ModelDB: Models that contain Multiple sclerosis

Model Concept: Multiple sclerosis

A disease in which nerve cells loose their myelin cell coatings which help maintain electrical signaling. Can cause partial or complete paralysis or muscle tremors.

Conduction in uniform myelinated axons (Moore et al 1978)
Demyelinated and remyelinating axon conductances (Hines, Shrager 1991)
Double cable myelinated axon (Layer 5 pyramidal neuron; Cohen et al 2020)

Top authors for Multiple sclerosis:

Moore JW (1)
Joyner RW (1)
Brill MH (1)
Waxman SD (1)
Najar-Joa M (1)
Hines M (1)
Shrager P (1)
Cohen CCH (1)
Popovic MA (1)
Klooster J (1)

Top concepts studied with Multiple sclerosis:

Axonal Action Potentials (3)
Action Potentials (1)
Active Dendrites (1)
Conductance distributions (1)
Conductances estimation (1)
Detailed Neuronal Models (1)
Electrotonus (1)
Extracellular Fields (1)
Membrane Properties (1)
Parameter sensitivity (1)

Top neurons studied with Multiple sclerosis:

Myelinated neuron (2)
Neocortex L5/6 pyramidal GLU cell (1)

Top currents studied with Multiple sclerosis:

I Na,t (3)
I K (2)
Ca pump (1)
I Calcium (1)
I h (1)
I K,Ca (1)
I K,leak (1)
I L high threshold (1)
I T low threshold (1)
I M (1)

Top references cited by these models:

Cooley JW, Dodge FA. (1966). Digital computer solutions for excitation and propagation of the nerve impulse. Biophysical journal. 6 (1)
FRANKENHAEUSER B, HUXLEY AF. (1964). THE ACTION POTENTIAL IN THE MYELINATED NERVE FIBER OF XENOPUS LAEVIS AS COMPUTED ON THE BASIS OF VOLTAGE CLAMP DATA. The Journal of physiology. 171 (1)
Ramón F, Joyner RW, Moore JW. (1975). Propagation of action potentials in inhomogeneous axon regions. Federation proceedings. 34 (1)
Brill MH, Waxman SG, Moore JW, Joyner RW. (1977). Conduction velocity and spike configuration in myelinated fibres: computed dependence on internode distance. Journal of neurology, neurosurgery, and psychiatry. 40 (1)
Moore JW, Ramón F, Joyner RW. (1975). Axon voltage-clamp simulations. I. Methods and tests. Biophysical journal. 15 (1)