Fast AMPA receptor signaling (Geiger et al 1997)


Glutamatergic transmission at a principal neuron-interneuron synapse was investigated by dual whole-cell patch-clamp recording in rat hippocampal slices combined with morphological analysis and modeling. Simulations based on a compartmental model of the interneuron indicated that the rapid postsynaptic conductance change determines the shape and the somatodendritic integration of EPSPs, thus enabling interneurons to detect synchronous principal neuron activity.

Model Type: Synapse

Receptors: AMPA

Transmitters: Glutamate

Model Concept(s): Influence of Dendritic Geometry; Detailed Neuronal Models

Simulation Environment: NEURON

Implementer(s): Roth, Arnd

References:

Geiger JR, L├╝bke J, Roth A, Frotscher M, Jonas P. (1997). Submillisecond AMPA receptor-mediated signaling at a principal neuron-interneuron synapse. Neuron. 18 [PubMed]


This website requires cookies and limited processing of your personal data in order to function. By continuing to browse or otherwise use this site, you are agreeing to this use. See our Privacy policy and how to cite and terms of use.