PAAS (plaque-associated axonal spheroid(s)) are dystrophic structures that sprout from axons that pass through amyloid beta plaques. If small enough they do not interfere with action potential (AP) propagation. Medium sized ones delay APs, and large, or many spheroids can block single APs and block or delay trains of APs.
Region(s) or Organism(s): Neocortex
Simulation Environment: NEURON