. (2009). Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space. PLoS computational biology. 5 [PubMed]

References and models that cite this paper

Kenny A, Plank MJ, David T. (2018). The role of astrocytic calcium and TRPV4 channels in neurovascular coupling. Journal of computational neuroscience. 44 [PubMed]

See more from authors: Kenny A · Plank MJ · David T

References and models cited by this paper

Attwell D et al. (2010). Glial and neuronal control of brain blood flow. Nature. 468 [PubMed]

Bazargani N, Attwell D. (2016). Astrocyte calcium signaling: the third wave. Nature neuroscience. 19 [PubMed]

Bennett MR, Farnell L, Gibson WG. (2008). Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells. Journal of theoretical biology. 250 [PubMed]

Bennett MR, Farnell L, Gibson WG. (2008). A quantitative model of cortical spreading depression due to purinergic and gap-junction transmission in astrocyte networks. Biophysical journal. 95 [PubMed]

Bonder DE, McCarthy KD. (2014). Astrocytic Gq-GPCR-linked IP3R-dependent Ca2+ signaling does not mediate neurovascular coupling in mouse visual cortex in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Cahoy JD et al. (2008). A transcriptome database for astrocytes, neurons, and oligodendrocytes: a new resource for understanding brain development and function. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Chen BR, Bouchard MB, McCaslin AF, Burgess SA, Hillman EM. (2011). High-speed vascular dynamics of the hemodynamic response. NeuroImage. 54 [PubMed]

Cox DH. (2014). Modeling a Ca(2+) channel/BKCa channel complex at the single-complex level. Biophysical journal. 107 [PubMed]

Dormanns K, Brown RG, David T. (2016). The role of nitric oxide in neurovascular coupling. Journal of theoretical biology. 394 [PubMed]

Dormanns K, van Disseldorp EM, Brown RG, David T. (2015). Neurovascular coupling and the influence of luminal agonists via the endothelium. Journal of theoretical biology. 364 [PubMed]

Drewes LR. (2012). Making connexons in the neurovascular unit. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 32 [PubMed]

Dunn KM, Hill-Eubanks DC, Liedtke WB, Nelson MT. (2013). TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. Proceedings of the National Academy of Sciences of the United States of America. 110 [PubMed]

Enger R et al. (2015). Dynamics of Ionic Shifts in Cortical Spreading Depression. Cerebral cortex (New York, N.Y. : 1991). 25 [PubMed]

Farr H, David T. (2011). Models of neurovascular coupling via potassium and EET signalling. Journal of theoretical biology. 286 [PubMed]

Filosa JA, Bonev AD, Nelson MT. (2004). Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. Circulation research. 95 [PubMed]

Filosa JA et al. (2006). Local potassium signaling couples neuronal activity to vasodilation in the brain. Nature neuroscience. 9 [PubMed]

Fink CC, Slepchenko B, Loew LM. (1999). Determination of time-dependent inositol-1,4,5-trisphosphate concentrations during calcium release in a smooth muscle cell. Biophysical journal. 77 [PubMed]

Girouard H et al. (2010). Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Girouard H, Iadecola C. (2006). Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. Journal of applied physiology (Bethesda, Md. : 1985). 100 [PubMed]

Gonzalez-Fernandez JM, Ermentrout B. (1994). On the origin and dynamics of the vasomotion of small arteries. Mathematical biosciences. 119 [PubMed]

Hamel E. (2006). Perivascular nerves and the regulation of cerebrovascular tone. Journal of applied physiology (Bethesda, Md. : 1985). 100 [PubMed]

Higashimori H, Blanco VM, Tuniki VR, Falck JR, Filosa JA. (2010). Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes. American journal of physiology. Cell physiology. 299 [PubMed]

Iadecola C. (2004). Neurovascular regulation in the normal brain and in Alzheimer's disease. Nature reviews. Neuroscience. 5 [PubMed]

Lauritzen M et al. (2011). Clinical relevance of cortical spreading depression in neurological disorders: migraine, malignant stroke, subarachnoid and intracranial hemorrhage, and traumatic brain injury. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 31 [PubMed]

Lourenço CF et al. (2014). Neurovascular coupling in hippocampus is mediated via diffusion by neuronal-derived nitric oxide. Free radical biology & medicine. 73 [PubMed]

Nakahata K et al. (2006). Vasodilation mediated by inward rectifier K+ channels in cerebral microvessels of hypertensive and normotensive rats. Anesthesia and analgesia. 102 [PubMed]

Nicholson C, Phillips JM. (1981). Ion diffusion modified by tortuosity and volume fraction in the extracellular microenvironment of the rat cerebellum. The Journal of physiology. 321 [PubMed]

Nicholson C, Syková E. (1998). Extracellular space structure revealed by diffusion analysis. Trends in neurosciences. 21 [PubMed]

Nizar K et al. (2013). In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Pietrobon D, Moskowitz MA. (2014). Chaos and commotion in the wake of cortical spreading depression and spreading depolarizations. Nature reviews. Neuroscience. 15 [PubMed]

Syková E, Nicholson C. (2008). Diffusion in brain extracellular space. Physiological reviews. 88 [PubMed]

Witthoft A, Filosa JA, Karniadakis GE. (2013). Potassium buffering in the neurovascular unit: models and sensitivity analysis. Biophysical journal. 105 [PubMed]

Zonta M et al. (2003). Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature neuroscience. 6 [PubMed]

References and models that cite this paper

Dormanns K, Brown RG, David T. (2016). The role of nitric oxide in neurovascular coupling. Journal of theoretical biology. 394 [PubMed]

See more from authors: Dormanns K · Brown RG · David T

References and models cited by this paper

Andersen OS, Krishnamurthy V, Chung S-H. (2007). Biological Membrane Ion Channels: Dynamics, Structure, and Applications.

Attwell D et al. (2010). Glial and neuronal control of brain blood flow. Nature. 468 [PubMed]

Barrio LC, Capel J, Jarillo JA, Castro C, Revilla A. (1997). Species-specific voltage-gating properties of connexin-45 junctions expressed in Xenopus oocytes. Biophysical journal. 73 [PubMed]

Berridge MJ. (2008). Smooth muscle cell calcium activation mechanisms. The Journal of physiology. 586 [PubMed]

Carlson BE, Beard DA. (2011). Mechanical control of cation channels in the myogenic response. American journal of physiology. Heart and circulatory physiology. 301 [PubMed]

Chang JC et al. (2013). A mathematical model of the metabolic and perfusion effects on cortical spreading depression. PloS one. 8 [PubMed]

Charles AC et al. (1992). Intercellular calcium signaling via gap junctions in glioma cells. The Journal of cell biology. 118 [PubMed]

Chen BR, Bouchard MB, McCaslin AF, Burgess SA, Hillman EM. (2011). High-speed vascular dynamics of the hemodynamic response. NeuroImage. 54 [PubMed]

Comerford A, David T. (2008). Computer model of nucleotide transport in a realistic porcine aortic trifurcation. Annals of biomedical engineering. 36 [PubMed]

Comerford A, Plank MJ, David T. (2008). Endothelial nitric oxide synthase and calcium production in arterial geometries: an integrated fluid mechanics/cell model. Journal of biomechanical engineering. 130 [PubMed]

Cui J, Cox DH, Aldrich RW. (1997). Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels. The Journal of general physiology. 109 [PubMed]

David T. (2003). Wall shear stress modulation of ATP/ADP concentration at the endothelium. Annals of biomedical engineering. 31 [PubMed]

Diep HK, Vigmond EJ, Segal SS, Welsh DG. (2005). Defining electrical communication in skeletal muscle resistance arteries: a computational approach. The Journal of physiology. 568 [PubMed]

Drewes LR. (2012). Making connexons in the neurovascular unit. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 32 [PubMed]

Dunn KM, Hill-Eubanks DC, Liedtke WB, Nelson MT. (2013). TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. Proceedings of the National Academy of Sciences of the United States of America. 110 [PubMed]

Edwards FR, Hirst GD, Silverberg GD. (1988). Inward rectification in rat cerebral arterioles; involvement of potassium ions in autoregulation. The Journal of physiology. 404 [PubMed]

Endo M, Tanaka M, Ogawa Y. (1970). Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. Nature. 228 [PubMed]

Farias M, Gorman MW, Savage MV, Feigl EO. (2005). Plasma ATP during exercise: possible role in regulation of coronary blood flow. American journal of physiology. Heart and circulatory physiology. 288 [PubMed]

Farr H, David T. (2011). Models of neurovascular coupling via potassium and EET signalling. Journal of theoretical biology. 286 [PubMed]

Filosa JA, Blanco VM. (2007). Neurovascular coupling in the mammalian brain. Experimental physiology. 92 [PubMed]

Filosa JA, Bonev AD, Nelson MT. (2004). Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. Circulation research. 95 [PubMed]

Filosa JA et al. (2006). Local potassium signaling couples neuronal activity to vasodilation in the brain. Nature neuroscience. 9 [PubMed]

Fujii K, Heistad DD, Faraci FM. (1990). Ionic mechanisms in spontaneous vasomotion of the rat basilar artery in vivo. The Journal of physiology. 430 [PubMed]

Gebremedhin D et al. (2000). Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circulation research. 87 [PubMed]

Girouard H, Iadecola C. (2006). Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. Journal of applied physiology (Bethesda, Md. : 1985). 100 [PubMed]

Goldbeter A, Dupont G, Berridge MJ. (1990). Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 87 [PubMed]

Gonzalez-Fernandez JM, Ermentrout B. (1994). On the origin and dynamics of the vasomotion of small arteries. Mathematical biosciences. 119 [PubMed]

Gore RW, Davis MJ. (1984). Mechanics of smooth muscle in isolated single microvessels. Annals of biomedical engineering. 12 [PubMed]

Haddock RE et al. (2006). Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins 37 and 40. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

Hadfield J, Plank MJ, David T. (2013). Modeling secondary messenger pathways in neurovascular coupling. Bulletin of mathematical biology. 75 [PubMed]

Hai CM, Murphy RA. (1989). Ca2+, crossbridge phosphorylation, and contraction. Annual review of physiology. 51 [PubMed]

Hamel E. (2006). Perivascular nerves and the regulation of cerebrovascular tone. Journal of applied physiology (Bethesda, Md. : 1985). 100 [PubMed]

Harder DR, Roman RJ, Gebremedhin D. (2000). Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes. Acta physiologica Scandinavica. 168 [PubMed]

Iadecola C. (2004). Neurovascular regulation in the normal brain and in Alzheimer's disease. Nature reviews. Neuroscience. 5 [PubMed]

Kapela A, Bezerianos A, Tsoukias NM. (2008). A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: agonist and NO stimulation. Journal of theoretical biology. 253 [PubMed]

Keizer J, De Young GW. (1992). Two roles of Ca2+ in agonist stimulated Ca2+ oscillations. Biophysical journal. 61 [PubMed]

Koenigsberger M, Sauser R, Bény JL, Meister JJ. (2005). Role of the endothelium on arterial vasomotion. Biophysical journal. 88 [PubMed]

Koenigsberger M, Sauser R, Bény JL, Meister JJ. (2006). Effects of arterial wall stress on vasomotion. Biophysical journal. 91 [PubMed]

Lecrux C, Hamel E. (2011). The neurovascular unit in brain function and disease. Acta physiologica (Oxford, England). 203 [PubMed]

Lindauer U, Megow D, Matsuda H, Dirnagl U. (1999). Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex. The American journal of physiology. 277 [PubMed]

Nagelhus EA et al. (1999). Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia. 26 [PubMed]

Nizar K et al. (2013). In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Parthimos D, Edwards DH, Griffith TM. (1999). Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+ oscillators. The American journal of physiology. 277 [PubMed]

Rivadulla C, de Labra C, Grieve KL, Cudeiro J. (2011). Vasomotion and neurovascular coupling in the visual thalamus in vivo. PloS one. 6 [PubMed]

Roy CS, Sherrington CS. (1890). On the Regulation of the Blood-supply of the Brain. The Journal of physiology. 11 [PubMed]

Rzigalinski BA, Blackmore PF, Rosenthal MD. (1996). Arachidonate mobilization is coupled to depletion of intracellular calcium stores and influx of extracellular calcium in differentiated U937 cells. Biochimica et biophysica acta. 1299 [PubMed]

Rücker M, Strobel O, Vollmar B, Roesken F, Menger MD. (2000). Vasomotion in critically perfused muscle protects adjacent tissues from capillary perfusion failure. American journal of physiology. Heart and circulatory physiology. 279 [PubMed]

Sakurai T, Terui N. (2006). Effects of sympathetically induced vasomotion on tissue-capillary fluid exchange. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

Shaikh MA, Wall DJ, David T. (2012). Macro-scale phenomena of arterial coupled cells: a massively parallel simulation. Journal of the Royal Society, Interface. 9 [PubMed]

Stout CE, Costantin JL, Naus CC, Charles AC. (2002). Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. The Journal of biological chemistry. 277 [PubMed]

Wu RS, Marx SO. (2010). The BK potassium channel in the vascular smooth muscle and kidney: a- and ß-subunits. Kidney international. 78 [PubMed]

Yang J, Clark JW, Bryan RM, Robertson CS. (2005). Mathematical modeling of the nitric oxide/cGMP pathway in the vascular smooth muscle cell. American journal of physiology. Heart and circulatory physiology. 289 [PubMed]

Zlokovic BV. (2005). Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends in neurosciences. 28 [PubMed]

Zonta M et al. (2003). Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature neuroscience. 6 [PubMed]

Zou AP et al. (1996). 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. The American journal of physiology. 270 [PubMed]

Østby I et al. (2009). Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space. PLoS computational biology. 5 [PubMed]

References and models that cite this paper

Kenny A, Plank MJ, David T. (2018). The role of astrocytic calcium and TRPV4 channels in neurovascular coupling. Journal of computational neuroscience. 44 [PubMed]

Dormanns K, van Disseldorp EM, Brown RG, David T. (2015). Neurovascular coupling and the influence of luminal agonists via the endothelium. Journal of theoretical biology. 364 [PubMed]

See more from authors: Dormanns K · van Disseldorp EM · Brown RG · David T

References and models cited by this paper

Andersen OS, Krishnamurthy V, Chung S-H. (2007). Biological Membrane Ion Channels: Dynamics, Structure, and Applications.

Attwell D et al. (2010). Glial and neuronal control of brain blood flow. Nature. 468 [PubMed]

Barrio LC, Capel J, Jarillo JA, Castro C, Revilla A. (1997). Species-specific voltage-gating properties of connexin-45 junctions expressed in Xenopus oocytes. Biophysical journal. 73 [PubMed]

Berridge MJ. (2008). Smooth muscle cell calcium activation mechanisms. The Journal of physiology. 586 [PubMed]

Carlson BE, Beard DA. (2011). Mechanical control of cation channels in the myogenic response. American journal of physiology. Heart and circulatory physiology. 301 [PubMed]

Chang JC et al. (2013). A mathematical model of the metabolic and perfusion effects on cortical spreading depression. PloS one. 8 [PubMed]

Charles AC et al. (1992). Intercellular calcium signaling via gap junctions in glioma cells. The Journal of cell biology. 118 [PubMed]

Chen BR, Bouchard MB, McCaslin AF, Burgess SA, Hillman EM. (2011). High-speed vascular dynamics of the hemodynamic response. NeuroImage. 54 [PubMed]

Comerford A, David T. (2008). Computer model of nucleotide transport in a realistic porcine aortic trifurcation. Annals of biomedical engineering. 36 [PubMed]

Comerford A, Plank MJ, David T. (2008). Endothelial nitric oxide synthase and calcium production in arterial geometries: an integrated fluid mechanics/cell model. Journal of biomechanical engineering. 130 [PubMed]

Cui J, Cox DH, Aldrich RW. (1997). Intrinsic voltage dependence and Ca2+ regulation of mslo large conductance Ca-activated K+ channels. The Journal of general physiology. 109 [PubMed]

David T. (2003). Wall shear stress modulation of ATP/ADP concentration at the endothelium. Annals of biomedical engineering. 31 [PubMed]

Diep HK, Vigmond EJ, Segal SS, Welsh DG. (2005). Defining electrical communication in skeletal muscle resistance arteries: a computational approach. The Journal of physiology. 568 [PubMed]

Drewes LR. (2012). Making connexons in the neurovascular unit. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 32 [PubMed]

Dunn KM, Hill-Eubanks DC, Liedtke WB, Nelson MT. (2013). TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. Proceedings of the National Academy of Sciences of the United States of America. 110 [PubMed]

Edwards FR, Hirst GD, Silverberg GD. (1988). Inward rectification in rat cerebral arterioles; involvement of potassium ions in autoregulation. The Journal of physiology. 404 [PubMed]

Endo M, Tanaka M, Ogawa Y. (1970). Calcium induced release of calcium from the sarcoplasmic reticulum of skinned skeletal muscle fibres. Nature. 228 [PubMed]

Farias M, Gorman MW, Savage MV, Feigl EO. (2005). Plasma ATP during exercise: possible role in regulation of coronary blood flow. American journal of physiology. Heart and circulatory physiology. 288 [PubMed]

Farr H, David T. (2011). Models of neurovascular coupling via potassium and EET signalling. Journal of theoretical biology. 286 [PubMed]

Filosa JA, Bonev AD, Nelson MT. (2004). Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. Circulation research. 95 [PubMed]

Filosa JA et al. (2006). Local potassium signaling couples neuronal activity to vasodilation in the brain. Nature neuroscience. 9 [PubMed]

Fujii K, Heistad DD, Faraci FM. (1990). Ionic mechanisms in spontaneous vasomotion of the rat basilar artery in vivo. The Journal of physiology. 430 [PubMed]

Gebremedhin D et al. (2000). Production of 20-HETE and its role in autoregulation of cerebral blood flow. Circulation research. 87 [PubMed]

Girouard H, Iadecola C. (2006). Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. Journal of applied physiology (Bethesda, Md. : 1985). 100 [PubMed]

Goldbeter A, Dupont G, Berridge MJ. (1990). Minimal model for signal-induced Ca2+ oscillations and for their frequency encoding through protein phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 87 [PubMed]

Gonzalez-Fernandez JM, Ermentrout B. (1994). On the origin and dynamics of the vasomotion of small arteries. Mathematical biosciences. 119 [PubMed]

Gore RW, Davis MJ. (1984). Mechanics of smooth muscle in isolated single microvessels. Annals of biomedical engineering. 12 [PubMed]

Haddock RE et al. (2006). Endothelial coordination of cerebral vasomotion via myoendothelial gap junctions containing connexins 37 and 40. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

Hadfield J, Plank MJ, David T. (2013). Modeling secondary messenger pathways in neurovascular coupling. Bulletin of mathematical biology. 75 [PubMed]

Hai CM, Murphy RA. (1989). Ca2+, crossbridge phosphorylation, and contraction. Annual review of physiology. 51 [PubMed]

Hamel E. (2006). Perivascular nerves and the regulation of cerebrovascular tone. Journal of applied physiology (Bethesda, Md. : 1985). 100 [PubMed]

Harder DR, Roman RJ, Gebremedhin D. (2000). Molecular mechanisms controlling nutritive blood flow: role of cytochrome P450 enzymes. Acta physiologica Scandinavica. 168 [PubMed]

Iadecola C. (2004). Neurovascular regulation in the normal brain and in Alzheimer's disease. Nature reviews. Neuroscience. 5 [PubMed]

Kapela A, Bezerianos A, Tsoukias NM. (2008). A mathematical model of Ca2+ dynamics in rat mesenteric smooth muscle cell: agonist and NO stimulation. Journal of theoretical biology. 253 [PubMed]

Keizer J, De Young GW. (1992). Two roles of Ca2+ in agonist stimulated Ca2+ oscillations. Biophysical journal. 61 [PubMed]

Koenigsberger M, Sauser R, Bény JL, Meister JJ. (2005). Role of the endothelium on arterial vasomotion. Biophysical journal. 88 [PubMed]

Koenigsberger M, Sauser R, Bény JL, Meister JJ. (2006). Effects of arterial wall stress on vasomotion. Biophysical journal. 91 [PubMed]

Lecrux C, Hamel E. (2011). The neurovascular unit in brain function and disease. Acta physiologica (Oxford, England). 203 [PubMed]

Lindauer U, Megow D, Matsuda H, Dirnagl U. (1999). Nitric oxide: a modulator, but not a mediator, of neurovascular coupling in rat somatosensory cortex. The American journal of physiology. 277 [PubMed]

Nagelhus EA et al. (1999). Immunogold evidence suggests that coupling of K+ siphoning and water transport in rat retinal Müller cells is mediated by a coenrichment of Kir4.1 and AQP4 in specific membrane domains. Glia. 26 [PubMed]

Nizar K et al. (2013). In vivo stimulus-induced vasodilation occurs without IP3 receptor activation and may precede astrocytic calcium increase. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Parthimos D, Edwards DH, Griffith TM. (1999). Minimal model of arterial chaos generated by coupled intracellular and membrane Ca2+ oscillators. The American journal of physiology. 277 [PubMed]

Rivadulla C, de Labra C, Grieve KL, Cudeiro J. (2011). Vasomotion and neurovascular coupling in the visual thalamus in vivo. PloS one. 6 [PubMed]

Roy CS, Sherrington CS. (1890). On the Regulation of the Blood-supply of the Brain. The Journal of physiology. 11 [PubMed]

Rzigalinski BA, Blackmore PF, Rosenthal MD. (1996). Arachidonate mobilization is coupled to depletion of intracellular calcium stores and influx of extracellular calcium in differentiated U937 cells. Biochimica et biophysica acta. 1299 [PubMed]

Rücker M, Strobel O, Vollmar B, Roesken F, Menger MD. (2000). Vasomotion in critically perfused muscle protects adjacent tissues from capillary perfusion failure. American journal of physiology. Heart and circulatory physiology. 279 [PubMed]

Sakurai T, Terui N. (2006). Effects of sympathetically induced vasomotion on tissue-capillary fluid exchange. American journal of physiology. Heart and circulatory physiology. 291 [PubMed]

Shaikh MA, Wall DJ, David T. (2012). Macro-scale phenomena of arterial coupled cells: a massively parallel simulation. Journal of the Royal Society, Interface. 9 [PubMed]

Stout CE, Costantin JL, Naus CC, Charles AC. (2002). Intercellular calcium signaling in astrocytes via ATP release through connexin hemichannels. The Journal of biological chemistry. 277 [PubMed]

Wu RS, Marx SO. (2010). The BK potassium channel in the vascular smooth muscle and kidney: a- and ß-subunits. Kidney international. 78 [PubMed]

Yang J, Clark JW, Bryan RM, Robertson CS. (2005). Mathematical modeling of the nitric oxide/cGMP pathway in the vascular smooth muscle cell. American journal of physiology. Heart and circulatory physiology. 289 [PubMed]

Zlokovic BV. (2005). Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends in neurosciences. 28 [PubMed]

Zonta M et al. (2003). Neuron-to-astrocyte signaling is central to the dynamic control of brain microcirculation. Nature neuroscience. 6 [PubMed]

Zou AP et al. (1996). 20-HETE is an endogenous inhibitor of the large-conductance Ca(2+)-activated K+ channel in renal arterioles. The American journal of physiology. 270 [PubMed]

Østby I et al. (2009). Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space. PLoS computational biology. 5 [PubMed]

Farr H, David T. (2011). Models of neurovascular coupling via potassium and EET signalling. Journal of theoretical biology. 286 [PubMed]

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References and models cited by this paper

Attwell D et al. (2010). Glial and neuronal control of brain blood flow. Nature. 468 [PubMed]

Bennett MR, Farnell L, Gibson WG. (2008). Origins of blood volume change due to glutamatergic synaptic activity at astrocytes abutting on arteriolar smooth muscle cells. Journal of theoretical biology. 250 [PubMed]

Borisova L, Wray S, Eisner DA, Burdyga T. (2009). How structure, Ca signals, and cellular communications underlie function in precapillary arterioles. Circulation research. 105 [PubMed]

Buerk DG. (2001). Can we model nitric oxide biotransport? A survey of mathematical models for a simple diatomic molecule with surprisingly complex biological activities. Annual review of biomedical engineering. 3 [PubMed]

Cameron IR, Caronna J. (1976). The effect of local changes in potassium and bicarbonate concentration on hypothalamic blood flow in the rabbit. The Journal of physiology. 262 [PubMed]

Carmignoto G, Pasti L, Pozzan T. (1998). On the role of voltage-dependent calcium channels in calcium signaling of astrocytes in situ. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Chen KC, Nicholson C. (2000). Spatial buffering of potassium ions in brain extracellular space. Biophysical journal. 78 [PubMed]

Chrissobolis S, Ziogas J, Chu Y, Faraci FM, Sobey CG. (2000). Role of inwardly rectifying K(+) channels in K(+)-induced cerebral vasodilatation in vivo. American journal of physiology. Heart and circulatory physiology. 279 [PubMed]

Edwards FR, Hirst GD, Silverberg GD. (1988). Inward rectification in rat cerebral arterioles; involvement of potassium ions in autoregulation. The Journal of physiology. 404 [PubMed]

Ehrenstein G, Lecar H. (1977). Electrically gated ionic channels in lipid bilayers. Quarterly reviews of biophysics. 10 [PubMed]

Filosa JA, Blanco VM. (2007). Neurovascular coupling in the mammalian brain. Experimental physiology. 92 [PubMed]

Filosa JA et al. (2006). Local potassium signaling couples neuronal activity to vasodilation in the brain. Nature neuroscience. 9 [PubMed]

Girouard H et al. (2010). Astrocytic endfoot Ca2+ and BK channels determine both arteriolar dilation and constriction. Proceedings of the National Academy of Sciences of the United States of America. 107 [PubMed]

Girouard H, Iadecola C. (2006). Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease. Journal of applied physiology (Bethesda, Md. : 1985). 100 [PubMed]

Golding EM, Steenberg ML, Johnson TD, Bryan RM. (2000). The effects of potassium on the rat middle cerebral artery. Brain research. 880 [PubMed]

Gonzalez-Fernandez JM, Ermentrout B. (1994). On the origin and dynamics of the vasomotion of small arteries. Mathematical biosciences. 119 [PubMed]

Gore RW, Davis MJ. (1984). Mechanics of smooth muscle in isolated single microvessels. Annals of biomedical engineering. 12 [PubMed]

Hai CM, Murphy RA. (1988). Cross-bridge phosphorylation and regulation of latch state in smooth muscle. The American journal of physiology. 254 [PubMed]

Higashi K et al. (2001). An inwardly rectifying K(+) channel, Kir4.1, expressed in astrocytes surrounds synapses and blood vessels in brain. American journal of physiology. Cell physiology. 281 [PubMed]

Higashimori H, Blanco VM, Tuniki VR, Falck JR, Filosa JA. (2010). Role of epoxyeicosatrienoic acids as autocrine metabolites in glutamate-mediated K+ signaling in perivascular astrocytes. American journal of physiology. Cell physiology. 299 [PubMed]

Horiuchi T, Dietrich HH, Hongo K, Dacey RG. (2002). Mechanism of extracellular K+-induced local and conducted responses in cerebral penetrating arterioles. Stroke. 33 [PubMed]

Iadecola C. (2004). Neurovascular regulation in the normal brain and in Alzheimer's disease. Nature reviews. Neuroscience. 5 [PubMed]

Jiang ZG, Si JQ, Lasarev MR, Nuttall AL. (2001). Two resting potential levels regulated by the inward-rectifier potassium channel in the guinea-pig spiral modiolar artery. The Journal of physiology. 537 [PubMed]

Johnson TD, Marrelli SP, Steenberg ML, Childres WF, Bryan RM. (1998). Inward rectifier potassium channels in the rat middle cerebral artery. The American journal of physiology. 274 [PubMed]

Knot HJ, Zimmermann PA, Nelson MT. (1996). Extracellular K(+)-induced hyperpolarizations and dilatations of rat coronary and cerebral arteries involve inward rectifier K(+) channels. The Journal of physiology. 492 ( Pt 2) [PubMed]

Koenigsberger M, Sauser R, Bény JL, Meister JJ. (2006). Effects of arterial wall stress on vasomotion. Biophysical journal. 91 [PubMed]

Kofuji P, Newman EA. (2004). Potassium buffering in the central nervous system. Neuroscience. 129 [PubMed]

Kudryashov N, Chernyavskii I. (2008). Numerical simulation of the process of autoregulation of the arterial blood flow Fluid Dyn.. 43(1)

Kurachi Y. (1985). Voltage-dependent activation of the inward-rectifier potassium channel in the ventricular cell membrane of guinea-pig heart. The Journal of physiology. 366 [PubMed]

Kuschinsky W, Wahl M, Bosse O, Thurau K. (1972). Perivascular potassium and pH as determinants of local pial arterial diameter in cats. A microapplication study. Circulation research. 31 [PubMed]

Lauwers F, Cassot F, Lauwers-Cances V, Puwanarajah P, Duvernoy H. (2008). Morphometry of the human cerebral cortex microcirculation: general characteristics and space-related profiles. NeuroImage. 39 [PubMed]

Lemon G, Gibson WG, Bennett MR. (2003). Metabotropic receptor activation, desensitization and sequestration-I: modelling calcium and inositol 1,4,5-trisphosphate dynamics following receptor activation. Journal of theoretical biology. 223 [PubMed]

Lu T et al. (2001). Dihydroxyeicosatrienoic acids are potent activators of Ca(2+)-activated K(+) channels in isolated rat coronary arterial myocytes. The Journal of physiology. 534 [PubMed]

Matyash V, Kettenmann H. (2010). Heterogeneity in astrocyte morphology and physiology. Brain research reviews. 63 [PubMed]

McCarron JG, Halpern W. (1990). Potassium dilates rat cerebral arteries by two independent mechanisms. The American journal of physiology. 259 [PubMed]

Metea MR, Kofuji P, Newman EA. (2007). Neurovascular coupling is not mediated by potassium siphoning from glial cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Morris C, Lecar H. (1981). Voltage oscillations in the barnacle giant muscle fiber. Biophysical journal. 35 [PubMed]

Nakahata K et al. (2006). Vasodilation mediated by inward rectifier K+ channels in cerebral microvessels of hypertensive and normotensive rats. Anesthesia and analgesia. 102 [PubMed]

Nystoriak MA et al. (2011). Fundamental increase in pressure-dependent constriction of brain parenchymal arterioles from subarachnoid hemorrhage model rats due to membrane depolarization. American journal of physiology. Heart and circulatory physiology. 300 [PubMed]

Paulson OB, Newman EA. (1987). Does the release of potassium from astrocyte endfeet regulate cerebral blood flow? Science (New York, N.Y.). 237 [PubMed]

Price DL, Ludwig JW, Mi H, Schwarz TL, Ellisman MH. (2002). Distribution of rSlo Ca2+-activated K+ channels in rat astrocyte perivascular endfeet. Brain research. 956 [PubMed]

Quayle JM, Dart C, Standen NB. (1996). The properties and distribution of inward rectifier potassium currents in pig coronary arterial smooth muscle. The Journal of physiology. 494 ( Pt 3) [PubMed]

Quayle JM, Nelson MT, Standen NB. (1997). ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiological reviews. 77 [PubMed]

Quinn K, Guibert C, Beech DJ. (2000). Sodium-potassium-ATPase electrogenicity in cerebral precapillary arterioles. American journal of physiology. Heart and circulatory physiology. 279 [PubMed]

Setoguchi M, Ohya Y, Abe I, Fujishima M. (1997). Stretch-activated whole-cell currents in smooth muscle cells from mesenteric resistance artery of guinea-pig. The Journal of physiology. 501 ( Pt 2) [PubMed]

Shampine LF, Bogacki P. (1996). An efficient Runge-Kutta (4,5) pair Comput. Math. Appl.. 32(6)

Shi Y et al. (2008). Interaction of mechanisms involving epoxyeicosatrienoic acids, adenosine receptors, and metabotropic glutamate receptors in neurovascular coupling in rat whisker barrel cortex. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 28 [PubMed]

Siegl D, Koeppen M, Wölfle SE, Pohl U, de Wit C. (2005). Myoendothelial coupling is not prominent in arterioles within the mouse cremaster microcirculation in vivo. Circulation research. 97 [PubMed]

Smeda JS, Payne GW. (2003). Alterations in autoregulatory and myogenic function in the cerebrovasculature of Dahl salt-sensitive rats. Stroke. 34 [PubMed]

Stensaas LJ. (1975). Pericytes and perivascular microglial cells in the basal forebrain of the neonatal rabbit. Cell and tissue research. 158 [PubMed]

Ullah G, Jung P, Cornell-Bell AH. (2006). Anti-phase calcium oscillations in astrocytes via inositol (1, 4, 5)-trisphosphate regeneration. Cell calcium. 39 [PubMed]

Xu G et al. (2007). Perfusion fMRI detects deficits in regional CBF during memory-encoding tasks in MCI subjects. Neurology. 69 [PubMed]

Zhou M, Kimelberg HK. (2000). Freshly isolated astrocytes from rat hippocampus show two distinct current patterns and different [K(+)](o) uptake capabilities. Journal of neurophysiology. 84 [PubMed]

Østby I et al. (2009). Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space. PLoS computational biology. 5 [PubMed]

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