NMDA receptor saturation (Chen et al 2001)


Chen N, Ren J, Raymond LA, Murphy TH. (2001). Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation. Molecular pharmacology. 59 [PubMed]

See more from authors: Chen N · Ren J · Raymond LA · Murphy TH

References and models cited by this paper

Barbour B, Häusser M. (1997). Intersynaptic diffusion of neurotransmitter. Trends in neurosciences. 20 [PubMed]

Benveniste H, Drejer J, Schousboe A, Diemer NH. (1984). Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis. Journal of neurochemistry. 43 [PubMed]

Bergles DE, Jahr CE. (1998). Glial contribution to glutamate uptake at Schaffer collateral-commissural synapses in the hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Chen C, Okayama H. (1987). High-efficiency transformation of mammalian cells by plasmid DNA. Molecular and cellular biology. 7 [PubMed]

Chen N, Luo T, Raymond LA. (1999). Subtype-dependence of NMDA receptor channel open probability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Chen N, Moshaver A, Raymond LA. (1997). Differential sensitivity of recombinant N-methyl-D-aspartate receptor subtypes to zinc inhibition. Molecular pharmacology. 51 [PubMed]

Choi S, Klingauf J, Tsien RW. (2000). Postfusional regulation of cleft glutamate concentration during LTP at 'silent synapses'. Nature neuroscience. 3 [PubMed]

Clements JD. (1996). Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends in neurosciences. 19 [PubMed]

Clements JD, Lester RA, Tong G, Jahr CE, Westbrook GL. (1992). The time course of glutamate in the synaptic cleft. Science (New York, N.Y.). 258 [PubMed]

Clements JD, Westbrook GL. (1991). Activation kinetics reveal the number of glutamate and glycine binding sites on the N-methyl-D-aspartate receptor. Neuron. 7 [PubMed]

Diamond JS, Jahr CE. (1997). Transporters buffer synaptically released glutamate on a submillisecond time scale. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Dingledine R, Borges K, Bowie D, Traynelis SF. (1999). The glutamate receptor ion channels. Pharmacological reviews. 51 [PubMed]

Edmonds B, Colquhoun D. (1992). Rapid decay of averaged single-channel NMDA receptor activations recorded at low agonist concentration. Proceedings. Biological sciences. 250 [PubMed]

Frerking M, Wilson M. (1996). Saturation of postsynaptic receptors at central synapses? Current opinion in neurobiology. 6 [PubMed]

Hessler NA, Shirke AM, Malinow R. (1993). The probability of transmitter release at a mammalian central synapse. Nature. 366 [PubMed]

Hestrin S. (1992). Activation and desensitization of glutamate-activated channels mediating fast excitatory synaptic currents in the visual cortex. Neuron. 9 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Holmes WR. (1995). Modeling the effect of glutamate diffusion and uptake on NMDA and non-NMDA receptor saturation. Biophysical journal. 69 [PubMed]

Jonas P, Sakmann B. (1992). Glutamate receptor channels in isolated patches from CA1 and CA3 pyramidal cells of rat hippocampal slices. The Journal of physiology. 455 [PubMed]

Lester RA, Clements JD, Westbrook GL, Jahr CE. (1990). Channel kinetics determine the time course of NMDA receptor-mediated synaptic currents. Nature. 346 [PubMed]

Lester RA, Jahr CE. (1992). NMDA channel behavior depends on agonist affinity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 12 [PubMed]

Liu G, Dube GR. (1999). AMPA and NMDA receptors display similar affinity during rapid synaptic-like glutamate applications. Soc Neurosci Abstr. 25

Mackenzie PJ, Umemiya M, Murphy TH. (1996). Ca2+ imaging of CNS axons in culture indicates reliable coupling between single action potentials and distal functional release sites. Neuron. 16 [PubMed]

Mainen ZF, Malinow R, Svoboda K. (1999). Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated. Nature. 399 [PubMed]

McAllister AK, Stevens CF. (2000). Nonsaturation of AMPA and NMDA receptors at hippocampal synapses. Proceedings of the National Academy of Sciences of the United States of America. 97 [PubMed]

McLarnon JG, Curry K. (1990). Single channel properties of the N-methyl-D-aspartate receptor channel using NMDA and NMDA agonists: on-cell recordings. Experimental brain research. 82 [PubMed]

Min MY, Rusakov DA, Kullmann DM. (1998). Activation of AMPA, kainate, and metabotropic receptors at hippocampal mossy fiber synapses: role of glutamate diffusion. Neuron. 21 [PubMed]

Patneau DK, Mayer ML. (1990). Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10 [PubMed]

Perkel DJ, Nicoll RA. (1993). Evidence for all-or-none regulation of neurotransmitter release: implications for long-term potentiation. The Journal of physiology. 471 [PubMed]

Racca C, Stephenson FA, Streit P, Roberts JD, Somogyi P. (2000). NMDA receptor content of synapses in stratum radiatum of the hippocampal CA1 area. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Rusakov DA, Kullmann DM, Stewart MG. (1999). Hippocampal synapses: do they talk to their neighbours? Trends in neurosciences. 22 [PubMed]

Sejnowski TJ, Destexhe A, Mainen ZF. (1998). Kinetic models of synaptic transmission Methods In Neuronal Modeling.

Silver RA, Cull-Candy SG, Takahashi T. (1996). Non-NMDA glutamate receptor occupancy and open probability at a rat cerebellar synapse with single and multiple release sites. The Journal of physiology. 494 ( Pt 1) [PubMed]

Somogyi P, Nusser Z, Lujan R, Roberts DB. (1998). Precision and variability in the placement of pre-postsynaptic receptors in relation to transmitter release sites. Central Synapses, Quantal Mechanisms And Plasticity.

Sugihara H, Moriyoshi K, Ishii T, Masu M, Nakanishi S. (1992). Structures and properties of seven isoforms of the NMDA receptor generated by alternative splicing. Biochemical and biophysical research communications. 185 [PubMed]

Tong G, Jahr CE. (1994). Multivesicular release from excitatory synapses of cultured hippocampal neurons. Neuron. 12 [PubMed]

Umemiya M, Senda M, Murphy TH. (1999). Behaviour of NMDA and AMPA receptor-mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging. The Journal of physiology. 521 Pt 1 [PubMed]

Vicini S et al. (1998). Functional and pharmacological differences between recombinant N-methyl-D-aspartate receptors. Journal of neurophysiology. 79 [PubMed]

Vincent P, Marty A. (1996). Fluctuations of inhibitory postsynaptic currents in Purkinje cells from rat cerebellar slices. The Journal of physiology. 494 ( Pt 1) [PubMed]

Vyklicky L, Patneau DK, Mayer ML. (1991). Modulation of excitatory synaptic transmission by drugs that reduce desensitization at AMPA/kainate receptors. Neuron. 7 [PubMed]

Wang LY, MacDonald JF. (1995). Modulation by magnesium of the affinity of NMDA receptors for glycine in murine hippocampal neurones. The Journal of physiology. 486 ( Pt 1) [PubMed]

Williams K. (1993). Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Molecular pharmacology. 44 [PubMed]

Xiong ZG et al. (1998). Regulation of N-methyl-D-aspartate receptor function by constitutively active protein kinase C. Molecular pharmacology. 54 [PubMed]

References and models that cite this paper

Baker JL, Perez-Rosello T, Migliore M, Barrionuevo G, Ascoli GA. (2011). A computer model of unitary responses from associational/commissural and perforant path synapses in hippocampal CA3 pyramidal cells. Journal of computational neuroscience. 31 [PubMed]

Carnevale NT, Hines M. (2003). Personal Communication of NEURON bibliography .

Carnevale NT, Morse TM. (1996). Research reports that have used NEURON Web published citations at the NEURON website.

Chen N, Li B, Murphy TH, Raymond LA. (2004). Site within N-Methyl-D-aspartate receptor pore modulates channel gating. Molecular pharmacology. 65 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.