CA3 pyramidal neurons: Kv1.2 mediates modulation of cortical inputs (Hyun et al., 2015)

This model simulates the contribution of dendritic Na+ and D-type K+ channels to EPSPs at three different locations of apical dendrites, which mimicking innervation sites of mossy fibers (MF), recurrent fibers (AC), and perforant pathway (PP).

Model Type: Dendrite

Cell Type(s): Hippocampus CA3 pyramidal GLU cell

Currents: I A; I Sodium; I_KD

Genes: Kv1.2 KCNA2

Model Concept(s): Dendritic Action Potentials

Simulation Environment: NEURON

References:

Hyun JH et al. (2015). Kv1.2 mediates heterosynaptic modulation of direct cortical synaptic inputs in CA3 pyramidal cells. The Journal of physiology. 593 [PubMed]