McCormick DA, Shu Y, Yu Y. (2007). Neurophysiology: Hodgkin and Huxley model--still standing? Nature. 445 [PubMed]

See more from authors: McCormick DA · Shu Y · Yu Y

References and models cited by this paper

Baranauskas G, Martina M. (2006). Sodium currents activate without a Hodgkin-and-Huxley-type delay in central mammalian neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

COOMBS JS, CURTIS DR, ECCLES JC. (1957). The generation of impulses in motoneurones. The Journal of physiology. 139 [PubMed]

Colbert CM, Johnston D. (1996). Axonal action-potential initiation and Na+ channel densities in the soma and axon initial segment of subicular pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Colbert CM, Pan E. (2002). Ion channel properties underlying axonal action potential initiation in pyramidal neurons. Nature neuroscience. 5 [PubMed]

Inda MC, DeFelipe J, Muñoz A. (2006). Voltage-gated ion channels in the axon initial segment of human cortical pyramidal cells and their relationship with chandelier cells. Proceedings of the National Academy of Sciences of the United States of America. 103 [PubMed]

Komada M, Soriano P. (2002). [Beta]IV-spectrin regulates sodium channel clustering through ankyrin-G at axon initial segments and nodes of Ranvier. The Journal of cell biology. 156 [PubMed]

Mainen ZF, Sejnowski TJ. (1996). Influence of dendritic structure on firing pattern in model neocortical neurons. Nature. 382 [PubMed]

Naundorf B, Wolf F, Volgushev M. (2006). Unique features of action potential initiation in cortical neurons. Nature. 440 [PubMed]

Palmer LM, Stuart GJ. (2006). Site of action potential initiation in layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Paré D, Shink E, Gaudreau H, Destexhe A, Lang EJ. (1998). Impact of spontaneous synaptic activity on the resting properties of cat neocortical pyramidal neurons In vivo. Journal of neurophysiology. 79 [PubMed]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA. (2007). Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of neurophysiology. 97 [PubMed]

Shu Y, Hasenstaub A, Badoual M, Bal T, McCormick DA. (2003). Barrages of synaptic activity control the gain and sensitivity of cortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Shu Y, Hasenstaub A, Duque A, Yu Y, McCormick DA. (2006). Modulation of intracortical synaptic potentials by presynaptic somatic membrane potential. Nature. 441 [PubMed]

Stuart G, Schiller J, Sakmann B. (1997). Action potential initiation and propagation in rat neocortical pyramidal neurons. The Journal of physiology. 505 ( Pt 3) [PubMed]

References and models that cite this paper

Badel L et al. (2008). Dynamic I-V curves are reliable predictors of naturalistic pyramidal-neuron voltage traces. Journal of neurophysiology. 99 [PubMed]

Brette R. (2013). Sharpness of spike initiation in neurons explained by compartmentalization. PLoS computational biology. 9 [PubMed]

Guo T et al. (2016). Electrical activity of ON and OFF retinal ganglion cells: a modelling study. Journal of neural engineering. 13 [PubMed]

Günay C, Edgerton JR, Jaeger D. (2008). Channel density distributions explain spiking variability in the globus pallidus: a combined physiology and computer simulation database approach. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Hendrickson EB, Edgerton JR, Jaeger D. (2011). The capabilities and limitations of conductance-based compartmental neuron models with reduced branched or unbranched morphologies and active dendrites. Journal of computational neuroscience. 30 [PubMed]

Hendrickson EB, Edgerton JR, Jaeger D. (2011). The use of automated parameter searches to improve ion channel kinetics for neural modeling. Journal of computational neuroscience. 31 [PubMed]

Hu W et al. (2009). Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nature neuroscience. 12 [PubMed]

Ju H, Hines ML, Yu Y. (2016). Cable energy function of cortical axons. Scientific reports. 6 [PubMed]

Köndgen H et al. (2008). The dynamical response properties of neocortical neurons to temporally modulated noisy inputs in vitro. Cerebral cortex (New York, N.Y. : 1991). 18 [PubMed]

López-Jury L, Meza RC, Brown MTC, Henny P, Canavier CC. (2018). Morphological and Biophysical Determinants of the Intracellular and Extracellular Waveforms in Nigral Dopaminergic Neurons: A Computational Study. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

Mercer JN, Chan CS, Tkatch T, Held J, Surmeier DJ. (2007). Nav1.6 sodium channels are critical to pacemaking and fast spiking in globus pallidus neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Platkiewicz J, Brette R. (2010). A threshold equation for action potential initiation. PLoS computational biology. 6 [PubMed]

Platkiewicz J, Brette R. (2011). Impact of fast sodium channel inactivation on spike threshold dynamics and synaptic integration. PLoS computational biology. 7 [PubMed]

Royeck M et al. (2008). Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of neurophysiology. 100 [PubMed]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA. (2007). Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of neurophysiology. 97 [PubMed]

Shu Y, Yu Y, Yang J, McCormick DA. (2007). Selective control of cortical axonal spikes by a slowly inactivating K+ current. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Telenczuk M, Fontaine B, Brette R. (2017). The basis of sharp spike onset in standard biophysical models. PloS one. 12 [PubMed]

Teleńczuk M, Brette R, Destexhe A, Teleńczuk B. (2018). Contribution of the Axon Initial Segment to Action Potentials Recorded Extracellularly. eNeuro. 5 [PubMed]

Yu Y, Shu Y, McCormick DA. (2008). Cortical action potential backpropagation explains spike threshold variability and rapid-onset kinetics. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Zemel BM et al. (2021). Resurgent Na+ currents promote ultrafast spiking in projection neurons that drive fine motor control Nature communications. 12 [PubMed]

Öz P, Huang M, Wolf F. (2015). Action potential initiation in a multi-compartmental model with cooperatively gating Na channels in the axon initial segment. Journal of computational neuroscience. 39 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.