Intracortical synaptic potential modulation by presynaptic somatic potential (Shu et al. 2006, 2007)


Shu Y, Duque A, Yu Y, Haider B, McCormick DA. (2007). Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of neurophysiology. 97 [PubMed]

See more from authors: Shu Y · Duque A · Yu Y · Haider B · McCormick DA

References and models cited by this paper

Ariav G, Polsky A, Schiller J. (2003). Submillisecond precision of the input-output transformation function mediated by fast sodium dendritic spikes in basal dendrites of CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Azouz R, Gray CM. (1999). Cellular mechanisms contributing to response variability of cortical neurons in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Binzegger T, Douglas RJ, Martin KA. (2005). Axons in cat visual cortex are topologically self-similar. Cerebral cortex (New York, N.Y. : 1991). 15 [PubMed]

Buzsáki G, Kandel A. (1998). Somadendritic backpropagation of action potentials in cortical pyramidal cells of the awake rat. Journal of neurophysiology. 79 [PubMed]

COOMBS JS, CURTIS DR, ECCLES JC. (1957). The interpretation of spike potentials of motoneurones. The Journal of physiology. 139 [PubMed]

Clark BA, Monsivais P, Branco T, London M, Häusser M. (2005). The site of action potential initiation in cerebellar Purkinje neurons. Nature neuroscience. 8 [PubMed]

Colbert CM, Johnston D. (1996). Axonal action-potential initiation and Na+ channel densities in the soma and axon initial segment of subicular pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Colbert CM, Pan E. (2002). Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nature neuroscience. 5 [PubMed]

Crochet S, Fuentealba P, Timofeev I, Steriade M. (2004). Selective amplification of neocortical neuronal output by fast prepotentials in vivo. Cerebral cortex (New York, N.Y. : 1991). 14 [PubMed]

Destexhe A, Rudolph M, Fellous JM, Sejnowski TJ. (2001). Fluctuating synaptic conductances recreate in vivo-like activity in neocortical neurons. Neuroscience. 107 [PubMed]

Dodson PD et al. (2003). Presynaptic rat Kv1.2 channels suppress synaptic terminal hyperexcitability following action potential invasion. The Journal of physiology. 550 [PubMed]

Eriksson M et al. (2003). Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature. 423 [PubMed]

FUORTES MG, FRANK K, BECKER MC. (1957). Steps in the production of motoneuron spikes. The Journal of general physiology. 40 [PubMed]

Fairén A, Peters A, Saldanha J. (1977). A new procedure for examining Golgi impregnated neurons by light and electron microscopy. Journal of neurocytology. 6 [PubMed]

Fan W, Boston BA, Kesterson RA, Hruby VJ, Cone RD. (1997). Role of melanocortinergic neurons in feeding and the agouti obesity syndrome. Nature. 385 [PubMed]

Fariñas I, DeFelipe J. (1991). Patterns of synaptic input on corticocortical and corticothalamic cells in the cat visual cortex. II. The axon initial segment. The Journal of comparative neurology. 304 [PubMed]

Fraher JP, Kaar GF. (1984). The transitional node of Ranvier at the junction of the central and peripheral nervous systems: an ultrastructural study of its development and mature form. J Anat. 139 ( Pt 2)

Fricker D, Verheugen JA, Miles R. (1999). Cell-attached measurements of the firing threshold of rat hippocampal neurones. The Journal of physiology. 517 ( Pt 3) [PubMed]

Gallyas F. (1979). Silver staining of myelin by means of physical development. Neurological research. 1 [PubMed]

Gasparini S, Migliore M, Magee JC. (2004). On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Golding NL, Spruston N. (1998). Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron. 21 [PubMed]

Haider B, Duque A, Hasenstaub AR, McCormick DA. (2006). Neocortical network activity in vivo is generated through a dynamic balance of excitation and inhibition. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Helmchen F, Svoboda K, Denk W, Tank DW. (1999). In vivo dendritic calcium dynamics in deep-layer cortical pyramidal neurons. Nature neuroscience. 2 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Inda MC, DeFelipe J, Muñoz A. (2006). Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Jarsky T, Roxin A, Kath WL, Spruston N. (2005). Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Nature neuroscience. 8 [PubMed]

Kampa BM, Stuart GJ. (2006). Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Kim HG, Connors BW. (1993). Apical dendrites of the neocortex: correlation between sodium- and calcium-dependent spiking and pyramidal cell morphology. The Journal of neuroscience : the official journal of the Society for Neuroscience. 13 [PubMed]

Kloosterman F, Peloquin P, Leung LS. (2001). Apical and basal orthodromic population spikes in hippocampal CA1 in vivo show different origins and patterns of propagation. Journal of neurophysiology. 86 [PubMed]

Komada M, Soriano P. (2002). [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. The Journal of cell biology. 156 [PubMed]

Kurts C et al. (1999). Signalling through CD30 protects against autoimmune diabetes mediated by CD8 T cells. Nature. 398 [PubMed]

Larkman AU. (1991). Dendritic morphology of pyramidal neurones of the visual cortex of the rat: II. Parameter correlations. The Journal of comparative neurology. 306 [PubMed]

Larkum ME, Kaiser KM, Sakmann B. (1999). Calcium electrogenesis in distal apical dendrites of layer 5 pyramidal cells at a critical frequency of back-propagating action potentials. Proceedings of the National Academy of Sciences of the United States of America. 96 [PubMed]

Larkum ME, Zhu JJ. (2002). Signaling of layer 1 and whisker-evoked Ca2+ and Na+ action potentials in distal and terminal dendrites of rat neocortical pyramidal neurons in vitro and in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Larkum ME, Zhu JJ, Sakmann B. (2001). Dendritic mechanisms underlying the coupling of the dendritic with the axonal action potential initiation zone of adult rat layer 5 pyramidal neurons. The Journal of physiology. 533 [PubMed]

Losonczy A, Magee JC. (2006). Integrative properties of radial oblique dendrites in hippocampal CA1 pyramidal neurons. Neuron. 50 [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ. (1995). A model of spike initiation in neocortical pyramidal neurons. Neuron. 15 [PubMed]

McCormick DA, Connors BW, Lighthall JW, Prince DA. (1985). Comparative electrophysiology of pyramidal and sparsely spiny stellate neurons of the neocortex. Journal of neurophysiology. 54 [PubMed]

McCormick DA, Contreras D. (2001). On the cellular and network bases of epileptic seizures. Annual review of physiology. 63 [PubMed]

McCormick DA, Shu Y, Yu Y. (2007). Neurophysiology: Hodgkin and Huxley model--still standing? Nature. 445 [PubMed]

Meeks JP, Jiang X, Mennerick S. (2005). Action potential fidelity during normal and epileptiform activity in paired soma-axon recordings from rat hippocampus. The Journal of physiology. 566 [PubMed]

Millhouse OE. (1981). The Golgi Methods Neuroanatomical Tract-Tracing Methods.

Milojkovic BA, Wuskell JP, Loew LM, Antic SD. (2005). Initiation of sodium spikelets in basal dendrites of neocortical pyramidal neurons. The Journal of membrane biology. 208 [PubMed]

Naundorf B, Wolf F, Volgushev M. (2006). Unique features of action potential initiation in cortical neurons. Nature. 440 [PubMed]

Noebels JL, Prince DA. (1978). Development of focal seizures in cerebral cortex: role of axon terminal bursting. Journal of neurophysiology. 41 [PubMed]

Nowak LG, Azouz R, Sanchez-Vives MV, Gray CM, McCormick DA. (2003). Electrophysiological classes of cat primary visual cortical neurons in vivo as revealed by quantitative analyses. Journal of neurophysiology. 89 [PubMed]

Nowak LG, Sanchez-Vives MV, McCormick DA. (2005). Role of synaptic and intrinsic membrane properties in short-term receptive field dynamics in cat area 17. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Palay SL, Sotelo C, Peters A, Orkand PM. (1968). The axon hillock and the initial segment. The Journal of cell biology. 38 [PubMed]

Palmer LM, Stuart GJ. (2006). Site of action potential initiation in layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Polsky A, Mel BW, Schiller J. (2004). Computational subunits in thin dendrites of pyramidal cells. Nature neuroscience. 7 [PubMed]

Qiao Y, Molina H, Pandey A, Zhang J, Cole PA. (2006). Chemical rescue of a mutant enzyme in living cells. Science (New York, N.Y.). 311 [PubMed]

Regehr W, Kehoe JS, Ascher P, Armstrong C. (1993). Synaptically triggered action potentials in dendrites. Neuron. 11 [PubMed]

Sanchez-Vives MV, McCormick DA. (2000). Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nature neuroscience. 3 [PubMed]

Schiller J, Schiller Y, Stuart G, Sakmann B. (1997). Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. The Journal of physiology. 505 ( Pt 3) [PubMed]

Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA. (2003). Barrages of synaptic activity control the gain and sensitivity of cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA. (2006). Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature. 441 [PubMed]

Sloper JJ, Powell TP. (1979). A study of the axon initial segment and proximal axon of neurons in the primate motor and somatic sensory cortices. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 285 [PubMed]

Steriade M, Nuñez A, Amzica F. (1993). A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. The Journal of neuroscience : the official journal of the Society for Neuroscience. 13 [PubMed]

Steriade M, Timofeev I, Grenier F. (2001). Natural waking and sleep states: a view from inside neocortical neurons. Journal of neurophysiology. 85 [PubMed]

Stuart G, Schiller J, Sakmann B. (1997). Action potential initiation and propagation in rat neocortical pyramidal neurons. The Journal of physiology. 505 ( Pt 3) [PubMed]

Stuart G, Spruston N, Sakmann B, Häusser M. (1997). Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends in neurosciences. 20 [PubMed]

Svoboda K, Helmchen F, Denk W, Tank DW. (1999). Spread of dendritic excitation in layer 2/3 pyramidal neurons in rat barrel cortex in vivo. Nature neuroscience. 2 [PubMed]

Turner RW, Meyers DE, Richardson TL, Barker JL. (1991). The site for initiation of action potential discharge over the somatodendritic axis of rat hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 11 [PubMed]

Wagner N et al. (1996). Critical role for beta7 integrins in formation of the gut-associated lymphoid tissue. Nature. 382 [PubMed]

Wang XJ. (1999). Fast burst firing and short-term synaptic plasticity: a model of neocortical chattering neurons. Neuroscience. 89 [PubMed]

Waters J, Helmchen F. (2004). Boosting of action potential backpropagation by neocortical network activity in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Waxman SG. (1995). Voltage-gated ion channels in axons: localization, function, and development The Axon. Structure, Function and Pathophysiology.

Wei DS et al. (2001). Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons. Science (New York, N.Y.). 293 [PubMed]

Zhang Y et al. (2002). Identification of genes expressed in C. elegans touch receptor neurons. Nature. 418 [PubMed]

References and models that cite this paper

Anderson RW, Farokhniaee A, Gunalan K, Howell B, McIntyre CC. (2018). Action potential initiation, propagation, and cortical invasion in the hyperdirect pathway during subthalamic deep brain stimulation Brain Stimulation.

Brette R. (2013). Sharpness of spike initiation in neurons explained by compartmentalization. PLoS computational biology. 9 [PubMed]

Casale AE, McCormick DA. (2011). Active action potential propagation but not initiation in thalamic interneuron dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Günay C, Edgerton JR, Jaeger D. (2008). Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Hu W et al. (2009). Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nature neuroscience. 12 [PubMed]

Ju H, Hines ML, Yu Y. (2016). Cable energy function of cortical axons. Scientific reports. 6 [PubMed]

Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N. (2015). Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. eLife. 4 [PubMed]

Kole MH et al. (2008). Action potential generation requires a high sodium channel density in the axon initial segment. Nature neuroscience. 11 [PubMed]

Köndgen H et al. (2008). The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro. Cerebral cortex (New York, N.Y. : 1991). 18 [PubMed]

McCormick DA, Shu Y, Yu Y. (2007). Neurophysiology: Hodgkin and Huxley model--still standing? Nature. 445 [PubMed]

Meeks JP, Mennerick S. (2007). Action potential initiation and propagation in CA3 pyramidal axons. Journal of neurophysiology. 97 [PubMed]

Munro E, Kopell N. (2012). Subthreshold somatic voltage in neocortical pyramidal cells can control whether spikes propagate from the axonal plexus to axon terminals: a model study. Journal of neurophysiology. 107 [PubMed]

Royeck M et al. (2008). Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of neurophysiology. 100 [PubMed]

Shu Y, Yu Y, Yang J, McCormick DA. (2007). Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Yu Y, Shu Y, McCormick DA. (2008). Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Öz P, Huang M, Wolf F. (2015). Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment. Journal of computational neuroscience. 39 [PubMed]

Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA. (2006). Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature. 441 [PubMed]

See more from authors: Shu Y · Hasenstaub A · Duque A · Yu Y · McCormick DA

References and models cited by this paper

Alle H, Geiger JR. (2006). Combined analog and action potential coding in hippocampal mossy fibers. Science (New York, N.Y.). 311 [PubMed]

Awatramani GB, Price GD, Trussell LO. (2005). Modulation of transmitter release by presynaptic resting potential and background calcium levels. Neuron. 48 [PubMed]

Binzegger T, Douglas RJ, Martin KA. (2004). A quantitative map of the circuit of cat primary visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Binzegger T, Douglas RJ, Martin KA. (2005). Axons in cat visual cortex are topologically self-similar. Cerebral cortex (New York, N.Y. : 1991). 15 [PubMed]

Carandini M, Ferster D. (1997). A tonic hyperpolarization underlying contrast adaptation in cat visual cortex. Science (New York, N.Y.). 276 [PubMed]

Cox CL, Denk W, Tank DW, Svoboda K. (2000). Action potentials reliably invade axonal arbors of rat neocortical neurons. Proceedings of the National Academy of Sciences of the United States of America. 97 [PubMed]

Debanne D, Guérineau NC, Gähwiler BH, Thompson SM. (1997). Action-potential propagation gated by an axonal I(A)-like K+ conductance in hippocampus. Nature. 389 [PubMed]

Dorval AD, Christini DJ, White JA. (2001). Real-Time linux dynamic clamp: a fast and flexible way to construct virtual ion channels in living cells. Annals of biomedical engineering. 29 [PubMed]

Fricker D, Verheugen JA, Miles R. (1999). Cell-attached measurements of the firing threshold of rat hippocampal neurones. The Journal of physiology. 517 ( Pt 3) [PubMed]

Geiger JR, Jonas P. (2000). Dynamic control of presynaptic Ca(2+) inflow by fast-inactivating K(+) channels in hippocampal mossy fiber boutons. Neuron. 28 [PubMed]

Gilbert CD, Wiesel TN. (1983). Clustered intrinsic connections in cat visual cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 3 [PubMed]

Hasenstaub A et al. (2005). Inhibitory postsynaptic potentials carry synchronized frequency information in active cortical networks. Neuron. 47 [PubMed]

Ivanov AI, Calabrese RL. (2003). Modulation of spike-mediated synaptic transmission by presynaptic background Ca2+ in leech heart interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Jackson MB, Konnerth A, Augustine GJ. (1991). Action potential broadening and frequency-dependent facilitation of calcium signals in pituitary nerve terminals. Proceedings of the National Academy of Sciences of the United States of America. 88 [PubMed]

Kandel ER, Castellucci VF, Shapiro E. (1980). Presynaptic membrane potential affects transmitter release in an identified neuron in Aplysia by modulating the Ca2+ and K+ currents. Proc Natl Acad Sci U S A. 77

Koester HJ, Sakmann B. (2000). Calcium dynamics associated with action potentials in single nerve terminals of pyramidal cells in layer 2/3 of the young rat neocortex. The Journal of physiology. 529 Pt 3 [PubMed]

Mainen ZF, Joerges J, Huguenard JR, Sejnowski TJ. (1995). A model of spike initiation in neocortical pyramidal neurons. Neuron. 15 [PubMed]

Markram H, Lübke J, Frotscher M, Roth A, Sakmann B. (1997). Physiology and anatomy of synaptic connections between thick tufted pyramidal neurones in the developing rat neocortex. The Journal of physiology. 500 ( Pt 2) [PubMed]

McCormick DA. (1992). Neurotransmitter actions in the thalamus and cerebral cortex and their role in neuromodulation of thalamocortical activity. Progress in neurobiology. 39 [PubMed]

Nicholls J, Wallace BG. (1978). Quantal analysis of transmitter release at an inhibitory synapse in the central nervous system of the leech. The Journal of physiology. 281 [PubMed]

Peters A, Jones EG. (1984). Cerebral Cortex. 1

Sanchez-Vives MV, McCormick DA. (2000). Cellular and network mechanisms of rhythmic recurrent activity in neocortex. Nature neuroscience. 3 [PubMed]

Sanchez-Vives MV, Nowak LG, McCormick DA. (2000). Membrane mechanisms underlying contrast adaptation in cat area 17 in vivo. The Journal of neuroscience : the official journal of the Society for Neuroscience. 20 [PubMed]

Shimahara T, Tauc L. (1975). Multiple interneuronal afferents to the giant cells in Aplysia. The Journal of physiology. 247 [PubMed]

Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA. (2003). Barrages of synaptic activity control the gain and sensitivity of cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Shu Y, Hasenstaub A, McCormick DA. (2003). Turning on and off recurrent balanced cortical activity. Nature. 423 [PubMed]

Steriade M, Nuñez A, Amzica F. (1993). A novel slow (< 1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components. The Journal of neuroscience : the official journal of the Society for Neuroscience. 13 [PubMed]

Steriade M, Timofeev I, Grenier F. (2001). Natural waking and sleep states: a view from inside neocortical neurons. Journal of neurophysiology. 85 [PubMed]

Storm JF. (1988). Temporal integration by a slowly inactivating K+ current in hippocampal neurons. Nature. 336 [PubMed]

Stuart G, Schiller J, Sakmann B. (1997). Action potential initiation and propagation in rat neocortical pyramidal neurons. The Journal of physiology. 505 ( Pt 3) [PubMed]

Welch KM. (2003). Contemporary concepts of migraine pathogenesis. Neurology. 61 [PubMed]

References and models that cite this paper

Brette R et al. (2008). High-resolution intracellular recordings using a real-time computational model of the electrode. Neuron. 59 [PubMed]

Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA. (2011). Somatic membrane potential and Kv1 channels control spike repolarization in cortical axon collaterals and presynaptic boutons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Foutz TJ, Arlow RL, McIntyre CC. (2012). Theoretical principles underlying optical stimulation of a channelrhodopsin-2 positive pyramidal neuron. Journal of neurophysiology. 107 [PubMed]

Grossman N et al. (2013). The spatial pattern of light determines the kinetics and modulates backpropagation of optogenetic action potentials. Journal of computational neuroscience. 34 [PubMed]

Hallermann S, de Kock CP, Stuart GJ, Kole MH. (2012). State and location dependence of action potential metabolic cost in cortical pyramidal neurons. Nature neuroscience. 15 [PubMed]

Hu W et al. (2009). Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nature neuroscience. 12 [PubMed]

Ju H, Hines ML, Yu Y. (2016). Cable energy function of cortical axons. Scientific reports. 6 [PubMed]

Köndgen H et al. (2008). The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro. Cerebral cortex (New York, N.Y. : 1991). 18 [PubMed]

McCormick DA, Shu Y, Yu Y. (2007). Neurophysiology: Hodgkin and Huxley model--still standing? Nature. 445 [PubMed]

Meeks JP, Mennerick S. (2007). Action potential initiation and propagation in CA3 pyramidal axons. Journal of neurophysiology. 97 [PubMed]

Munro E, Kopell N. (2012). Subthreshold somatic voltage in neocortical pyramidal cells can control whether spikes propagate from the axonal plexus to axon terminals: a model study. Journal of neurophysiology. 107 [PubMed]

Schmidt-Hieber C, Bischofberger J. (2010). Fast sodium channel gating supports localized and efficient axonal action potential initiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Schmidt-Hieber C, Jonas P, Bischofberger J. (2007). Subthreshold dendritic signal processing and coincidence detection in dentate gyrus granule cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA. (2007). Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of neurophysiology. 97 [PubMed]

Shu Y, Yu Y, Yang J, McCormick DA. (2007). Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Yu Y, Shu Y, McCormick DA. (2008). Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.