The model was used to reproduce experimentally determined mean synaptic response characteristics of unitary AMPA and NMDA synaptic stimulations in CA3 pyramidal cells with the objective of inferring the most likely response properties of the corresponding types of synapses. The model is primarily concerned with passive cells, but models of active dendrites are included.
Region(s) or Organism(s): Hippocampus
Cell Type(s): Hippocampus CA3 pyramidal GLU cell
Transmitters: Glutamate
Simulation Environment: NEURON
Implementer(s): Baker, John L [jbakerb at gmu.edu]
References:
Baker JL, Perez-Rosello T, Migliore M, Barrionuevo G, Ascoli GA. (2011). A computer model of unitary responses from associational/commissural and perforant path synapses in hippocampal CA3 pyramidal cells. Journal of computational neuroscience. 31 [PubMed]