Na channel mutations in the dentate gyrus (Thomas et al. 2009)


Thomas EA, Reid CA, Petrou S. (2010). Mossy fiber sprouting interacts with sodium channel mutations to increase dentate gyrus excitability. Epilepsia. 51 [PubMed]

See more from authors: Thomas EA · Reid CA · Petrou S

References and models cited by this paper

Babb TL, Kupfer WR, Pretorius JK, Crandall PH, Levesque MF. (1991). Synaptic reorganization by mossy fibers in human epileptic fascia dentata. Neuroscience. 42 [PubMed]

Chiu C et al. (2008). Developmental impact of a familial GABAA receptor epilepsy mutation. Annals of neurology. 64 [PubMed]

Dudek FE, Sutula TP. (2007). Epileptogenesis in the dentate gyrus: a critical perspective. Progress in brain research. 163 [PubMed]

Dyhrfjeld-Johnsen J et al. (2007). Topological determinants of epileptogenesis in large-scale structural and functional models of the dentate gyrus derived from experimental data. Journal of neurophysiology. 97 [PubMed]

Fellous JM, Rudolph M, Destexhe A, Sejnowski TJ. (2003). Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in vivo activity. Neuroscience. 122 [PubMed]

Heinemann U et al. (1992). The dentate gyrus as a regulated gate for the propagation of epileptiform activity. Epilepsy research. Supplement. 7 [PubMed]

Hines M. (1984). Efficient computation of branched nerve equations. International journal of bio-medical computing. 15 [PubMed]

Houser CR et al. (1990). Altered patterns of dynorphin immunoreactivity suggest mossy fiber reorganization in human hippocampal epilepsy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 10 [PubMed]

Howard AL, Neu A, Morgan RJ, Echegoyen JC, Soltesz I. (2007). Opposing modifications in intrinsic currents and synaptic inputs in post-traumatic mossy cells: evidence for single-cell homeostasis in a hyperexcitable network. Journal of neurophysiology. 97 [PubMed]

Kananura C et al. (2002). A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions. Archives of neurology. 59 [PubMed]

Lothman EW, Stringer JL, Bertram EH. (1992). The dentate gyrus as a control point for seizures in the hippocampus and beyond. Epilepsy research. Supplement. 7 [PubMed]

Lytton WW. (2008). Computer modelling of epilepsy. Nature reviews. Neuroscience. 9 [PubMed]

Mascagni MV, Sherman AS. (1998). Numerical methods for neuronal modelling. Methods in Neuronal Modeling From Synapses to Networks, 2nd Edition.

Morgan RJ, Soltesz I. (2008). Nonrandom connectivity of the epileptic dentate gyrus predicts a major role for neuronal hubs in seizures. Proceedings of the National Academy of Sciences of the United States of America. 105 [PubMed]

Ogiwara I et al. (2007). Nav1.1 localizes to axons of parvalbumin-positive inhibitory interneurons: a circuit basis for epileptic seizures in mice carrying an Scn1a gene mutation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Press WH, Teukolsky SA, Vetterling WT, Flannery BP. (1988). Numerical recipes in C: the art of scientific computing.

Reid CA, Berkovic SF, Petrou S. (2009). Mechanisms of human inherited epilepsies. Progress in neurobiology. 87 [PubMed]

Santhakumar V, Aradi I, Soltesz I. (2005). Role of mossy fiber sprouting and mossy cell loss in hyperexcitability: a network model of the dentate gyrus incorporating cell types and axonal topography. Journal of neurophysiology. 93 [PubMed]

Santhakumar V, Ratzliff AD, Jeng J, Toth Z, Soltesz I. (2001). Long-term hyperexcitability in the hippocampus after experimental head trauma. Annals of neurology. 50 [PubMed]

Scheffer IE et al. (2007). Temporal lobe epilepsy and GEFS+ phenotypes associated with SCN1B mutations. Brain : a journal of neurology. 130 [PubMed]

Spampanato J, Aradi I, Soltesz I, Goldin AL. (2004). Increased neuronal firing in computer simulations of sodium channel mutations that cause generalized epilepsy with febrile seizures plus. Journal of neurophysiology. 91 [PubMed]

Spampanato J, Escayg A, Meisler MH, Goldin AL. (2001). Functional effects of two voltage-gated sodium channel mutations that cause generalized epilepsy with febrile seizures plus type 2. The Journal of neuroscience : the official journal of the Society for Neuroscience. 21 [PubMed]

Staley KJ, Otis TS, Mody I. (1992). Membrane properties of dentate gyrus granule cells: comparison of sharp microelectrode and whole-cell recordings. Journal of neurophysiology. 67 [PubMed]

Stringer JL, Lothman EW. (1992). Bilateral maximal dentate activation is critical for the appearance of an afterdischarge in the dentate gyrus. Neuroscience. 46 [PubMed]

Sutula TP, Hermann B. (1999). Progression in mesial temporal lobe epilepsy. Annals of neurology. 45 [PubMed]

Tan HO et al. (2007). Reduced cortical inhibition in a mouse model of familial childhood absence epilepsy. Proceedings of the National Academy of Sciences of the United States of America. 104 [PubMed]

Thomas EA. (2000). A parallel algorithm for simulation of large neural networks. Journal of neuroscience methods. 98 [PubMed]

Thomas EA, Petrou S. (2008). Case for realistic modeling in understanding seizures. Expert review of neurotherapeutics. 8 [PubMed]

Thomas EA, Xu R, Petrou S. (2007). Computational analysis of the R85C and R85H epilepsy mutations in Na+ channel beta1 subunits. Neuroscience. 147 [PubMed]

Wallace RH et al. (2001). Mutant GABA(A) receptor gamma2-subunit in childhood absence epilepsy and febrile seizures. Nature genetics. 28 [PubMed]

Xu R et al. (2007). Generalized epilepsy with febrile seizures plus-associated sodium channel beta1 subunit mutations severely reduce beta subunit-mediated modulation of sodium channel function. Neuroscience. 148 [PubMed]

Yu FH et al. (2006). Reduced sodium current in GABAergic interneurons in a mouse model of severe myoclonic epilepsy in infancy. Nature neuroscience. 9 [PubMed]

de Lanerolle NC, Kim JH, Robbins RJ, Spencer DD. (1989). Hippocampal interneuron loss and plasticity in human temporal lobe epilepsy. Brain research. 495 [PubMed]

References and models that cite this paper

Bezaire MJ, Raikov I, Burk K, Vyas D, Soltesz I. (2016). Interneuronal mechanisms of hippocampal theta oscillations in a full-scale model of the rodent CA1 circuit. eLife. 5 [PubMed]

Gurkiewicz M, Korngreen A, Waxman SG, Lampert A. (2011). Kinetic modeling of Nav1.7 provides insight into erythromelalgia-associated F1449V mutation. Journal of neurophysiology. 105 [PubMed]

Tejada J, Arisi GM, GarcĂ­a-Cairasco N, Roque AC. (2012). Morphological alterations in newly born dentate gyrus granule cells that emerge after status epilepticus contribute to make them less excitable. PloS one. 7 [PubMed]

Thomas EA, Petrou S. (2013). Network-specific mechanisms may explain the paradoxical effects of carbamazepine and phenytoin. Epilepsia. 54 [PubMed]

Thomas EA, Reid CA, Berkovic SF, Petrou S. (2009). Prediction by modeling that epilepsy may be caused by very small functional changes in ion channels. Archives of neurology. 66 [PubMed]

Yim MY, Hanuschkin A, Wolfart J. (2015). Intrinsic rescaling of granule cells restores pattern separation ability of a dentate gyrus network model during epileptic hyperexcitability. Hippocampus. 25 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.