Tight junction model of CNS myelinated axons (Devaux and Gow 2008)


Two models are included: 1) a myelinated axon is represented by an equivalent circuit with a double cable design but includes a tight junction in parallel with the myelin membrane RC circuit (called double cable model, DCM). 2) a myelinated axon is represented by an equivalent circuit with a double cable design but includes a tight junction in series with the myelin RC circuit (called tight junction model, TJM). These models have been used to simulate data from compound action potentials measured in mouse optic nerve from Claudin 11-null mice in Fig. 6 of: Devaux, J.J. & Gow, A. (2008) Tight Junctions Potentiate The Insulative Properties Of Small CNS Myelinated Axons. J Cell Biol 183, 909-921.

Model Type: Glia

Region(s) or Organism(s): Unknown

Cell Type(s): Myelinated neuron

Currents: I Na,t; I K; I K,leak; I M

Model Concept(s): Axonal Action Potentials

Simulation Environment: NEURON

References:

Devaux J, Gow A. (2008). Tight junctions potentiate the insulative properties of small CNS myelinated axons. J Cell Biol 183 [PubMed]

Gow A, Devaux J. (2008). A model of tight junction function in central nervous system myelinated axons. Neuron Glia Biol 4 [PubMed]