Electrodiffusive astrocytic and extracellular ion concentration dynamics model (Halnes et al. 2013)

An electrodiffusive formalism was developed for computing the dynamics of the membrane potential and ion concentrations in the intra- and extracellular space in a one-dimensional geometry (cable). This (general) formalism was implemented in a model of astrocytes exchanging K+, Na+ and Cl- ions with the extracellular space (ECS). A limited region (0< x<l/10 where l is the astrocyte length) of the ECS was exposed to an increase in the local K+ concentration. The model is used to explore how astrocytes contribute in transporting K+ out from high-concentration regions via a mechanism known as spatial buffering, which involves local uptake from high concentration regions, intracellular transport, and release of K+ in regions with lower ECS concentrations.

Model Type: Neuron or other electrically excitable cell; Glia; Extracellular

Cell Type(s): Astrocyte

Currents: I K,leak; Na/K pump; I Cl, leak; I Na, leak

Model Concept(s): Methods; Potassium buffering

Simulation Environment: MATLAB

Implementer(s): Halnes, Geir [geir.halnes at nmbu.no]


Halnes G, Ostby I, Pettersen KH, Omholt SW, Einevoll GT. (2013). Electrodiffusive model for astrocytic and neuronal ion concentration dynamics. PLoS computational biology. 9 [PubMed]

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