"Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na(+) channels. However, it remains unknown whether it has any effects on K(+) currents. The effects of ACO on ion currents in differentiated clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular myocytes were investigated in this study. ..." The rat action potential in this simulation was played back into the cell for experiments reported in this paper.
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Cardiac ventricular cell
Model Concept(s): Action Potentials
Simulation Environment: XPPAUT
Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]
References:
Wang YJ et al. (2008). Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes. Toxicological sciences : an official journal of the Society of Toxicology. 106 [PubMed]