CA1 pyramidal neuron: as a 2-layer NN and subthreshold synaptic summation (Poirazi et al 2003)


Poirazi P, Brannon T, Mel BW. (2003). Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron. 37 [PubMed]

See more from authors: Poirazi P · Brannon T · Mel BW

References and models cited by this paper

Archie KA, Mel BW. (2000). A model for intradendritic computation of binocular disparity. Nature neuroscience. 3 [PubMed]

Bernander O, Koch C, Douglas RJ. (1994). Amplification and linearization of distal synaptic input to cortical pyramidal cells. Journal of neurophysiology. 72 [PubMed]

Bishop C. (1995). Neural Networks For Pattern Recognition.

Cannon RC, Turner DA, Pyapali GK, Wheal HV. (1998). An on-line archive of reconstructed hippocampal neurons. Journal of neuroscience methods. 84 [PubMed]

Cash S, Yuste R. (1998). Input summation by cultured pyramidal neurons is linear and position-independent. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Cash S, Yuste R. (1999). Linear summation of excitatory inputs by CA1 pyramidal neurons. Neuron. 22 [PubMed]

Cauller LJ, Connors BW. (1992). Functions of very distal dendrites: experimental and computational studies of layer I synapses on neocortical pyramidal cells. Single Neuron Computation.

De Schutter E, Bower JM. (1994). Simulated responses of cerebellar Purkinje cells are independent of the dendritic location of granule cell synaptic inputs. Proceedings of the National Academy of Sciences of the United States of America. 91 [PubMed]

Gillessen T, Alzheimer C. (1997). Amplification of EPSPs by low Ni(2+)- and amiloride-sensitive Ca2+ channels in apical dendrites of rat CA1 pyramidal neurons. Journal of neurophysiology. 77 [PubMed]

Golding NL, Jung HY, Mickus T, Spruston N. (1999). Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Golding NL, Spruston N. (1998). Dendritic sodium spikes are variable triggers of axonal action potentials in hippocampal CA1 pyramidal neurons. Neuron. 21 [PubMed]

González-Burgos G, Barrionuevo G. (2001). Voltage-gated sodium channels shape subthreshold EPSPs in layer 5 pyramidal neurons from rat prefrontal cortex. Journal of neurophysiology. 86 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hoffman DA, Magee JC, Colbert CM, Johnston D. (1997). K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature. 387 [PubMed]

Häusser M, Spruston N, Stuart GJ. (2000). Diversity and dynamics of dendritic signaling. Science (New York, N.Y.). 290 [PubMed]

Koch C, Poggio T, Torre V. (1983). Nonlinear interactions in a dendritic tree: localization, timing, and role in information processing. Proceedings of the National Academy of Sciences of the United States of America. 80 [PubMed]

Lipowsky R, Gillessen T, Alzheimer C. (1996). Dendritic Na+ channels amplify EPSPs in hippocampal CA1 pyramidal cells. Journal of neurophysiology. 76 [PubMed]

Magee J, Hoffman D, Colbert C, Johnston D. (1998). Electrical and calcium signaling in dendrites of hippocampal pyramidal neurons. Annual review of physiology. 60 [PubMed]

Magee JC. (2000). Dendritic integration of excitatory synaptic input. Nature reviews. Neuroscience. 1 [PubMed]

Magee JC, Cook EP. (2000). Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature neuroscience. 3 [PubMed]

Margulis M, Tang CM. (1998). Temporal integration can readily switch between sublinear and supralinear summation. Journal of neurophysiology. 79 [PubMed]

Mel BW. (1992). NMDA-based pattern discrimination in a modeled cortical neuron. Neural Comput. 4

Mel BW. (1992). The clusteron: toward a simple abstraction for a complex neuron Advances in Neural Information Processing Systems 11. 4

Mel BW. (1993). Synaptic integration in an excitable dendritic tree. Journal of neurophysiology. 70 [PubMed]

Mel BW. (1999). Why have dendrites? A computational perspective. Dendrites. Stuart G, Spruston N, and Hausser M eds..

Mel BW, Ruderman DL, Archie KA. (1998). Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Nettleton JS, Spain WJ. (2000). Linear to supralinear summation of AMPA-mediated EPSPs in neocortical pyramidal neurons. Journal of neurophysiology. 83 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Pyramidal neuron as two-layer neural network. Neuron. 37 [PubMed]

Poirazi P, Mel BW. (2001). Impact of active dendrites and structural plasticity on the memory capacity of neural tissue. Neuron. 29 [PubMed]

Reyes A. (2001). Influence of dendritic conductances on the input-output properties of neurons. Annual review of neuroscience. 24 [PubMed]

Sakmann B, Reyes AD. (1996). Summation of synaptic potentials in layer V pyramidal neurons Soc Neurosci Abstr. 22

Schiller J, Major G, Koester HJ, Schiller Y. (2000). NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature. 404 [PubMed]

Schwindt PC, Crill WE. (1998). Synaptically evoked dendritic action potentials in rat neocortical pyramidal neurons. Journal of neurophysiology. 79 [PubMed]

Segev I, Rall W. (1987). Functional possibilities for synapses on dendrites and on dendritic spines. Synaptic Function. Edelman G, Gall W, and Cowan W eds..

Shepherd GM, Brayton RK. (1987). Logic operations are properties of computer-simulated interactions between excitable dendritic spines. Neuroscience. 21 [PubMed]

Skydsgaard M, Hounsgaard J. (1994). Spatial integration of local transmitter responses in motoneurones of the turtle spinal cord in vitro. The Journal of physiology. 479 ( Pt 2) [PubMed]

Spruston N, Hausser M, Stuart G. (1999). Dendrites..

Urban NN, Barrionuevo G. (1998). Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 95 [PubMed]

Urban NN, Henze DA, Barrionuevo G. (1998). Amplification of perforant-path EPSPs in CA3 pyramidal cells by LVA calcium and sodium channels. Journal of neurophysiology. 80 [PubMed]

Wei DS et al. (2001). Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons. Science (New York, N.Y.). 293 [PubMed]

Wessel R, Kristan WB, Kleinfeld D. (1999). Supralinear summation of synaptic inputs by an invertebrate neuron: dendritic gain is mediated by an "inward rectifier" K(+) current. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Yuste R, Tsay D, Holthoff K. (2000). Synaptic stimulation elicits local spikes in dendrites of mouse layer 5 pyramidal neurons Soc Neurosci Abstr. 1

References and models that cite this paper

Arsiero M, Lüscher HR, Lundstrom BN, Giugliano M. (2007). The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Bahl A, Stemmler MB, Herz AV, Roth A. (2012). Automated optimization of a reduced layer 5 pyramidal cell model based on experimental data. Journal of neuroscience methods. 210 [PubMed]

Behabadi BF, Mel BW. (2014). Mechanisms underlying subunit independence in pyramidal neuron dendrites. Proceedings of the National Academy of Sciences of the United States of America. 111 [PubMed]

Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW. (2012). Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites. PLoS computational biology. 8 [PubMed]

Bianchi D et al. (2012). On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons. Journal of computational neuroscience. 33 [PubMed]

Bock T, Negrean A, Siegelbaum SA. (2022). Somatic depolarization enhances hippocampal CA1 dendritic spike propagation and distal input-driven synaptic plasticity The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 [PubMed]

Cannon RC, O'Donnell C, Nolan MF. (2010). Stochastic ion channel gating in dendritic neurons: morphology dependence and probabilistic synaptic activation of dendritic spikes. PLoS computational biology. 6 [PubMed]

Cutsuridis V, Cobb S, Graham BP. (2010). Encoding and retrieval in a model of the hippocampal CA1 microcircuit. Hippocampus. 20 [PubMed]

Cutsuridis V, Poirazi P. (2015). A computational study on how theta modulated inhibition can account for the long temporal windows in the entorhinal-hippocampal loop. Neurobiology of learning and memory. 120 [PubMed]

Doron M, Chindemi G, Muller E, Markram H, Segev I. (2017). Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons. Cell reports. 21 [PubMed]

Du K et al. (2017). Cell-type-specific inhibition of the dendritic plateau potential in striatal spiny projection neurons. Proceedings of the National Academy of Sciences of the United States of America. 114 [PubMed]

Eyal G et al. (2018). Human Cortical Pyramidal Neurons: From Spines to Spikes via Models. Frontiers in cellular neuroscience. 12 [PubMed]

Friedrich P, Vella M, Gulyás AI, Freund TF, Káli S. (2014). A flexible, interactive software tool for fitting the parameters of neuronal models. Frontiers in neuroinformatics. 8 [PubMed]

Gleeson P et al. (2010). NeuroML: a language for describing data driven models of neurons and networks with a high degree of biological detail. PLoS computational biology. 6 [PubMed]

Gold C, Henze DA, Koch C, Buzsáki G. (2006). On the origin of the extracellular action potential waveform: A modeling study. Journal of neurophysiology. 95 [PubMed]

Graham BP, Saudargiene A, Cobb S. (2014). Spine head calcium as a measure of summed postsynaptic activity for driving synaptic plasticity. Neural computation. 26 [PubMed]

Graupner M, Brunel N. (2007). STDP in a bistable synapse model based on CaMKII and associated signaling pathways. PLoS computational biology. 3 [PubMed]

Groen MR et al. (2014). Development of dendritic tonic GABAergic inhibition regulates excitability and plasticity in CA1 pyramidal neurons. Journal of neurophysiology. 112 [PubMed]

Gómez González JF, Mel BW, Poirazi P. (2011). Distinguishing Linear vs. Non-Linear Integration in CA1 Radial Oblique Dendrites: It's about Time. Frontiers in computational neuroscience. 5 [PubMed]

Hao J, Wang XD, Dan Y, Poo MM, Zhang XH. (2009). An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Hasselmo ME, Eichenbaum H. (2005). Hippocampal mechanisms for the context-dependent retrieval of episodes. Neural networks : the official journal of the International Neural Network Society. 18 [PubMed]

Hay E, Hill S, Schürmann F, Markram H, Segev I. (2011). Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS computational biology. 7 [PubMed]

Holmes WR, Ambros-Ingerson J, Grover LM. (2006). Fitting experimental data to models that use morphological data from public databases. Journal of computational neuroscience. 20 [PubMed]

Holmes WR, Grover LM. (2006). Quantifying the magnitude of changes in synaptic level parameters with long-term potentiation. Journal of neurophysiology. 96 [PubMed]

Huys QJ, Ahrens MB, Paninski L. (2006). Efficient estimation of detailed single-neuron models. Journal of neurophysiology. 96 [PubMed]

Huys QJ, Paninski L. (2009). Smoothing of, and parameter estimation from, noisy biophysical recordings. PLoS computational biology. 5 [PubMed]

Huys QJ, Zemel RS, Natarajan R, Dayan P. (2007). Fast population coding. Neural computation. 19 [PubMed]

Häusser M, Mel B. (2003). Dendrites: bug or feature? Current opinion in neurobiology. 13 [PubMed]

Jarsky T, Roxin A, Kath WL, Spruston N. (2005). Conditional dendritic spike propagation following distal synaptic activation of hippocampal CA1 pyramidal neurons. Nature neuroscience. 8 [PubMed]

Joels M, Poirazi P, Sidiropoulou K. (2007). Modeling stress-induced adaptations in Ca2+ dynamics Neurocomputing. 70

Kastellakis G, Silva AJ, Poirazi P. (2016). Linking Memories across Time via Neuronal and Dendritic Overlaps in Model Neurons with Active Dendrites. Cell reports. 17 [PubMed]

Kim Y, Hsu CL, Cembrowski MS, Mensh BD, Spruston N. (2015). Dendritic sodium spikes are required for long-term potentiation at distal synapses on hippocampal pyramidal neurons. eLife. 4 [PubMed]

Le Franc Y, Le Masson G. (2010). Multiple firing patterns in deep dorsal horn neurons of the spinal cord: computational analysis of mechanisms and functional implications. Journal of neurophysiology. 104 [PubMed]

Lewin N, Aksay E, Clancy CE. (2012). Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. PloS one. 7 [PubMed]

Li X, Ascoli GA. (2006). Computational simulation of the input-output relationship in hippocampal pyramidal cells. Journal of computational neuroscience. 21 [PubMed]

Li X, Ascoli GA. (2008). Effects of synaptic synchrony on the neuronal input-output relationship. Neural computation. 20 [PubMed]

Liebmann L et al. (2008). Differential effects of corticosterone on the slow afterhyperpolarization in the basolateral amygdala and CA1 region: possible role of calcium channel subunits. Journal of neurophysiology. 99 [PubMed]

Liu XD, Kourennyi DE. (2004). Effects of tetraethylammonium on Kx channels and simulated light response in rod photoreceptors. Annals of biomedical engineering. 32 [PubMed]

Lytton WW. (2006). Neural Query System: Data-mining from within the NEURON simulator. Neuroinformatics. 4 [PubMed]

Mahapatra C, Brain KL, Manchanda R. (2018). A biophysically constrained computational model of the action potential of mouse urinary bladder smooth muscle. PloS one. 13 [PubMed]

McDougal RA, Hines ML, Lytton WW. (2013). Water-tight membranes from neuronal morphology files. Journal of neuroscience methods. 220 [PubMed]

Migliore M, Ferrante M, Ascoli GA. (2005). Signal propagation in oblique dendrites of CA1 pyramidal cells. Journal of neurophysiology. 94 [PubMed]

Morita K. (2008). Possible role of dendritic compartmentalization in the spatial working memory circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Murphy BK, Miller KD. (2003). Multiplicative gain changes are induced by excitation or inhibition alone. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Müllner FE, Wierenga CJ, Bonhoeffer T. (2015). Precision of Inhibition: Dendritic Inhibition by Individual GABAergic Synapses on Hippocampal Pyramidal Cells Is Confined in Space and Time. Neuron. 87 [PubMed]

Narayanan R, Johnston D. (2007). Long-term potentiation in rat hippocampal neurons is accompanied by spatially widespread changes in intrinsic oscillatory dynamics and excitability. Neuron. 56 [PubMed]

Papoutsi A, Kastellakis G, Poirazi P. (2017). Basal tree complexity shapes functional pathways in the prefrontal cortex. Journal of neurophysiology. 118 [PubMed]

Parekh R, Ascoli GA. (2013). Neuronal morphology goes digital: a research hub for cellular and system neuroscience. Neuron. 77 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Pyramidal neuron as two-layer neural network. Neuron. 37 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Online Supplement: About the Model Neuron. 37 Online

Poirazi P, Markaki M, Orphanoudakis S. (2005). Modelling reduced excitability in aged CA1 neurons as a calcium-dependent process Neurocomputing. 65-66

Poleg-Polsky A. (2015). Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-Spikes. PloS one. 10 [PubMed]

Polsky A, Mel B, Schiller J. (2009). Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Polsky A, Mel BW, Schiller J. (2004). Computational subunits in thin dendrites of pyramidal cells. Nature neuroscience. 7 [PubMed]

Rabinowitch I, Segev I. (2006). The interplay between homeostatic synaptic plasticity and functional dendritic compartments. Journal of neurophysiology. 96 [PubMed]

Saudargiene A, Cobb S, Graham BP. (2015). A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus. 25 [PubMed]

Schulz JM, Knoflach F, Hernandez MC, Bischofberger J. (2018). Dendrite-targeting interneurons control synaptic NMDA-receptor activation via nonlinear a5-GABAA receptors. Nature communications. 9 [PubMed]

Scorcioni R, Lazarewicz MT, Ascoli GA. (2004). Quantitative morphometry of hippocampal pyramidal cells: differences between anatomical classes and reconstructing laboratories. The Journal of comparative neurology. 473 [PubMed]

Sidiropoulou K, Poirazi P. (2012). Predictive features of persistent activity emergence in regular spiking and intrinsic bursting model neurons. PLoS computational biology. 8 [PubMed]

Sterratt DC, Groen MR, Meredith RM, van Ooyen A. (2012). Spine calcium transients induced by synaptically-evoked action potentials can predict synapse location and establish synaptic democracy. PLoS computational biology. 8 [PubMed]

. (2004). Does a dendritic democracy need a ruler? Neurocomputing. 58

Tomko M, Benuskova L, Jedlicka P. (2021). A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit. Scientific reports. 11 [PubMed]

Tripp B, Eliasmith C. (2007). Neural populations can induce reliable postsynaptic currents without observable spike rate changes or precise spike timing. Cerebral cortex (New York, N.Y. : 1991). 17 [PubMed]

Tzilivaki A, Kastellakis G, Poirazi P. (2019). Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators Nature communications. 10 [PubMed]

Ujfalussy BB, Makara JK, Lengyel M, Branco T. (2018). Global and Multiplexed Dendritic Computations under In Vivo-like Conditions. Neuron. 100 [PubMed]

Upchurch CM et al. (2022). Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Cells The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 [PubMed]

Urakubo H, Honda M, Froemke RC, Kuroda S. (2008). Requirement of an allosteric kinetics of NMDA receptors for spike timing-dependent plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Wang XD, Hao J, Poo MM , Zhang XH. (2006). How does a neuron perform subtraction? - Arithmetic rules of synaptic integration of excitation and inhibition Advances in Neural Networks-ISNN 2006. 3971

Zeldenrust F, Chameau PJ, Wadman WJ. (2013). Reliability of spike and burst firing in thalamocortical relay cells. Journal of computational neuroscience. 35 [PubMed]

Świetlik D, Białowąs J, Kusiak A, Cichońska D. (2018). A computational simulation of long-term synaptic potentiation inducing protocol processes with model of CA3 hippocampal microcircuit. Folia morphologica. 77 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Pyramidal neuron as two-layer neural network. Neuron. 37 [PubMed]

See more from authors: Poirazi P · Brannon T · Mel BW

References and models cited by this paper

Adelson EH, Bergen JR. (1985). Spatiotemporal energy models for the perception of motion. Journal of the Optical Society of America. A, Optics and image science. 2 [PubMed]

Amitai Y, Friedman A, Connors BW, Gutnick MJ. (1993). Regenerative activity in apical dendrites of pyramidal cells in neocortex. Cerebral cortex (New York, N.Y. : 1991). 3 [PubMed]

Archie KA, Mel BW. (2000). A model for intradendritic computation of binocular disparity. Nature neuroscience. 3 [PubMed]

Cannon RC, Turner DA, Pyapali GK, Wheal HV. (1998). An on-line archive of reconstructed hippocampal neurons. Journal of neuroscience methods. 84 [PubMed]

Cauller LJ, Connors BW. (1992). Functions of very distal dendrites: experimental and computational studies of layer I synapses on neocortical pyramidal cells. Single Neuron Computation.

Chance FS, Abbott LF, Reyes AD. (2002). Gain modulation from background synaptic input. Neuron. 35 [PubMed]

Golding NL, Jung HY, Mickus T, Spruston N. (1999). Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Heeger DJ. (1992). Half-squaring in responses of cat striate cells. Visual neuroscience. 9 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Häusser M, Spruston N, Stuart GJ. (2000). Diversity and dynamics of dendritic signaling. Science (New York, N.Y.). 290 [PubMed]

Kapadia MK, Ito M, Gilbert CD, Westheimer G. (1995). Improvement in visual sensitivity by changes in local context: parallel studies in human observers and in V1 of alert monkeys. Neuron. 15 [PubMed]

Koch C, Poggio T, Torre V. (1982). Retinal ganglion cells: a functional interpretation of dendritic morphology. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 298 [PubMed]

Llinas R, Nicholson C. (1971). Electrophysiological properties of dendrites and somata in alligator Purkinje cells. Journal of neurophysiology. 34 [PubMed]

Magee JC, Cook EP. (2000). Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature neuroscience. 3 [PubMed]

McAdams CJ, Maunsell JH. (1999). Effects of attention on orientation-tuning functions of single neurons in macaque cortical area V4. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Megías M, Emri Z, Freund TF, Gulyás AI. (2001). Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience. 102 [PubMed]

Mel BW. (1992). NMDA-based pattern discrimination in a modeled cortical neuron. Neural Comput. 4

Mel BW. (1992). The clusteron: toward a simple abstraction for a complex neuron Advances in Neural Information Processing Systems 11. 4

Mel BW. (1993). Synaptic integration in an excitable dendritic tree. Journal of neurophysiology. 70 [PubMed]

Mel BW. (1999). Why have dendrites? A computational perspective. Dendrites. Stuart G, Spruston N, and Hausser M eds..

Mel BW, Ruderman DL, Archie KA. (1998). Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Ohzawa I, DeAngelis GC, Freeman RD. (1997). Encoding of binocular disparity by complex cells in the cat's visual cortex. Journal of neurophysiology. 77 [PubMed]

Peterhans E, von der Heydt R. (1989). Mechanisms of contour perception in monkey visual cortex. II. Contours bridging gaps. The Journal of neuroscience : the official journal of the Society for Neuroscience. 9 [PubMed]

Pitts W, Mccullough W. (1943). A logical calculus of the ideas immanent in nervous activity Bull Math Biophys. 5

Poirazi P, Brannon T, Mel BW. (2003). Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron. 37 [PubMed]

Poirazi P, Mel BW. (2001). Impact of active dendrites and structural plasticity on the memory capacity of neural tissue. Neuron. 29 [PubMed]

Rosenblatt F. (1962). Principles Of Neurodynamics.

Rumelhart D, Hinton G, Mcclelland J. (1986). A general framework for parallel distributed processing Parallel Distributed Processing:Explor. in the microstr. of cognit. Rumelhart D and McClelland J eds. 1

Salinas E, Thier P. (2000). Gain modulation: a major computational principle of the central nervous system. Neuron. 27 [PubMed]

Schiller J, Major G, Koester HJ, Schiller Y. (2000). NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature. 404 [PubMed]

Segev I, London M. (2000). Untangling dendrites with quantitative models. Science (New York, N.Y.). 290 [PubMed]

Segev I, Rall W. (1987). Functional possibilities for synapses on dendrites and on dendritic spines. Synaptic Function. Edelman G, Gall W, and Cowan W eds..

Shepherd GM, Brayton RK. (1987). Logic operations are properties of computer-simulated interactions between excitable dendritic spines. Neuroscience. 21 [PubMed]

Spruston N, Hausser M, Stuart G. (1999). Dendrites..

Wei DS et al. (2001). Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons. Science (New York, N.Y.). 293 [PubMed]

Zipser D, Andersen RA. (1988). A back-propagation programmed network that simulates response properties of a subset of posterior parietal neurons. Nature. 331 [PubMed]

References and models that cite this paper

Amatrudo JM et al. (2012). Influence of highly distinctive structural properties on the excitability of pyramidal neurons in monkey visual and prefrontal cortices. The Journal of neuroscience : the official journal of the Society for Neuroscience. 32 [PubMed]

Anwar H et al. (2014). Dendritic diameters affect the spatial variability of intracellular calcium dynamics in computer models. Frontiers in cellular neuroscience. 8 [PubMed]

Arkhipov A et al. (2018). Visual physiology of the layer 4 cortical circuit in silico. PLoS computational biology. 14 [PubMed]

Arsiero M, Lüscher HR, Lundstrom BN, Giugliano M. (2007). The impact of input fluctuations on the frequency-current relationships of layer 5 pyramidal neurons in the rat medial prefrontal cortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 27 [PubMed]

Ashhad S, Narayanan R. (2013). Quantitative interactions between the A-type K+ current and inositol trisphosphate receptors regulate intraneuronal Ca2+ waves and synaptic plasticity. The Journal of physiology. 591 [PubMed]

Azouz R. (2005). Dynamic spatiotemporal synaptic integration in cortical neurons: neuronal gain, revisited. Journal of neurophysiology. 94 [PubMed]

Basak R, Narayanan R. (2018). Active dendrites regulate the spatiotemporal spread of signaling microdomains. PLoS computational biology. 14 [PubMed]

Behabadi BF, Mel BW. (2014). Mechanisms underlying subunit independence in pyramidal neuron dendrites. Proceedings of the National Academy of Sciences of the United States of America. 111 [PubMed]

Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW. (2012). Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites. PLoS computational biology. 8 [PubMed]

Ben-Shalom R et al. (2022). NeuroGPU: Accelerating multi-compartment, biophysically detailed neuron simulations on GPUs Journal of neuroscience methods. 366 [PubMed]

Bianchi D et al. (2012). On the mechanisms underlying the depolarization block in the spiking dynamics of CA1 pyramidal neurons. Journal of computational neuroscience. 33 [PubMed]

Branco T, Clark BA, Häusser M. (2010). Dendritic discrimination of temporal input sequences in cortical neurons. Science (New York, N.Y.). 329 [PubMed]

Branco T, Häusser M. (2011). Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron. 69 [PubMed]

Cazé RD, Jarvis S, Foust AJ, Schultz SR. (2017). Dendrites Enable a Robust Mechanism for Neuronal Stimulus Selectivity. Neural computation. 29 [PubMed]

Combe CL, Canavier CC, Gasparini S. (2018). Intrinsic Mechanisms of Frequency Selectivity in the Proximal Dendrites of CA1 Pyramidal Neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 38 [PubMed]

Cutsuridis V, Cobb S, Graham BP. (2010). Encoding and retrieval in a model of the hippocampal CA1 microcircuit. Hippocampus. 20 [PubMed]

Cutsuridis V, Poirazi P. (2015). A computational study on how theta modulated inhibition can account for the long temporal windows in the entorhinal-hippocampal loop. Neurobiology of learning and memory. 120 [PubMed]

Dan O, Hopp E, Borst A, Segev I. (2018). Non-uniform weighting of local motion inputs underlies dendritic computation in the fly visual system. Scientific reports. 8 [PubMed]

Domijan D. (2004). Recurrent network with large representational capacity. Neural computation. 16 [PubMed]

Doron M, Chindemi G, Muller E, Markram H, Segev I. (2017). Timed Synaptic Inhibition Shapes NMDA Spikes, Influencing Local Dendritic Processing and Global I/O Properties of Cortical Neurons. Cell reports. 21 [PubMed]

Eyal G et al. (2018). Human Cortical Pyramidal Neurons: From Spines to Spikes via Models. Frontiers in cellular neuroscience. 12 [PubMed]

Frank AC et al. (2018). Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory. Nature communications. 9 [PubMed]

Gasparini S, Migliore M, Magee JC. (2004). On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Gleeson P, Steuber V, Silver RA. (2007). neuroConstruct: a tool for modeling networks of neurons in 3D space. Neuron. 54 [PubMed]

Graham BP, Saudargiene A, Cobb S. (2014). Spine head calcium as a measure of summed postsynaptic activity for driving synaptic plasticity. Neural computation. 26 [PubMed]

Gómez González JF, Mel BW, Poirazi P. (2011). Distinguishing Linear vs. Non-Linear Integration in CA1 Radial Oblique Dendrites: It's about Time. Frontiers in computational neuroscience. 5 [PubMed]

Hao J, Wang XD, Dan Y, Poo MM, Zhang XH. (2009). An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Hardie JB, Pearce RA. (2006). Active and passive membrane properties and intrinsic kinetics shape synaptic inhibition in hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Hawkins J, Ahmad S. (2016). Why Neurons Have Thousands of Synapses, a Theory of Sequence Memory in Neocortex. Frontiers in neural circuits. 10 [PubMed]

Hines ML, Markram H, Schürmann F. (2008). Fully implicit parallel simulation of single neurons. Journal of computational neuroscience. 25 [PubMed]

Hiratani N, Fukai T. (2017). Detailed Dendritic Excitatory/Inhibitory Balance through Heterosynaptic Spike-Timing-Dependent Plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 37 [PubMed]

Huys QJ, Ahrens MB, Paninski L. (2006). Efficient estimation of detailed single-neuron models. Journal of neurophysiology. 96 [PubMed]

Huys QJ, Zemel RS, Natarajan R, Dayan P. (2007). Fast population coding. Neural computation. 19 [PubMed]

Häusser M, Mel B. (2003). Dendrites: bug or feature? Current opinion in neurobiology. 13 [PubMed]

Iannella N, Tanaka S. (2006). Synaptic efficacy cluster formation across the dendrite via STDP. Neuroscience letters. 403 [PubMed]

Katona G et al. (2011). Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons. Proceedings of the National Academy of Sciences of the United States of America. 108 [PubMed]

Le Franc Y, Le Masson G. (2010). Multiple firing patterns in deep dorsal horn neurons of the spinal cord: computational analysis of mechanisms and functional implications. Journal of neurophysiology. 104 [PubMed]

Legenstein R, Maass W. (2011). Branch-specific plasticity enables self-organization of nonlinear computation in single neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 31 [PubMed]

Lindsay AE, Lindsay KA, Rosenberg JR. (2005). Increased computational accuracy in multi-compartmental cable models by a novel approach for precise point process localization. Journal of computational neuroscience. 19 [PubMed]

Lytton WW. (2006). Neural Query System: Data-mining from within the NEURON simulator. Neuroinformatics. 4 [PubMed]

Major G, Polsky A, Denk W, Schiller J, Tank DW. (2008). Spatiotemporally graded NMDA spike/plateau potentials in basal dendrites of neocortical pyramidal neurons. Journal of neurophysiology. 99 [PubMed]

Menon V et al. (2013). Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. Neuron. 80 [PubMed]

Migliore M, Ferrante M, Ascoli GA. (2005). Signal propagation in oblique dendrites of CA1 pyramidal cells. Journal of neurophysiology. 94 [PubMed]

Migliore M, Novara G, Tegolo D. (2008). Single neuron binding properties and the magical number 7. Hippocampus. 18 [PubMed]

Migliore M, Tegolo D, Spera E, Unsworth N. (2016). On the cellular mechanisms underlying working memory capacity in humans Neural Network World. 4

Mo CH, Gu M, Koch C. (2004). A learning rule for local synaptic interactions between excitation and shunting inhibition. Neural computation. 16 [PubMed]

Morita K. (2008). Possible role of dendritic compartmentalization in the spatial working memory circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Morita K, Okada M, Aihara K. (2007). Selectivity and stability via dendritic nonlinearity. Neural computation. 19 [PubMed]

Mukunda CL, Narayanan R. (2017). Degeneracy in the regulation of short-term plasticity and synaptic filtering by presynaptic mechanisms. The Journal of physiology. 595 [PubMed]

Murphy BK, Miller KD. (2003). Multiplicative gain changes are induced by excitation or inhibition alone. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Mäki-Marttunen T et al. (2019). Computational modeling of genetic contributions to excitability and neural coding in layer V pyramidal cells: applications to schizophrenia pathology Front. Comput. Neurosci.. 13

Podlaski WF et al. (2017). Mapping the function of neuronal ion channels in model and experiment. eLife. 6 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron. 37 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Online Supplement: About the Model Neuron. 37 Online

Poleg-Polsky A. (2015). Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-Spikes. PloS one. 10 [PubMed]

Poleg-Polsky A. (2019). Dendritic spikes expand the range of well-tolerated population noise structures. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39 [PubMed]

Polsky A, Mel B, Schiller J. (2009). Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Polsky A, Mel BW, Schiller J. (2004). Computational subunits in thin dendrites of pyramidal cells. Nature neuroscience. 7 [PubMed]

Rabinowitch I, Segev I. (2008). Two opposing plasticity mechanisms pulling a single synapse. Trends in neurosciences. 31 [PubMed]

Ros E, Carrillo R, Ortigosa EM, Barbour B, Agís R. (2006). Event-driven simulation scheme for spiking neural networks using lookup tables to characterize neuronal dynamics. Neural computation. 18 [PubMed]

Tomko M, Benuskova L, Jedlicka P. (2021). A new reduced-morphology model for CA1 pyramidal cells and its validation and comparison with other models using HippoUnit. Scientific reports. 11 [PubMed]

Tzilivaki A, Kastellakis G, Poirazi P. (2019). Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators Nature communications. 10 [PubMed]

Ujfalussy BB, Makara JK, Lengyel M, Branco T. (2018). Global and Multiplexed Dendritic Computations under In Vivo-like Conditions. Neuron. 100 [PubMed]

Upchurch CM et al. (2022). Long-Term Inactivation of Sodium Channels as a Mechanism of Adaptation in CA1 Pyramidal Cells The Journal of neuroscience : the official journal of the Society for Neuroscience. 42 [PubMed]

Wang XD, Hao J, Poo MM , Zhang XH. (2006). How does a neuron perform subtraction? - Arithmetic rules of synaptic integration of excitation and inhibition Advances in Neural Networks-ISNN 2006. 3971

Yang GR, Murray JD, Wang XJ. (2016). A dendritic disinhibitory circuit mechanism for pathway-specific gating. Nature communications. 7 [PubMed]

Świetlik D, Białowąs J, Kusiak A, Cichońska D. (2018). A computational simulation of long-term synaptic potentiation inducing protocol processes with model of CA3 hippocampal microcircuit. Folia morphologica. 77 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Online Supplement: About the Model Neuron. 37 Online

See more from authors: Poirazi P · Brannon T · Mel BW

References and models cited by this paper

Amitai Y, Friedman A, Connors BW, Gutnick MJ. (1993). Regenerative activity in apical dendrites of pyramidal cells in neocortex. Cerebral cortex (New York, N.Y. : 1991). 3 [PubMed]

Archie KA, Mel BW. (2000). A model for intradendritic computation of binocular disparity. Nature neuroscience. 3 [PubMed]

Avery RB, Johnston D. (1996). Multiple channel types contribute to the low-voltage-activated calcium current in hippocampal CA3 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Bernander O, Douglas RJ, Martin KA, Koch C. (1991). Synaptic background activity influences spatiotemporal integration in single pyramidal cells. Proceedings of the National Academy of Sciences of the United States of America. 88 [PubMed]

Cash S, Yuste R. (1999). Linear summation of excitatory inputs by CA1 pyramidal neurons. Neuron. 22 [PubMed]

Destexhe A, Mainen ZF, Sejnowski TJ. (1994). Synthesis of models for excitable membranes, synaptic transmission and neuromodulation using a common kinetic formalism. Journal of computational neuroscience. 1 [PubMed]

Golding NL, Jung HY, Mickus T, Spruston N. (1999). Dendritic calcium spike initiation and repolarization are controlled by distinct potassium channel subtypes in CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 19 [PubMed]

Golding NL, Kath WL, Spruston N. (2001). Dichotomy of action-potential backpropagation in CA1 pyramidal neuron dendrites. Journal of neurophysiology. 86 [PubMed]

Hines ML, Carnevale NT. (1997). The NEURON simulation environment. Neural computation. 9 [PubMed]

Hoffman DA, Magee JC, Colbert CM, Johnston D. (1997). K+ channel regulation of signal propagation in dendrites of hippocampal pyramidal neurons. Nature. 387 [PubMed]

Jung HY, Mickus T, Spruston N. (1997). Prolonged sodium channel inactivation contributes to dendritic action potential attenuation in hippocampal pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 17 [PubMed]

Larkum ME, Zhu JJ, Sakmann B. (1999). A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature. 398 [PubMed]

Magee JC. (1998). Dendritic hyperpolarization-activated currents modify the integrative properties of hippocampal CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Magee JC, Johnston D. (1995). Synaptic activation of voltage-gated channels in the dendrites of hippocampal pyramidal neurons. Science (New York, N.Y.). 268 [PubMed]

Mel BW. (1993). Synaptic integration in an excitable dendritic tree. Journal of neurophysiology. 70 [PubMed]

Mel BW, Ruderman DL, Archie KA. (1998). Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Migliore M, Hoffman DA, Magee JC, Johnston D. (1999). Role of an A-type K+ conductance in the back-propagation of action potentials in the dendrites of hippocampal pyramidal neurons. Journal of computational neuroscience. 7 [PubMed]

Moczydlowski E, Latorre R. (1983). Gating kinetics of Ca2+-activated K+ channels from rat muscle incorporated into planar lipid bilayers. Evidence for two voltage-dependent Ca2+ binding reactions. The Journal of general physiology. 82 [PubMed]

Ozawa S, Tsuzuki K, Iino M, Ogura A, Kudo Y. (1989). Three types of voltage-dependent calcium current in cultured rat hippocampal neurons. Brain research. 495 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron. 37 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Pyramidal neuron as two-layer neural network. Neuron. 37 [PubMed]

Sah P, Bekkers JM. (1996). Apical dendritic location of slow afterhyperpolarization current in hippocampal pyramidal neurons: implications for the integration of long-term potentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 16 [PubMed]

Sejnowski TJ, Destexhe A, Mainen ZF. (1998). Kinetic models of synaptic transmission Methods In Neuronal Modeling.

Spruston N, Schiller Y, Stuart G, Sakmann B. (1995). Activity-dependent action potential invasion and calcium influx into hippocampal CA1 dendrites. Science (New York, N.Y.). 268 [PubMed]

Stuart G, Spruston N. (1998). Determinants of voltage attenuation in neocortical pyramidal neuron dendrites. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Stuart G, Spruston N, Sakmann B, Häusser M. (1997). Action potential initiation and backpropagation in neurons of the mammalian CNS. Trends in neurosciences. 20 [PubMed]

References and models that cite this paper

Saudargiene A, Cobb S, Graham BP. (2015). A computational study on plasticity during theta cycles at Schaffer collateral synapses on CA1 pyramidal cells in the hippocampus. Hippocampus. 25 [PubMed]

Polsky A, Mel BW, Schiller J. (2004). Computational subunits in thin dendrites of pyramidal cells. Nature neuroscience. 7 [PubMed]

See more from authors: Polsky A · Mel BW · Schiller J

References and models cited by this paper

Archie KA, Mel BW. (2000). A model for intradendritic computation of binocular disparity. Nature neuroscience. 3 [PubMed]

Ariav G, Polsky A, Schiller J. (2003). Submillisecond precision of the input-output transformation function mediated by fast sodium dendritic spikes in basal dendrites of CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 23 [PubMed]

Beaulieu C, Colonnier M. (1985). A laminar analysis of the number of round-asymmetrical and flat-symmetrical synapses on spines, dendritic trunks, and cell bodies in area 17 of the cat. The Journal of comparative neurology. 231 [PubMed]

Bernander O, Koch C, Douglas RJ. (1994). Amplification and linearization of distal synaptic input to cortical pyramidal cells. Journal of neurophysiology. 72 [PubMed]

Borg-Graham LJ, Grzywacz N. (1992). A model of the direction selectivity circuit in retina: transformations by neurons singly and in concert Single Neuron Computation.

Cash S, Yuste R. (1999). Linear summation of excitatory inputs by CA1 pyramidal neurons. Neuron. 22 [PubMed]

Cauller LJ, Connors BW. (1994). Synaptic physiology of horizontal afferents to layer I in slices of rat SI neocortex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 14 [PubMed]

Cook EP, Johnston D. (1999). Voltage-dependent properties of dendrites that eliminate location-dependent variability of synaptic input. Journal of neurophysiology. 81 [PubMed]

Euler T, Detwiler PB, Denk W. (2002). Directionally selective calcium signals in dendrites of starburst amacrine cells. Nature. 418 [PubMed]

Häusser M, Mel B. (2003). Dendrites: bug or feature? Current opinion in neurobiology. 13 [PubMed]

Häusser M, Spruston N, Stuart GJ. (2000). Diversity and dynamics of dendritic signaling. Science (New York, N.Y.). 290 [PubMed]

Johnston D, Magee JC, Colbert CM, Cristie BR. (1996). Active properties of neuronal dendrites. Annual review of neuroscience. 19 [PubMed]

Kepecs A, Wang XJ, Lisman J. (2002). Bursting neurons signal input slope. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Koch C, Poggio T, Torre V. (1983). Nonlinear interactions in a dendritic tree: localization, timing, and role in information processing. Proceedings of the National Academy of Sciences of the United States of America. 80 [PubMed]

Larkman AU. (1991). Dendritic morphology of pyramidal neurones of the visual cortex of the rat: III. Spine distributions. The Journal of comparative neurology. 306 [PubMed]

Larkum ME, Zhu JJ, Sakmann B. (1999). A new cellular mechanism for coupling inputs arriving at different cortical layers. Nature. 398 [PubMed]

Magee J, Hoffman D, Colbert C, Johnston D. (1998). Electrical and calcium signaling in dendrites of hippocampal pyramidal neurons. Annual review of physiology. 60 [PubMed]

Magee JC. (1999). Dendritic lh normalizes temporal summation in hippocampal CA1 neurons. Nature neuroscience. 2 [PubMed]

Magee JC. (2000). Dendritic integration of excitatory synaptic input. Nature reviews. Neuroscience. 1 [PubMed]

Magee JC, Cook EP. (2000). Somatic EPSP amplitude is independent of synapse location in hippocampal pyramidal neurons. Nature neuroscience. 3 [PubMed]

Margulis M, Tang CM. (1998). Temporal integration can readily switch between sublinear and supralinear summation. Journal of neurophysiology. 79 [PubMed]

McClelland JL, Rumelhart DE. (1985). Distributed memory and the representation of general and specific information. Journal of experimental psychology. General. 114 [PubMed]

Megías M, Emri Z, Freund TF, Gulyás AI. (2001). Total number and distribution of inhibitory and excitatory synapses on hippocampal CA1 pyramidal cells. Neuroscience. 102 [PubMed]

Mel BW. (1992). The clusteron: toward a simple abstraction for a complex neuron Advances in Neural Information Processing Systems 11. 4

Mel BW, Ruderman DL, Archie KA. (1998). Translation-invariant orientation tuning in visual "complex" cells could derive from intradendritic computations. The Journal of neuroscience : the official journal of the Society for Neuroscience. 18 [PubMed]

Migliore M, Shepherd GM. (2002). Emerging rules for the distributions of active dendritic conductances. Nature reviews. Neuroscience. 3 [PubMed]

Nettleton JS, Spain WJ. (2000). Linear to supralinear summation of AMPA-mediated EPSPs in neocortical pyramidal neurons. Journal of neurophysiology. 83 [PubMed]

Oakley JC, Schwindt PC, Crill WE. (2001). Initiation and propagation of regenerative Ca(2+)-dependent potentials in dendrites of layer 5 pyramidal neurons. Journal of neurophysiology. 86 [PubMed]

Oviedo H, Reyes AD. (2002). Boosting of neuronal firing evoked with asynchronous and synchronous inputs to the dendrite. Nature neuroscience. 5 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Arithmetic of subthreshold synaptic summation in a model CA1 pyramidal cell. Neuron. 37 [PubMed]

Poirazi P, Brannon T, Mel BW. (2003). Pyramidal neuron as two-layer neural network. Neuron. 37 [PubMed]

Poirazi P, Mel BW. (2001). Impact of active dendrites and structural plasticity on the memory capacity of neural tissue. Neuron. 29 [PubMed]

Reyes A. (2001). Influence of dendritic conductances on the input-output properties of neurons. Annual review of neuroscience. 24 [PubMed]

Rhodes PA. (1999). Functional implications of active currents in the dendrites of pyramidal neurons Cerebral Cortex. 13

Schiller J, Major G, Koester HJ, Schiller Y. (2000). NMDA spikes in basal dendrites of cortical pyramidal neurons. Nature. 404 [PubMed]

Schiller J, Schiller Y. (2001). NMDA receptor-mediated dendritic spikes and coincident signal amplification. Current opinion in neurobiology. 11 [PubMed]

Schiller J, Schiller Y, Stuart G, Sakmann B. (1997). Calcium action potentials restricted to distal apical dendrites of rat neocortical pyramidal neurons. The Journal of physiology. 505 ( Pt 3) [PubMed]

Segev I, Rall W. (1987). Functional possibilities for synapses on dendrites and on dendritic spines. Synaptic Function. Edelman G, Gall W, and Cowan W eds..

Shepherd GM, Brayton RK. (1987). Logic operations are properties of computer-simulated interactions between excitable dendritic spines. Neuroscience. 21 [PubMed]

Single S, Borst A. (1998). Dendritic integration and its role in computing image velocity. Science (New York, N.Y.). 281 [PubMed]

Tamás G, Szabadics J, Somogyi P. (2002). Cell type- and subcellular position-dependent summation of unitary postsynaptic potentials in neocortical neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 22 [PubMed]

Urban NN, Barrionuevo G. (1998). Active summation of excitatory postsynaptic potentials in hippocampal CA3 pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 95 [PubMed]

Wei DS et al. (2001). Compartmentalized and binary behavior of terminal dendrites in hippocampal pyramidal neurons. Science (New York, N.Y.). 293 [PubMed]

Williams SR, Stuart GJ. (2002). Dependence of EPSP efficacy on synapse location in neocortical pyramidal neurons. Science (New York, N.Y.). 295 [PubMed]

References and models that cite this paper

Almog M, Korngreen A. (2014). A Quantitative Description of Dendritic Conductances and Its Application to Dendritic Excitation in Layer 5 Pyramidal Neurons The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

Azouz R, Gray CM. (2008). Stimulus-selective spiking is driven by the relative timing of synchronous excitation and disinhibition in cat striate neurons in vivo. The European journal of neuroscience. 28 [PubMed]

Behabadi BF, Mel BW. (2014). Mechanisms underlying subunit independence in pyramidal neuron dendrites. Proceedings of the National Academy of Sciences of the United States of America. 111 [PubMed]

Behabadi BF, Polsky A, Jadi M, Schiller J, Mel BW. (2012). Location-dependent excitatory synaptic interactions in pyramidal neuron dendrites. PLoS computational biology. 8 [PubMed]

Branco T, Häusser M. (2011). Synaptic integration gradients in single cortical pyramidal cell dendrites. Neuron. 69 [PubMed]

Cazé RD, Jarvis S, Foust AJ, Schultz SR. (2017). Dendrites Enable a Robust Mechanism for Neuronal Stimulus Selectivity. Neural computation. 29 [PubMed]

Das A, Narayanan R. (2015). Active dendrites mediate stratified gamma-range coincidence detection in hippocampal model neurons. The Journal of physiology. 593 [PubMed]

Deitcher Y et al. (2017). Comprehensive Morpho-Electrotonic Analysis Shows 2 Distinct Classes of L2 and L3 Pyramidal Neurons in Human Temporal Cortex. Cerebral cortex (New York, N.Y. : 1991). 27 [PubMed]

Djurisic M, Popovic M, Carnevale N, Zecevic D. (2008). Functional structure of the mitral cell dendritic tuft in the rat olfactory bulb. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Doiron B, Oswald AM, Maler L. (2007). Interval coding. II. Dendrite-dependent mechanisms. Journal of neurophysiology. 97 [PubMed]

Eyal G et al. (2018). Human Cortical Pyramidal Neurons: From Spines to Spikes via Models. Frontiers in cellular neuroscience. 12 [PubMed]

Fernandez FR, Mehaffey WH, Turner RW. (2005). Dendritic Na+ current inactivation can increase cell excitability by delaying a somatic depolarizing afterpotential. Journal of neurophysiology. 94 [PubMed]

Frank AC et al. (2018). Hotspots of dendritic spine turnover facilitate clustered spine addition and learning and memory. Nature communications. 9 [PubMed]

Gasparini S, Migliore M, Magee JC. (2004). On the initiation and propagation of dendritic spikes in CA1 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 24 [PubMed]

Gidon A, Segev I. (2012). Principles governing the operation of synaptic inhibition in dendrites. Neuron. 75 [PubMed]

Grunditz A, Holbro N, Tian L, Zuo Y, Oertner TG. (2008). Spine neck plasticity controls postsynaptic calcium signals through electrical compartmentalization. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Gómez González JF, Mel BW, Poirazi P. (2011). Distinguishing Linear vs. Non-Linear Integration in CA1 Radial Oblique Dendrites: It's about Time. Frontiers in computational neuroscience. 5 [PubMed]

Górski T et al. (2018). Dendritic sodium spikes endow neurons with inverse firing rate response to correlated synaptic activity. Journal of computational neuroscience. 45 [PubMed]

Hao J, Wang XD, Dan Y, Poo MM, Zhang XH. (2009). An arithmetic rule for spatial summation of excitatory and inhibitory inputs in pyramidal neurons. Proceedings of the National Academy of Sciences of the United States of America. 106 [PubMed]

Hawkins J, Ahmad S. (2016). Why Neurons Have Thousands of Synapses, a Theory of Sequence Memory in Neocortex. Frontiers in neural circuits. 10 [PubMed]

Hay E, Hill S, Schürmann F, Markram H, Segev I. (2011). Models of neocortical layer 5b pyramidal cells capturing a wide range of dendritic and perisomatic active properties. PLoS computational biology. 7 [PubMed]

Hay E, Segev I. (2015). Dendritic Excitability and Gain Control in Recurrent Cortical Microcircuits. Cerebral cortex (New York, N.Y. : 1991). 25 [PubMed]

Hyun JH et al. (2015). Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells. The Journal of physiology. 593 [PubMed]

Iannella N, Tanaka S. (2006). Synaptic efficacy cluster formation across the dendrite via STDP. Neuroscience letters. 403 [PubMed]

Jolivet R, Gerstner W. (2004). Predicting spike times of a detailed conductance-based neuron model driven by stochastic spike arrival. Journal of physiology, Paris. 98 [PubMed]

Jolivet R, Rauch A, Lüscher HR, Gerstner W. (2006). Predicting spike timing of neocortical pyramidal neurons by simple threshold models. Journal of computational neuroscience. 21 [PubMed]

Kampa BM, Stuart GJ. (2006). Calcium spikes in basal dendrites of layer 5 pyramidal neurons during action potential bursts. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Katona G et al. (2011). Roller Coaster Scanning reveals spontaneous triggering of dendritic spikes in CA1 interneurons. Proceedings of the National Academy of Sciences of the United States of America. 108 [PubMed]

Katz Y et al. (2009). Synapse distribution suggests a two-stage model of dendritic integration in CA1 pyramidal neurons. Neuron. 63 [PubMed]

Keren N, Peled N, Korngreen A. (2005). Constraining compartmental models using multiple voltage recordings and genetic algorithms. Journal of neurophysiology. 94 [PubMed]

Larkum ME, Nevian T, Sandler M, Polsky A, Schiller J. (2009). Synaptic integration in tuft dendrites of layer 5 pyramidal neurons: a new unifying principle. Science (New York, N.Y.). 325 [PubMed]

Lavzin M, Rapoport S, Polsky A, Garion L, Schiller J. (2012). Nonlinear dendritic processing determines angular tuning of barrel cortex neurons in vivo. Nature. 490 [PubMed]

Le Franc Y, Le Masson G. (2010). Multiple firing patterns in deep dorsal horn neurons of the spinal cord: computational analysis of mechanisms and functional implications. Journal of neurophysiology. 104 [PubMed]

Li X, Ascoli GA. (2008). Effects of synaptic synchrony on the neuronal input-output relationship. Neural computation. 20 [PubMed]

Lytton WW, Neymotin SA, Wester JC, Contreras D. (2011). Neocortical simulation for epilepsy surgery guidance: Localization and intervention Computational Surgery and Dual Training.

Major G, Polsky A, Denk W, Schiller J, Tank DW. (2008). Spatiotemporally graded NMDA spike/plateau potentials in basal dendrites of neocortical pyramidal neurons. Journal of neurophysiology. 99 [PubMed]

Menon V et al. (2013). Balanced synaptic impact via distance-dependent synapse distribution and complementary expression of AMPARs and NMDARs in hippocampal dendrites. Neuron. 80 [PubMed]

Migliore M, Ferrante M, Ascoli GA. (2005). Signal propagation in oblique dendrites of CA1 pyramidal cells. Journal of neurophysiology. 94 [PubMed]

Miller JA, Kenyon GT. (2007). Extracting number-selective responses from coherent oscillations in a computer model. Neural computation. 19 [PubMed]

Morita K. (2008). Possible role of dendritic compartmentalization in the spatial working memory circuit. The Journal of neuroscience : the official journal of the Society for Neuroscience. 28 [PubMed]

Nevian T, Larkum ME, Polsky A, Schiller J. (2007). Properties of basal dendrites of layer 5 pyramidal neurons: a direct patch-clamp recording study. Nature neuroscience. 10 [PubMed]

Obi-Nagata K et al. (2023). Distorted neurocomputation by a small number of extra-large spines in psychiatric disorders Science Advances. 9(23) [PubMed]

Olshausen BA, Field DJ. (2005). How close are we to understanding v1? Neural computation. 17 [PubMed]

Poleg-Polsky A. (2015). Effects of Neural Morphology and Input Distribution on Synaptic Processing by Global and Focal NMDA-Spikes. PloS one. 10 [PubMed]

Poleg-Polsky A. (2019). Dendritic spikes expand the range of well-tolerated population noise structures. The Journal of neuroscience : the official journal of the Society for Neuroscience. 39 [PubMed]

Poleg-Polsky A, Diamond JS. (2016). NMDA Receptors Multiplicatively Scale Visual Signals and Enhance Directional Motion Discrimination in Retinal Ganglion Cells. Neuron. 89 [PubMed]

Polsky A, Mel B, Schiller J. (2009). Encoding and decoding bursts by NMDA spikes in basal dendrites of layer 5 pyramidal neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 29 [PubMed]

Rabinowitch I, Segev I. (2006). The interplay between homeostatic synaptic plasticity and functional dendritic compartments. Journal of neurophysiology. 96 [PubMed]

Rabinowitch I, Segev I. (2006). The endurance and selectivity of spatial patterns of long-term potentiation/depression in dendrites under homeostatic synaptic plasticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Rabinowitch I, Segev I. (2008). Two opposing plasticity mechanisms pulling a single synapse. Trends in neurosciences. 31 [PubMed]

Rhodes P. (2006). The properties and implications of NMDA spikes in neocortical pyramidal cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 26 [PubMed]

Rindner DJ, Proddutur A, Lur G. (2022). Cell-type specific integration of feedforward and feedback synaptic inputs in the posterior parietal cortex Neuron. 110 [PubMed]

Shu Y, Duque A, Yu Y, Haider B, McCormick DA. (2007). Properties of action-potential initiation in neocortical pyramidal cells: evidence from whole cell axon recordings. Journal of neurophysiology. 97 [PubMed]

Smith SL, Smith IT, Branco T, Häusser M. (2013). Dendritic spikes enhance stimulus selectivity in cortical neurons in vivo. Nature. 503 [PubMed]

Takashima A, Hikosaka R, Takahata M. (2006). Functional significance of passive and active dendritic properties in the synaptic integration by an identified nonspiking interneuron of crayfish. Journal of neurophysiology. 96 [PubMed]

Tamosiunaite M, Porr B, Wörgötter F. (2007). Self-influencing synaptic plasticity: recurrent changes of synaptic weights can lead to specific functional properties. Journal of computational neuroscience. 23 [PubMed]

Timofeeva Y, Lord GJ, Coombes S. (2006). Spatio-temporal filtering properties of a dendritic cable with active spines: a modeling study in the spike-diffuse-spike framework. Journal of computational neuroscience. 21 [PubMed]

Tzilivaki A, Kastellakis G, Poirazi P. (2019). Challenging the point neuron dogma: FS basket cells as 2-stage nonlinear integrators Nature communications. 10 [PubMed]

Ujfalussy BB, Makara JK, Lengyel M, Branco T. (2018). Global and Multiplexed Dendritic Computations under In Vivo-like Conditions. Neuron. 100 [PubMed]

Urban NN, Castro JB. (2005). Tuft calcium spikes in accessory olfactory bulb mitral cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 25 [PubMed]

Wang XD, Hao J, Poo MM , Zhang XH. (2006). How does a neuron perform subtraction? - Arithmetic rules of synaptic integration of excitation and inhibition Advances in Neural Networks-ISNN 2006. 3971

This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.