Effect of riluzole on action potential in cultured human skeletal muscle cells (Wang YJ et al. 2008)

Simulation studies also unraveled that both decreased conductance of I(Na) and increased conductance of I(K(Ca)) utilized to mimic riluzole actions in skeletal muscle cells could combine to decrease the amplitude of action potentials and increase the repolarization of action potentials.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Skeletal muscle cell

Currents: I K,Ca; I Sodium

Model Concept(s): Action Potentials

Simulation Environment: XPPAUT

Implementer(s): Wu, Sheng-Nan [snwu at mail.ncku.edu.tw]; Wang, Ya-Jean

References:

Wang YJ, Lin MW, Lin AA, Wu SN. (2008). Riluzole-induced block of voltage-gated Na+ current and activation of BKCa channels in cultured differentiated human skeletal muscle cells. Life sciences. 82 [PubMed]