A simplified model of NMDA oscillations in lamprey locomotor neurons (Huss et al. 2008)

Using experiments in conjunction with this simplified model, we sought to understand the basic mechanisms behind NMDA-induced oscillations in lamprey locomotor neurons, specifically (a) how the oscillation frequency depends on NMDA concentration and why, and (b) what the minimal number of components for generating NMDA oscillations is (in vitro and in the model).

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Spinal cord lumbar motor neuron alpha ACh cell; Spinal lamprey neuron

Currents: I K; I K,Ca

Receptors: NMDA

Model Concept(s): Simplified Models

Simulation Environment: XPPAUT

References:

Huss M, Wang D, Trané C, Wikström M, Hellgren Kotaleski J. (2008). An experimentally constrained computational model of NMDA oscillations in lamprey CPG neurons. Journal of computational neuroscience. 25 [PubMed]