Axonal spheroids and conduction defects in Alzheimer’s disease (Yuan, Zhang, Tong, et al 2022)

PAAS (plaque-associated axonal spheroid(s)) are dystrophic structures that sprout from axons that pass through amyloid beta plaques. If small enough they do not interfere with action potential (AP) propagation. Medium sized ones delay APs, and large, or many spheroids can block single APs and block or delay trains of APs.

Model Type: Neuron or other electrically excitable cell; Axon

Region(s) or Organism(s): Neocortex

Cell Type(s): Hippocampus CA1 pyramidal GLU cell; Neocortex L5/6 pyramidal GLU cell; Neocortex L2/3 pyramidal GLU cell

Model Concept(s): Action Potentials; Pathophysiology; Aging/Alzheimer`s

Simulation Environment: NEURON

Implementer(s): Morse, Tom [Tom.Morse at]; McDougal, Robert [robert.mcdougal at]


Yuan P et al. (2022). PLD3 affects axonal spheroids and network defects in Alzheimer's disease Nature. 612 [PubMed]

There are 6 other versions of this model. You may select a different one below:

View on GitHub
This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.