A model of local field potentials generated by medial superior olive neurons (Goldwyn et al 2014)

A computational model of local field potentials generated by medial superior olive neurons. These field potentials are known as the "auditory neurophonic". MSO neuron is modeled as a soma and two dendrites (following Mathews et al, Nature Neurosci, 2010). Intracellular and a 1D extracellular domain are dynamically coupled and solved to simulate spatial-temporal patterns of membrane voltage and extracellular voltage in response to trains of synaptic inputs (monolateral or bilateral, excitation and/or inhibition). The model produces spatio-temporal patterns similar to neurophonic responses recorded in vivo, as discussed in the accompanying manuscript.

Model Type: Neuron or other electrically excitable cell

Cell Type(s): Medial Superior Olive (MSO) cell

Currents: I h; I_KLT

Model Concept(s): Evoked LFP

Simulation Environment: MATLAB

Implementer(s): Goldwyn, Joshua [jhgoldwyn at gmail.com]


Goldwyn JH, Mc Laughlin M, Verschooten E, Joris PX, Rinzel J. (2014). A model of the medial superior olive explains spatiotemporal features of local field potentials. The Journal of neuroscience : the official journal of the Society for Neuroscience. 34 [PubMed]

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