Dentate gyrus granule cells highly express the beta4 accessory subunit which confer BK channels with type II properties. The properties of heterologously-expressed BK channels (with and without the beta4 subunit) were used to construct channel models. These were then used to study how they affect single action potentials and trains of spikes in a model dentate gyrus granule cells (based on Aradi and Holmes, 1999).
Model Type: Neuron or other electrically excitable cell
Cell Type(s): Dentate gyrus granule GLU cell
Currents: I K,Ca
Model Concept(s): Action Potentials
Simulation Environment: NEURON
Implementer(s): Jaffe, David B [david.jaffe at utsa.edu]