A single kinetic model for all human voltage-gated sodium channels (Balbi et al, 2017)


Balbi P, Massobrio P, Hellgren Kotaleski J. (2017). A single Markov-type kinetic model accounting for the macroscopic currents of all human voltage-gated sodium channel isoforms. PLoS computational biology. 13 [PubMed]

See more from authors: Balbi P · Massobrio P · Hellgren Kotaleski J

References and models cited by this paper

Andavan GS, Lemmens-Gruber R. (2011). Voltage-gated sodium channels: mutations, channelopathies and targets. Current medicinal chemistry. 18 [PubMed]

Armstrong CM. (1981). Sodium channels and gating currents. Physiological reviews. 61 [PubMed]

Arnold WD et al. (2015). Defective fast inactivation recovery of Nav 1.4 in congenital myasthenic syndrome. Annals of neurology. 77 [PubMed]

Balbi P, Martinoia S, Massobrio P. (2015). Axon-somatic back-propagation in detailed models of spinal alpha motoneurons. Frontiers in computational neuroscience. 9 [PubMed]

Bezanilla F. (1985). Gating of sodium and potassium channels. The Journal of membrane biology. 88 [PubMed]

Bezanilla F. (2008). Ion channels: from conductance to structure. Neuron. 60 [PubMed]

Borg-graham L. (1999). Interpretations of data and mechanisms for hippocampal pyramidal cell models Cerebral Cortex cortical Models. 13

Brent R. (1976). A new algorithm for minimizing a function of several variables without calculating derivatives. Algorithms For Minimization Without Derivatives.

Burbidge SA et al. (2002). Molecular cloning, distribution and functional analysis of the NA(V)1.6. Voltage-gated sodium channel from human brain. Brain research. Molecular brain research. 103 [PubMed]

Burzomato V, Beato M, Groot-Kormelink PJ, Colquhoun D, Sivilotti LG. (2004). Single-channel behavior of heteromeric alpha1beta glycine receptors: an attempt to detect a conformational change before the channel opens. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Börjesson SI, Elinder F. (2008). Structure, function, and modification of the voltage sensor in voltage-gated ion channels. Cell biochemistry and biophysics. 52 [PubMed]

Cannon RC, D'Alessandro G. (2006). The ion channel inverse problem: neuroinformatics meets biophysics. PLoS computational biology. 2 [PubMed]

Carr DB et al. (2003). Transmitter modulation of slow, activity-dependent alterations in sodium channel availability endows neurons with a novel form of cellular plasticity. Neuron. 39 [PubMed]

Chatelier A, Dahllund L, Eriksson A, Krupp J, Chahine M. (2008). Biophysical properties of human Na v1.7 splice variants and their regulation by protein kinase A. Journal of neurophysiology. 99 [PubMed]

Chizhov AV, Smirnova EY, Kim KKh, Zaitsev AV. (2014). A simple Markov model of sodium channels with a dynamic threshold. Journal of computational neuroscience. 37 [PubMed]

Churchland PS, Sejnowski TJ. (2016). Blending computational and experimental neuroscience. Nature reviews. Neuroscience. 17 [PubMed]

Clare JJ, Tate SN, Nobbs M, Romanos MA. (2000). Voltage-gated sodium channels as therapeutic targets. Drug discovery today. 5 [PubMed]

Colquhoun D, Dowsland KA, Beato M, Plested AJ. (2004). How to impose microscopic reversibility in complex reaction mechanisms. Biophysical journal. 86 [PubMed]

Colquhoun D, Hawkes AG. (1977). Relaxation and fluctuations of membrane currents that flow through drug-operated channels. Proceedings of the Royal Society of London. Series B, Biological sciences. 199 [PubMed]

Cooley JW, Dodge FA. (1973). Action Potential of the Motorneuron. IBM J Res Dev. 17

Cusdin FS et al. (2010). The sodium channel {beta}3-subunit induces multiphasic gating in NaV1.3 and affects fast inactivation via distinct intracellular regions. The Journal of biological chemistry. 285 [PubMed]

Destexhe A, Huguenard JR. (2001). Which formalism to use for modeling voltage-dependent conductances? Computational Neuroscience.

Destexhe A, Mainen ZF, Sejnowski TJ. (1994). Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism. Journal of computational neuroscience. 1 [PubMed]

Doyle DA et al. (1998). The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (New York, N.Y.). 280 [PubMed]

Epstein M, Calderhead B, Girolami MA, Sivilotti LG. (2016). Bayesian Statistical Inference in Ion-Channel Models with Exact Missed Event Correction. Biophysical journal. 111 [PubMed]

Fleidervish IA, Friedman A, Gutnick MJ. (1996). Slow inactivation of Na+ current and slow cumulative spike adaptation in mouse and guinea-pig neocortical neurones in slices. The Journal of physiology. 493 ( Pt 1) [PubMed]

Gentet LJ, Stuart GJ, Clements JD. (2000). Direct measurement of specific membrane capacitance in neurons. Biophysical journal. 79 [PubMed]

HODGKIN AL, HUXLEY AF. (1952). A quantitative description of membrane current and its application to conduction and excitation in nerve. The Journal of physiology. 117 [PubMed]

Han C et al. (2015). The Domain II S4-S5 Linker in Nav1.9: A Missense Mutation Enhances Activation, Impairs Fast Inactivation, and Produces Human Painful Neuropathy. Neuromolecular medicine. 17 [PubMed]

Hille B. (1992). Ion Channels of Excitable Membranes.

Hines ML, Carnevale NT. (2006). The NEURON Book.

Hu W et al. (2009). Distinct contributions of Na(v)1.6 and Na(v)1.2 in action potential initiation and backpropagation. Nature neuroscience. 12 [PubMed]

Huang J et al. (2013). Small-fiber neuropathy Nav1.8 mutation shifts activation to hyperpolarized potentials and increases excitability of dorsal root ganglion neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]

Izhikevich EM. (2003). Simple model of spiking neurons. IEEE transactions on neural networks. 14 [PubMed]

Karoly R, Lenkey N, Juhasz AO, Vizi ES, Mike A. (2010). Fast- or slow-inactivated state preference of Na+ channel inhibitors: a simulation and experimental study. PLoS computational biology. 6 [PubMed]

Keynes RD, Elinder F. (1998). Modelling the activation, opening, inactivation and reopening of the voltage-gated sodium channel. Proceedings. Biological sciences. 265 [PubMed]

Knight BW. (1972). Dynamics of encoding in a population of neurons. The Journal of general physiology. 59 [PubMed]

Kohn MC. (1989). Computer modeling at the National Biomedical Simulation Resource Computers And Mathematics With Applications. 18

Kozlov AK, Kardamakis AA, Hellgren Kotaleski J, Grillner S. (2014). Gating of steering signals through phasic modulation of reticulospinal neurons during locomotion. Proceedings of the National Academy of Sciences of the United States of America. 111 [PubMed]

Kuo CC, Bean BP. (1994). Na+ channels must deactivate to recover from inactivation. Neuron. 12 [PubMed]

Markram H et al. (2015). Reconstruction and Simulation of Neocortical Microcircuitry. Cell. 163 [PubMed]

Maurice N et al. (2004). D2 dopamine receptor-mediated modulation of voltage-dependent Na+ channels reduces autonomous activity in striatal cholinergic interneurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

McDougal RA et al. (2017). Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience. Journal of computational neuroscience. 42 [PubMed]

Meunier C, Segev I. (2002). Playing the devil's advocate: is the Hodgkin-Huxley model useful? Trends in neurosciences. 25 [PubMed]

Milescu LS, Yamanishi T, Ptak K, Mogri MZ, Smith JC. (2008). Real-time kinetic modeling of voltage-gated ion channels using dynamic clamp. Biophysical journal. 95 [PubMed]

Milescu LS, Yamanishi T, Ptak K, Smith JC. (2010). Kinetic properties and functional dynamics of sodium channels during repetitive spiking in a slow pacemaker neuron. The Journal of neuroscience : the official journal of the Society for Neuroscience. 30 [PubMed]

Misra SN, Kahlig KM, George AL. (2008). Impaired NaV1.2 function and reduced cell surface expression in benign familial neonatal-infantile seizures. Epilepsia. 49 [PubMed]

Neher E, Sakmann B. (1976). Single-channel currents recorded from membrane of denervated frog muscle fibres. Nature. 260 [PubMed]

Patlak J. (1991). Molecular kinetics of voltage-dependent Na+ channels. Physiological reviews. 71 [PubMed]

Raman IM, Bean BP. (2001). Inactivation and recovery of sodium currents in cerebellar Purkinje neurons: evidence for two mechanisms. Biophysical journal. 80 [PubMed]

Rhodes TH, Lossin C, Vanoye CG, Wang DW, George AL. (2004). Noninactivating voltage-gated sodium channels in severe myoclonic epilepsy of infancy. Proceedings of the National Academy of Sciences of the United States of America. 101 [PubMed]

Rybak IA, Shevtsova NA, Lafreniere-Roula M, McCrea DA. (2006). Modelling spinal circuitry involved in locomotor pattern generation: insights from deletions during fictive locomotion. The Journal of physiology. 577 [PubMed]

Sakmann B, Neher E. (1995). Single-channel Recording. 2

Sejnowski TJ, Bush PC. (1991). Simulations of a reconstructed cerebellar Purkinje cell based on simplified channel kinetics Neural Comput. 3

Sivagnanam S et al. (2015). Early experiences in developing and managing the neuroscience gateway. Concurrency and computation : practice & experience. 27 [PubMed]

Southan C et al. (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucleic acids research. 44 [PubMed]

Strassberg AF, Defelice LJ. (1993). Limitations of the Hodgkin-Huxley formalism: eects of single channel kinetics on transmembrane voltage dynamics Neural Comput. 5

Taddese A, Bean BP. (2002). Subthreshold sodium current from rapidly inactivating sodium channels drives spontaneous firing of tuberomammillary neurons. Neuron. 33 [PubMed]

Traub RD et al. (2005). Single-column thalamocortical network model exhibiting gamma oscillations, sleep spindles, and epileptogenic bursts. Journal of neurophysiology. 93 [PubMed]

Vanoye CG, Kunic JD, Ehring GR, George AL. (2013). Mechanism of sodium channel NaV1.9 potentiation by G-protein signaling. The Journal of general physiology. 141 [PubMed]

Zhang Z et al. (2013). Kinetic model of Nav1.5 channel provides a subtle insight into slow inactivation associated excitability in cardiac cells. PloS one. 8 [PubMed]

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.