CA1 pyramidal neuron: Dendritic Na+ spikes are required for LTP at distal synapses (Kim et al 2015)


Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N. (2015). Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. eLife. 4 [PubMed]

See more from authors: Kim Y · Hsu CL · Cembrowski MS · Mensh BD · Spruston N

References and models cited by this paper

Ahmed MS, Siegelbaum SA. (2009). Recruitment of N-Type Ca(2+) channels during LTP enhances low release efficacy of hippocampal CA1 perforant path synapses. Neuron. 63 [PubMed]

Amici M et al. (2009). Neuronal calcium sensors and synaptic plasticity. Biochemical Society transactions. 37 [PubMed]

Andrade R. (1991). Blockade of neurotransmitter-activated K+ conductance by QX-314 in the rat hippocampus. European journal of pharmacology. 199 [PubMed]

Andreasen M, Lambert JD. (1995). Regenerative properties of pyramidal cell dendrites in area CA1 of the rat hippocampus. The Journal of physiology. 483 ( Pt 2) [PubMed]

Araya R, Nikolenko V, Eisenthal KB, Yuste R. (2007). Sodium channels amplify spine potentials. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Augustine GJ, Santamaria F, Tanaka K. (2003). Local calcium signaling in neurons. Neuron. 40 [PubMed]

Babiec WE et al. (2014). Ionotropic NMDA receptor signaling is required for the induction of long-term depression in the mouse hippocampal CA1 region. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Basu J et al. (2013). A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. Neuron. 79 [PubMed]

Bittner KC, Andrasfalvy BK, Magee JC. (2012). Ion channel gradients in the apical tuft region of CA1 pyramidal neurons. PloS one. 7 [PubMed]

Blackstone C, Sheng M. (2002). Postsynaptic calcium signaling microdomains in neurons. Frontiers in bioscience : a journal and virtual library. 7 [PubMed]

Bliss TV, Collingridge GL. (1993). A synaptic model of memory: long-term potentiation in the hippocampus. Nature. 361 [PubMed]

Bloodgood BL, Sabatini BL. (2007). Nonlinear regulation of unitary synaptic signals by CaV(2.3) voltage-sensitive calcium channels located in dendritic spines. Neuron. 53 [PubMed]

Bradshaw JM, Kubota Y, Meyer T, Schulman H. (2003). An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein phosphatase 1 switch facilitates specificity in postsynaptic calcium signaling. Proceedings of the National Academy of Sciences of the United States of America. 100 [PubMed]

Brandalise F, Gerber U. (2014). Mossy fiber-evoked subthreshold responses induce timing-dependent plasticity at hippocampal CA3 recurrent synapses. Proceedings of the National Academy of Sciences of the United States of America. 111 [PubMed]

Brette R. (2013). Sharpness of spike initiation in neurons explained by compartmentalization. PLoS computational biology. 9 [PubMed]

Buchanan KA, Mellor JR. (2007). The development of synaptic plasticity induction rules and the requirement for postsynaptic spikes in rat hippocampal CA1 pyramidal neurones. The Journal of physiology. 585 [PubMed]

Burnashev N, Zhou Z, Neher E, Sakmann B. (1995). Fractional calcium currents through recombinant GluR channels of the NMDA, AMPA and kainate receptor subtypes. The Journal of physiology. 485 ( Pt 2) [PubMed]

Buzsáki G, Moser EI. (2013). Memory, navigation and theta rhythm in the hippocampal-entorhinal system. Nature neuroscience. 16 [PubMed]

COOMBS JS, CURTIS DR, ECCLES JC. (1957). The generation of impulses in motoneurones. The Journal of physiology. 139 [PubMed]

Cavazzini M, Bliss T, Emptage N. (2005). Ca2+ and synaptic plasticity. Cell calcium. 38 [PubMed]

Clark BA, Monsivais P, Branco T, London M, Häusser M. (2005). The site of action potential initiation in cerebellar Purkinje neurons. Nature neuroscience. 8 [PubMed]

Colbert CM, Levy WB. (1993). Long-term potentiation of perforant path synapses in hippocampal CA1 in vitro. Brain research. 606 [PubMed]

Cooper SJ. (2005). Donald O. Hebb's synapse and learning rule: a history and commentary. Neuroscience and biobehavioral reviews. 28 [PubMed]

Dudman JT, Tsay D, Siegelbaum SA. (2007). A role for synaptic inputs at distal dendrites: instructive signals for hippocampal long-term plasticity. Neuron. 56 [PubMed]

Eggermann E, Bucurenciu I, Goswami SP, Jonas P. (2011). Nanodomain coupling between Ca²? channels and sensors of exocytosis at fast mammalian synapses. Nature reviews. Neuroscience. 13 [PubMed]

Faas GC, Raghavachari S, Lisman JE, Mody I. (2011). Calmodulin as a direct detector of Ca2+ signals. Nature neuroscience. 14 [PubMed]

Fan Y et al. (2005). Activity-dependent decrease of excitability in rat hippocampal neurons through increases in I(h). Nature neuroscience. 8 [PubMed]

Feldman DE. (2012). The spike-timing dependence of plasticity. Neuron. 75 [PubMed]

Frank LM, Stanley GB, Brown EN. (2004). Hippocampal plasticity across multiple days of exposure to novel environments. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Froemke RC, Letzkus JJ, Kampa BM, Hang GB, Stuart GJ. (2010). Dendritic synapse location and neocortical spike-timing-dependent plasticity. Frontiers in synaptic neuroscience. 2 [PubMed]

Gambino F et al. (2014). Sensory-evoked LTP driven by dendritic plateau potentials in vivo. Nature. 515 [PubMed]

Garaschuk O, Schneggenburger R, Schirra C, Tempia F, Konnerth A. (1996). Fractional Ca2+ currents through somatic and dendritic glutamate receptor channels of rat hippocampal CA1 pyramidal neurones. The Journal of physiology. 491 ( Pt 3) [PubMed]

Golding NL, Jung HY, Mickus T, Spruston N. (1999). Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Golding NL, Kath WL, Spruston N. (2001). Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites. Journal of neurophysiology. 86 [PubMed]

Golding NL, Mickus TJ, Katz Y, Kath WL, Spruston N. (2005). Factors mediating powerful voltage attenuation along CA1 pyramidal neuron dendrites. The Journal of physiology. 568 [PubMed]

Golding NL, Spruston N. (1998). Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron. 21 [PubMed]

Golding NL, Staff NP, Spruston N. (2002). Dendritic spikes as a mechanism for cooperative long-term potentiation. Nature. 418 [PubMed]

Gordon U, Polsky A, Schiller J. (2006). Plasticity compartments in basal dendrites of neocortical pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Gustafsson B, Wigström H, Abraham WC, Huang YY. (1987). Long-term potentiation in the hippocampus using depolarizing current pulses as the conditioning stimulus to single volley synaptic potentials. The Journal of neuroscience : the official journal of the Society for Neuroscience. 7 [PubMed]

Han EB, Heinemann SF. (2013). Distal dendritic inputs control neuronal activity by heterosynaptic potentiation of proximal inputs. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Hardie J, Spruston N. (2009). Synaptic depolarization is more effective than back-propagating action potentials during induction of associative long-term potentiation in hippocampal pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Helmchen F, Imoto K, Sakmann B. (1996). Ca2+ buffering and action potential-evoked Ca2+ signaling in dendrites of pyramidal neurons. Biophysical journal. 70 [PubMed]

Henneberger C, Papouin T, Oliet SH, Rusakov DA. (2010). Long-term potentiation depends on release of D-serine from astrocytes. Nature. 463 [PubMed]

Hestrin S, Sah P, Nicoll RA. (1990). Mechanisms generating the time course of dual component excitatory synaptic currents recorded in hippocampal slices. Neuron. 5 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hines ML, Carnevale NT. (2000). Expanding NEURON's repertoire of mechanisms with NMODL. Neural computation. 12 [PubMed]

Hoffman DA, Magee JC, Colbert CM, Johnston D. (1997). K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature. 387 [PubMed]

Holthoff K, Kovalchuk Y, Konnerth A. (2006). Dendritic spikes and activity-dependent synaptic plasticity. Cell and tissue research. 326 [PubMed]

Hsu CL, Yang HW, Yen CT, Min MY. (2010). Comparison of synaptic transmission and plasticity between sensory and cortical synapses on relay neurons in the ventrobasal nucleus of the rat thalamus. The Journal of physiology. 588 [PubMed]

Hsu CL, Yang HW, Yen CT, Min MY. (2012). A requirement of low-threshold calcium spike for induction of spike-timing-dependent plasticity at corticothalamic synapses on relay neurons in the ventrobasal nucleus of rat thalamus. The Chinese journal of physiology. 55 [PubMed]

Huang H, Trussell LO. (2014). Presynaptic HCN channels regulate vesicular glutamate transport. Neuron. 84 [PubMed]

Isaac JT, Nicoll RA, Malenka RC. (1995). Evidence for silent synapses: implications for the expression of LTP. Neuron. 15 [PubMed]

Jarsky T, Roxin A, Kath WL, Spruston N. (2005). Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Nature neuroscience. 8 [PubMed]

Kaczmarek LK. (2006). Non-conducting functions of voltage-gated ion channels. Nature reviews. Neuroscience. 7 [PubMed]

Kampa BM, Letzkus JJ, Stuart GJ. (2007). Dendritic mechanisms controlling spike-timing-dependent synaptic plasticity. Trends in neurosciences. 30 [PubMed]

Kaneda M, Oyama Y, Ikemoto Y, Akaike N. (1989). Blockade of the voltage-dependent sodium current in isolated rat hippocampal neurons by tetrodotoxin and lidocaine. Brain research. 484 [PubMed]

Kato HK, Watabe AM, Manabe T. (2009). Non-Hebbian synaptic plasticity induced by repetitive postsynaptic action potentials. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Katz Y et al. (2009). Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Neuron. 63 [PubMed]

Khaliq ZM, Raman IM. (2006). Relative contributions of axonal and somatic Na channels to action potential initiation in cerebellar Purkinje neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Koch C, Adams PR, Yamada WM. (1989). Multiple channels and calcium dynamics Methods In Neuronal Modeling: From Synapses To Networks.

Kole MH, Stuart GJ. (2008). Is action potential threshold lowest in the axon? Nature neuroscience. 11 [PubMed]

Kunz PA, Roberts AC, Philpot BD. (2013). Presynaptic NMDA receptor mechanisms for enhancing spontaneous neurotransmitter release. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Lambert NA, Wilson WA. (1993). Discrimination of post- and presynaptic GABAB receptor-mediated responses by tetrahydroaminoacridine in area CA3 of the rat hippocampus. Journal of neurophysiology. 69 [PubMed]

Larkum ME, Nevian T. (2008). Synaptic clustering by dendritic signalling mechanisms. Current opinion in neurobiology. 18 [PubMed]

Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J. (2009). Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science (New York, N.Y.). 325 [PubMed]

Larkum ME, Zhu JJ, Sakmann B. (1999). A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature. 398 [PubMed]

Larson J, Wong D, Lynch G. (1986). Patterned stimulation at the theta frequency is optimal for the induction of hippocampal long-term potentiation. Brain research. 368 [PubMed]

Lee D, Lin BJ, Lee AK. (2012). Hippocampal place fields emerge upon single-cell manipulation of excitability during behavior. Science (New York, N.Y.). 337 [PubMed]

Liao D, Hessler NA, Malinow R. (1995). Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice. Nature. 375 [PubMed]

Lisman J, Yasuda R, Raghavachari S. (2012). Mechanisms of CaMKII action in long-term potentiation. Nature reviews. Neuroscience. 13 [PubMed]

Lorincz A, Nusser Z. (2010). Molecular identity of dendritic voltage-gated sodium channels. Science (New York, N.Y.). 328 [PubMed]

Losonczy A, Magee JC. (2006). Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. Neuron. 50 [PubMed]

Losonczy A, Makara JK, Magee JC. (2008). Compartmentalized dendritic plasticity and input feature storage in neurons. Nature. 452 [PubMed]

Lynch G, Larson J, Kelso S, Barrionuevo G, Schottler F. (1983). Intracellular injections of EGTA block induction of hippocampal long-term potentiation. Nature. 305 [PubMed]

Mackenzie PJ, Murphy TH. (1998). High safety factor for action potential conduction along axons but not dendrites of cultured hippocampal and cortical neurons. Journal of neurophysiology. 80 [PubMed]

Madeja M. (2000). Do neurons have a reserve of sodium channels for the generation of action potentials? A study on acutely isolated CA1 neurons from the guinea-pig hippocampus. The European journal of neuroscience. 12 [PubMed]

Madison DV, Malenka RC, Nicoll RA. (1991). Mechanisms underlying long-term potentiation of synaptic transmission. Annual review of neuroscience. 14 [PubMed]

Maex R, De Schutter E. (1998). Synchronization of golgi and granule cell firing in a detailed network model of the cerebellar granule cell layer. Journal of neurophysiology. 80 [PubMed]

Magee JC, Carruth M. (1999). Dendritic voltage-gated ion channels regulate the action potential firing mode of hippocampal CA1 pyramidal neurons. Journal of neurophysiology. 82 [PubMed]

Magee JC, Johnston D. (1995). Characterization of single voltage-gated Na+ and Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons. The Journal of physiology. 487 [PubMed]

Magee JC, Johnston D. (1997). A synaptically controlled, associative signal for Hebbian plasticity in hippocampal neurons. Science (New York, N.Y.). 275 [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ. (1995). A model of spike initiation in neocortical pyramidal neurons. Neuron. 15 [PubMed]

Major G, Larkum ME, Schiller J. (2013). Active properties of neocortical pyramidal neuron dendrites. Annual review of neuroscience. 36 [PubMed]

Makara JK, Losonczy A, Wen Q, Magee JC. (2009). Experience-dependent compartmentalized dendritic plasticity in rat hippocampal CA1 pyramidal neurons. Nature neuroscience. 12 [PubMed]

Makino H, Malinow R. (2011). Compartmentalized versus global synaptic plasticity on dendrites controlled by experience. Neuron. 72 [PubMed]

Malenka RC, Bear MF. (2004). LTP and LTD: an embarrassment of riches. Neuron. 44 [PubMed]

Maravall M, Mainen ZF, Sabatini BL, Svoboda K. (2000). Estimating intracellular calcium concentrations and buffering without wavelength ratioing. Biophysical journal. 78 [PubMed]

Martin C, Ashley R, Shoshan-Barmatz V. (1993). The effect of local anaesthetics on the ryanodine receptor/Ca2+ release channel of brain microsomal membranes. FEBS letters. 328 [PubMed]

Mehta MR. (2004). Cooperative LTP can map memory sequences on dendritic branches. Trends in neurosciences. 27 [PubMed]

Migliore M, Hoffman DA, Magee JC, Johnston D. (1999). Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. Journal of computational neuroscience. 7 [PubMed]

Morris RG. (1989). Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D-aspartate receptor antagonist AP5. The Journal of neuroscience : the official journal of the Society for Neuroscience. 9 [PubMed]

Nabavi S et al. (2013). Metabotropic NMDA receptor function is required for NMDA receptor-dependent long-term depression. Proceedings of the National Academy of Sciences of the United States of America. 110 [PubMed]

Nathan T, Jensen MS, Lambert JD. (1990). The slow inhibitory postsynaptic potential in rat hippocampal CA1 neurones is blocked by intracellular injection of QX-314. Neuroscience letters. 110 [PubMed]

Oda M, Yoshida A, Ikemoto Y. (1992). Blockade by local anaesthetics of the single Ca(2+)-activated K+ channel in rat hippocampal neurones. British journal of pharmacology. 105 [PubMed]

Otis TS, De Koninck Y, Mody I. (1993). Characterization of synaptically elicited GABAB responses using patch-clamp recordings in rat hippocampal slices. The Journal of physiology. 463 [PubMed]

Otmakhova NA, Otmakhov N, Lisman JE. (2002). Pathway-specific properties of AMPA and NMDA-mediated transmission in CA1 hippocampal pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Perkins KL, Wong RK. (1995). Intracellular QX-314 blocks the hyperpolarization-activated inward current Iq in hippocampal CA1 pyramidal cells. Journal of neurophysiology. 73 [PubMed]

Phillips KG, Hardingham NR, Fox K. (2008). Postsynaptic action potentials are required for nitric-oxide-dependent long-term potentiation in CA1 neurons of adult GluR1 knock-out and wild-type mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron. 37 [PubMed]

Poirazi P, Mel BW. (2001). Impact of active dendrites and structural plasticity on the memory capacity of neural tissue. Neuron. 29 [PubMed]

Raastad M, Shepherd GM. (2003). Single-axon action potentials in the rat hippocampal cortex. The Journal of physiology. 548 [PubMed]

Remondes M, Schuman EM. (2002). Direct cortical input modulates plasticity and spiking in CA1 pyramidal neurons. Nature. 416 [PubMed]

Remondes M, Schuman EM. (2003). Molecular mechanisms contributing to long-lasting synaptic plasticity at the temporoammonic-CA1 synapse. Learning & memory (Cold Spring Harbor, N.Y.). 10 [PubMed]

Remy S, Csicsvari J, Beck H. (2009). Activity-dependent control of neuronal output by local and global dendritic spike attenuation. Neuron. 61 [PubMed]

Remy S, Spruston N. (2007). Dendritic spikes induce single-burst long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Sabatini BL, Oertner TG, Svoboda K. (2002). The life cycle of Ca(2+) ions in dendritic spines. Neuron. 33 [PubMed]

Schiller J, Major G, Koester HJ, Schiller Y. (2000). NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature. 404 [PubMed]

Schiller J, Schiller Y, Stuart G, Sakmann B. (1997). Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. The Journal of physiology. 505 ( Pt 3) [PubMed]

Schmidt H, Stiefel KM, Racay P, Schwaller B, Eilers J. (2003). Mutational analysis of dendritic Ca2+ kinetics in rodent Purkinje cells: role of parvalbumin and calbindin D28k. The Journal of physiology. 551 [PubMed]

Schneggenburger R, Zhou Z, Konnerth A, Neher E. (1993). Fractional contribution of calcium to the cation current through glutamate receptor channels. Neuron. 11 [PubMed]

Schwartzkroin PA, Slawsky M. (1977). Probable calcium spikes in hippocampal neurons. Brain research. 135 [PubMed]

Shatz CJ. (1992). The developing brain. Scientific American. 267 [PubMed]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA. (2007). Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of neurophysiology. 97 [PubMed]

Smith SL, Smith IT, Branco T, Häusser M. (2013). Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature. 503 [PubMed]

Spruston N. (2008). Pyramidal neurons: dendritic structure and synaptic integration. Nature reviews. Neuroscience. 9 [PubMed]

Spruston N, Jonas P, Sakmann B. (1995). Dendritic glutamate receptor channels in rat hippocampal CA3 and CA1 pyramidal neurons. The Journal of physiology. 482 ( Pt 2) [PubMed]

Spruston N, Schiller Y, Stuart G, Sakmann B. (1995). Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science (New York, N.Y.). 268 [PubMed]

Stuart GJ, Sakmann B. (1994). Active propagation of somatic action potentials into neocortical pyramidal cell dendrites. Nature. 367 [PubMed]

Tadross MR, Tsien RW, Yue DT. (2013). Ca2+ channel nanodomains boost local Ca2+ amplitude. Proceedings of the National Academy of Sciences of the United States of America. 110 [PubMed]

Takahashi H, Magee JC. (2009). Pathway interactions and synaptic plasticity in the dendritic tuft regions of CA1 pyramidal neurons. Neuron. 62 [PubMed]

Talbot MJ, Sayer RJ. (1996). Intracellular QX-314 inhibits calcium currents in hippocampal CA1 pyramidal neurons. Journal of neurophysiology. 76 [PubMed]

Thomas MJ, Watabe AM, Moody TD, Makhinson M, O'Dell TJ. (1998). Postsynaptic complex spike bursting enables the induction of LTP by theta frequency synaptic stimulation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Tsay D, Dudman JT, Siegelbaum SA. (2007). HCN1 channels constrain synaptically evoked Ca2+ spikes in distal dendrites of CA1 pyramidal neurons. Neuron. 56 [PubMed]

Tsien RY. (1980). New calcium indicators and buffers with high selectivity against magnesium and protons: design, synthesis, and properties of prototype structures. Biochemistry. 19 [PubMed]

Watkins JC, Olverman HJ. (1987). Agonists and antagonists for excitatory amino acid receptors. Trends Neurosci. 10

Williams SR, Wozny C, Mitchell SJ. (2007). The back and forth of dendritic plasticity. Neuron. 56 [PubMed]

Wittenberg GM, Wang SS. (2006). Malleability of spike-timing-dependent plasticity at the CA3-CA1 synapse. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Wu XE, Mel BW. (2009). Capacity-enhancing synaptic learning rules in a medial temporal lobe online learning model. Neuron. 62 [PubMed]

Xu JY, Zhang J, Chen C. (2012). Long-lasting potentiation of hippocampal synaptic transmission by direct cortical input is mediated via endocannabinoids. The Journal of physiology. 590 [PubMed]

Yu Y, Shu Y, McCormick DA. (2008). Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

References and models that cite this paper

Bloss EB et al. (2016). Structured Dendritic Inhibition Supports Branch-Selective Integration in CA1 Pyramidal Cells. Neuron. 89 [PubMed]

Bloss EB et al. (2018). Single excitatory axons form clustered synapses onto CA1 pyramidal cell dendrites. Nature neuroscience. 21 [PubMed]

Bono J, Clopath C. (2017). Modeling somatic and dendritic spike mediated plasticity at the single neuron and network level. Nature communications. 8 [PubMed]

Górski T et al. (2018). Dendritic sodium spikes endow neurons with inverse firing rate response to correlated synaptic activity. Journal of computational neuroscience. 45 [PubMed]

Hsu CL, Zhao X, Milstein AD, Spruston N. (2018). Persistent sodium current mediates the steep voltage dependence of spatial coding in hippocampal pyramidal neurons Neuron. 99

Podlaski WF et al. (2017). Mapping the function of neuronal ion channels in model and experiment. eLife. 6 [PubMed]

Tomko M, Benuskova L, Jedlicka P. (2021). A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit. Scientific reports. 11 [PubMed]

Ujfalussy BB, Makara JK, Lengyel M, Branco T. (2018). Global and Multiplexed Dendritic Computations under In Vivo-like Conditions. Neuron. 100 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.