Learning intrinsic excitability in Medium Spiny Neurons (Scheler 2014)

"We present an unsupervised, local activation-dependent learning rule for intrinsic plasticity (IP) which affects the composition of ion channel conductances for single neurons in a use-dependent way. We use a single-compartment conductance-based model for medium spiny striatal neurons in order to show the effects of parameterization of individual ion channels on the neuronal membrane potential-curent relationship (activation function). We show that parameter changes within the physiological ranges are sufficient to create an ensemble of neurons with significantly different activation functions. ... "

Model Type: Neuron or other electrically excitable cell

Region(s) or Organism(s): Striatum

Cell Type(s): Neostriatum medium spiny direct pathway GABA cell; Neostriatum medium spiny indirect pathway GABA cell

Currents: I A; I K; I h; I K,Ca; I Calcium; I A, slow; I Cl, leak; I Ca,p

Receptors: GabaA; AMPA; NMDA

Genes: Kv4.2 KCND2; Kv1.1 KCNA1; Kv1.2 KCNA2; Kv4.3 KCND3; Kv1.4 KCNA4; Kv1.3 KCNA3; Kv1.5 KCNA5; Kv3.3 KCNC3; Cav3.2 CACNA1H; Cav3.1 CACNA1G; Cav3.3 CACNA1I; Cav1.3 CACNA1D; Cav1.1 CACNA1S; Cav1.2 CACNA1C; KCa2.1 KCNN1; Kv2.1 KCNB1; Kv3.1 KCNC1; HCN Cnga1; Cav2.1 CACNA1A; Cav2.2 CACNA1B; KCa2.2 KCNN2; Kv1.9 Kv7.1 KCNQ1; IRK; NR2A GRIN2A; NR2B GRIN2B; Kv3.4 KCNC4; Kv4.1 KCND1

Transmitters: Gaba; Glutamate; Ions

Model Concept(s): Intrinsic plasticity

Simulation Environment: MATLAB

Implementer(s): Schumann, Johann [johann.schumann at gmail.com]


Scheler G. (2013). Learning intrinsic excitability in medium spiny neurons F1000Research. 2 [PubMed]

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