" ... A computational model, which simulated molecular processes underlying long-term synaptic facilitation (LTF) induction, predicted a rescue protocol of five pulses of 5-HT at non-uniform interstimulus intervals that overcame the consequences of reduced CREB-binding protein (CBP) and restored LTF. ..."
Model Type: Synapse
Region(s) or Organism(s): Aplysia
Cell Type(s): Aplysia sensory neuron
Model Concept(s): Signaling pathways
Simulation Environment: XPPAUT
Implementer(s): Zhang, Yili [Yili.Zhang at uth.tmc.edu]
Liu RY et al. (2013). Deficit in long-term synaptic plasticity is rescued by a computationally predicted stimulus protocol. The Journal of neuroscience : the official journal of the Society for Neuroscience. 33 [PubMed]