Model Concept: Epilepsy

Abnormal electrical oscillations of the nervous system which occur with symptoms of convulsions and/or partial or total loss of consciousness.

  1. A bistable model of Spike-Wave seizure and background activity (Taylor et al. 2014)
  2. A cortical sheet mesoscopic model for investigating focal seizure onset dynamics (Wang et al. 2014)
  3. A focal seizure model with ion concentration changes (Gentiletti et al., 2022)
  4. A model for focal seizure onset, propagation, evolution, and progression (Liou et al 2020)
  5. A multilayer cortical model to study seizure propagation across microdomains (Basu et al. 2015)
  6. A NN with synaptic depression for testing the effects of connectivity on dynamics (Jacob et al 2019)
  7. A single column thalamocortical network model (Traub et al 2005)
  8. A spatially extended model for macroscopic spike-wave discharges (Taylor and Baier 2011)
  9. Basal ganglia-corticothalamic (BGCT) network (Chen et al., 2014)
  10. CA1 pyramidal cell: reconstructed axonal arbor and failures at weak gap junctions (Vladimirov 2011)
  11. CA1 pyramidal neuron to study INaP properties and repetitive firing (Uebachs et al. 2010)
  12. CA1 pyramidal neuron: effects of R213Q and R312W Kv7.2 mutations (Miceli et al. 2013)
  13. CA1 pyramidal neuron: h channel-dependent deficit of theta oscill. resonance (Marcelin et al. 2008)
  14. CA1 pyramidal neuron: Ih current (Migliore et al. 2012)
  15. CA3 Network Model of Epileptic Activity (Sanjay et. al, 2015)
  16. Changes of ionic concentrations during seizure transitions (Gentiletti et al. 2016)
  17. Collection of simulated data from a thalamocortical network model (Glabska, Chintaluri, Wojcik 2017)
  18. Complex CA1-neuron to study AP initiation (Wimmer et al. 2010)
  19. Computational neuropharmacology of CA1 pyramidal neuron (Ferrante et al. 2008)
  20. Computational Surgery (Lytton et al. 2011)
  21. Computer model of clonazepam's effect in thalamic slice (Lytton 1997)
  22. Computer simulations of neuron-glia interactions mediated by ion flux (Somjen et al. 2008)
  23. Contribution of ATP-sensitive potassium channels in the neuronal network (Huang et al. 2009)
  24. Cortical network model of posttraumatic epileptogenesis (Bush et al 1999)
  25. Dentate gyrus (Morgan et al. 2007, 2008, Santhakumar et al. 2005, Dyhrfjeld-Johnsen et al. 2007)
  26. Dentate gyrus network model (Santhakumar et al 2005)
  27. Dentate gyrus network model (Tejada et al 2014)
  28. Dentate gyrus network model pattern separation and granule cell scaling in epilepsy (Yim et al 2015)
  29. Dependence of neuronal firing on astroglial membrane transport mechanisms (Oyehaug et al 2012)
  30. Early-onset epileptic encephalopathy (Miceli et al. 2015)
  31. Electrodecrements in in vitro model of infantile spasms (Traub et al 2020)
  32. Epilepsy may be caused by very small functional changes in ion channels (Thomas et al. 2009)
  33. Epileptic seizure model with Morris-Lecar neurons (Beverlin and Netoff 2011)
  34. Febrile seizure-induced modifications to Ih (Chen et al 2001)
  35. Healthy and Epileptic Hippocampal Circuit (Aussel et al 2022)
  36. Hippocampal CA3 network and circadian regulation (Stanley et al. 2013)
  37. Human seizures couple across spatial scales through travelling wave dynamics (Martinet et al 2017)
  38. Inhibition and glial-K+ interaction leads to diverse seizure transition modes (Ho & Truccolo 2016)
  39. Inhibitory network bistability explains increased activity prior to seizure onset (Rich et al 2020)
  40. JitCon: Just in time connectivity for large spiking networks (Lytton et al. 2008)
  41. Kinetic properties of voltage gated Na channel (Nayak and Sikdar 2007)
  42. Macroscopic model of epilepsy (Fietkiewicz & Loparo 2016)
  43. Markov models of SCN1A (NaV1.1) applied to abnormal gating and epilepsy (Clancy and Kass 2004)
  44. Mechanisms of very fast oscillations in axon networks coupled by gap junctions (Munro, Borgers 2010)
  45. Mechanisms underlying different onset patterns of focal seizures (Wang Y et al 2017)
  46. Minimal model of interictal and ictal discharges “Epileptor-2” (Chizhov et al 2018)
  47. Modeling epileptic seizure induced by depolarization block (Kim & Dykamp 2017)
  48. Multiscale modeling of epileptic seizures (Naze et al. 2015)
  49. Na channel mutations in the dentate gyrus (Thomas et al. 2009)
  50. Neocort. pyramidal cells subthreshold somatic voltage controls spike propagation (Munro Kopell 2012)
  51. Network model with dynamic ion concentrations (Ullah et al. 2009)
  52. Network model with neocortical architecture (Anderson et al 2007,2012; Azhar et al 2012)
  53. Neural-field model of generalized seizures (Zhao et al., 2015)
  54. Neuronal population models of intracerebral EEG (Wendling et al. 2005)
  55. Normal ripples, abnormal ripples, and fast ripples in a hippocampal model (Fink et al. 2015)
  56. Paradoxical GABA-mediated excitation (Lewin et al. 2012)
  57. Periodicity in Na channel properties alters model neuron excitability (Majumdar and Sikdar 2007)
  58. Persistent synchronized bursting activity in cortical tissues (Golomb et al 2005)
  59. PyPNS: Multiscale Simulation of a Peripheral Nerve in Python (Lubba et al 2018)
  60. Pyramidal neurons with mutated SCN2A gene (Nav1.2) (Ben-Shalom et al 2017)
  61. Role for short term plasticity and OLM cells in containing spread of excitation (Hummos et al 2014)
  62. SCN1A gain-of-function in early infantile encephalopathy (Berecki et al 2019)
  63. Small world networks of Type I and Type II Excitable Neurons (Bogaard et al. 2009)
  64. Sodium channel mutations causing generalized epilepsy with febrile seizures + (Barela et al. 2006)
  65. State dependent drug binding to sodium channels in the dentate gyrus (Thomas & Petrou 2013)
  66. Status epilepticus alters dentate basket cell tonic inhibition (Yu J et al 2013)
  67. Studies of stimulus parameters for seizure disruption using NN simulations (Anderson et al. 2007)
  68. Subiculum network model with dynamic chloride/potassium homeostasis (Buchin et al 2016)
  69. T channel currents (Vitko et al 2005)
  70. Thalamocortical model of spike and wave seizures (Suffczynski et al. 2004)
  71. The origin of different spike and wave-like events (Hall et al 2017)
  72. The role of ATP-sensitive potassium channels in a hippocampal neuron (Huang et al. 2007)
  73. The Virtual Mouse Brain (TVMB) (Melozzi et al. 2017)
  74. Tonic-clonic transitions in a seizure simulation (Lytton and Omurtag 2007)
  75. Two-neuron conductance-based model with dynamic ion concentrations to study NaV1.1 channel mutations
  76. Unbalanced peptidergic inhibition in superficial cortex underlies seizure activity (Hall et al 2015)
  77. Zonisamide-induced inhibition of the firing of APs in hippocampal neurons (Huang et al. 2007)
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