Space clamp problems in neurons with voltage-gated conductances (Bar-Yehuda and Korngreen 2008)


" ... using numerical simulations, we show that the distortions of voltage-gated K+ and Ca2+ currents are substantial even in neurons with short dendrites. The simulations also demonstrate that passive cable theory cannot be used to justify voltage-clamping of neurons, due to significant shunting to the reversal potential of the voltage-gated conductance during channel activation. ... "

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Neocortex L5/6 pyramidal GLU cell

Currents: I K; I Calcium

Model Concept(s): Ion Channel Kinetics; Influence of Dendritic Geometry; Detailed Neuronal Models

Simulation Environment: NEURON

Implementer(s): Korngreen, Alon [alon.korngreen at gmail.com]

References:

Bar-Yehuda D, Korngreen A. (2008). Space-clamp problems when voltage clamping neurons expressing voltage-gated conductances. J Neurophysiol 99 [PubMed]